Changes in Lipid Profile, Body Weight Variables and Cardiovascular Risk in Obese Patients Undergoing One-Anastomosis Gastric Bypass

Abstract

Morbid obesity has a direct impact on the development of cardiovascular disease. One-anastomosis gastric bypass (OAGB) is an effective surgical technique for the control of body weight and the reduction of cardiovascular risk. This work examines the change in weight loss, lipid profile and cardiovascular risk in 100 patients (71 women, 29 men), mean age 42.61 ± 11.33 years at 3, 6, 9, 12, 18 and 24 months after OAGB. At 24 months post-surgery, mean body weight was significantly reduced compared to pre-operative values (116.75 ± 22.19 kg vs. 69.66 ± 13.07 kg), as were mean total cholesterol (201.86 ± 44.60 mg/dL vs. 172.99 ± 32.26 mg/dL), LDL (Low-Density Lipoprotein) cholesterol (126.90 ± 39.81 mg/dL vs. 96.28 ± 26.99 mg/dL), triglycerides (138.05 ± 78.45 mg/dL vs. 76.04 ± 30.34 mg/dL) and cardiovascular risk (total cholesterol/HDL (High-Density Lipoprotein) cholesterol: 4.32 ± 1.24 vs. 2.93 ± 0.71), while the mean HDL cholesterol concentration was significantly higher (49.09 ± 14.16 mg/dL vs. 61.98 ± 14.86 mg/dL) (all p < 0.001). In conclusion, OAGB surgery led to significant reductions in body weight, a significant improvement in the lipid profile, and a reduction in cardiovascular risk.

Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio

“…Previous studies have shown that various interventional weight loss programs among overweight and obese individuals improve patients’ lipid profiles [ 9 , 33 , 36 , 37 ]. A recent retrospective study shows that among a cohort of Japanese patients, non-interventional weight losses of 5% or more are associated with improved LDL-C, TG, and HDL-C levels [ 41 ].…”

“…Overweight and obesity are associated with an increased risk of cardiovascular (CV)-related morbidity such as hypertension (HTN), type 2 diabetes mellitus (DM), ischemic heart disease (IHD), chronic kidney disease (CKD), and dyslipidemia [ 1 , 2 , 3 , 4 , 5 ]. Dyslipidemia is an established risk factor for developing atherosclerosis and subsequent CV events [ 6 , 7 , 8 ], and interventional weight loss among overweight and obese patients improves their lipid profile [ 9 , 10 , 11 , 12 ]. High triglyceride (TG) levels are associated with other lipid abnormalities that predispose an individual to atherosclerosis development, including low levels of high-density lipoprotein cholesterol (HDL-C), high levels of low-density lipoprotein cholesterol (LDL-C), and atherogenic TG-rich lipoprotein remnants [ 13 ].…”

Effect of Bariatric Surgery on Metabolic Syndrome, Framingham Risk Scores and Thyroid Function during One-Year Follow-Up: A Saudi Retrospective Study

“…In agreement with the present results, a significant improvement was found in total cholesterol, LDL-cholesterol, and triglyceride levels (at 3, 6, 9, 12, 18, and 24 months) compared to preoperative. They also reported that HDL-cholesterol increased significantly from 6 months onward, reaching its highest value 24 months postoperative [ 36 ]. The improvement in the lipid profile might be due to the malabsorptive influence of BS [ 37 ].…”

Improvement of Lipid Profile after One-Anastomosis Gastric Bypass Compared to Sleeve Gastrectomy

“…While the efficacy and safety of OAGB have been validated [ 3 , 4 , 5 ] and its ability to control dyslipidemia has now been demonstrated [ 9 , 14 , 24 ], this approach is included in the ongoing debate on which procedure is the most effective in such patients. A moderate amount of studies focused on remission of T2DM, comparing OAGB with other surgical procedures [ 8 , 9 , 11 , 25 , 26 , 27 ].…”