Changes in lipid peroxidation and free radical scavengers in the brain of hyper- and hypothyroid aged rats

Mano, Takamitsu; Sinohara, R; Sawai, Yoshiyuki; Oda, Noriko; Nishida, Yoshio; Mokuno, T; Asano, Katsuaki; Ito, Yoshitake; Kotake, Motoko; Hamada, Minoru; Nakai, Akira; Nagasaka, Akio

doi:10.1677/joe.0.1470361

Cited by 44 publications

(23 citation statements)

References 12 publications

(15 reference statements)

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“…Moreover, an adequate iodine supply for the organism is necessary for optimal thyroid function which is also a requirement for a well-functioning antioxidant defence system. 8,9 The question arises, of whether the eective iodide concentration in our model system can be achieved in vivo through the application of an iodine brine as used in the Austrian spa Bad Hall. The total iodine concentration of the local iodine brine is in the range of about 300 mM.…”

Section: Resultsmentioning

confidence: 99%

Effect of iodide on total antioxidant status of human serum

Winkler¹,

Griebenow²,

Wonisch

2000

Cell Biochemistry & Function

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Free radicals and subsequent lipid peroxidation have been implicated in the pathogenesis of several degenerative and chronic diseases which are also treated frequently in spas. There are some data arising from previous studies which support an antioxidant or scavenging effect of iodide, being the essential ingredient of a therapeutically used local brine. The aim of the study was to test the antioxidant capacity of iodide in human serum. For this reason we measured the so-called Total Antioxidant Status determined by a colorimetric method, which reflects the protection against the attack of reactive oxygen species, including enzymic and non-enzymic antioxidants. Exogenous iodide applied as NaI, shows a significantly increased antioxidant capacity in comparison with NaCl at a concentration of 15 microM, which is quite comparable to the upper range of serum iodide levels achieved through balneo-therapeutical intervention. This result is in accordance with previous results from in vitro depolymerization experiments with hyaluronic acid. The antioxidant effect of 15 microM NaI has been found to be approaching the physiologically relevant concentration of ascorbic acid (50 microM).

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Section: Resultsmentioning

confidence: 99%

Effect of iodide on total antioxidant status of human serum

Winkler¹,

Griebenow²,

Wonisch

2000

Cell Biochemistry & Function

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“…Therefore, the increase we obtained in oxidant and antioxidant system activities due to hyperthyroidism is consistent with the findings of other researchers. Mano et al 31 investigated lipid peroxidation and free radical elimination mechanisms in cerebral tissues of rats with hyperthyroidism and hypothyroidism. It was reported in their study that the elimination systems compensated for the free radicals formed.…”

Section: Discussionmentioning

confidence: 99%

Pinealectomy increases oxidant damage in kidney and testis caused by hyperthyroidism in rats

Moğulkoç

Baltacı

Aydın

et al. 2006

Cell Biochem. Funct.

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Thyroid hormones regulate energy metabolism and act on mitochondria which are an important source of free radicals in the cell. The pineal gland activates antioxidant systems via melatonin secretion and thus has a protective function in body tissues. The present study was conducted to determine the oxidative damage caused by hyperthyroidism in kidney and testis tissues of pinealectomized rats. Experimental animals were allocated to three groups: 1, control group; 2, sham pinealectomy-hyperthyroidic group; and 3, pinealectomy-hyperthyroidic group. Hyperthyroidism was induced by A 3-week intraperitoneal administration of thyroxin after sham pinealectomy or pinealectomy. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in kidney and testis tissues. MDA levels of the kidney and testis tissue in the pinealectomy and hyperthyroidic groups were significantly higher than those in the sham pinealectomy-hyperthyroidic group and the control group (p < 0.001). GSH levels of both kidney and testis tissues were significantly higher in the sham-pinealectomy-hyperthyroidic group when compared to the other two groups (p < 0.001). This increase in GSH levels was more evident in the pinealectomy-hyperthyroidic group than in the control group (p < 0.001). The results of our study demonstrate that MDA and GSH levels in kidney and testis tissues increased due to hyperthyroidism and that pinealectomy made the increase in MDA levels more apparent, while decreasing GSH levels.

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“…This is in line with the results of Venditti et al [110] who showed that in all tissues of hypothyroid rats, the malondialdehyde (MDA) levels did not differ significantly from euthyroid values. Mano et al [15] found that the concentration of lipid peroxides, determined indirectly by the measurement of thiobarbituric acid reactants, did not change in hypothyroid rats when compared with the euthyroid animals. Dariyerli et al [227] showed that there is no statistically significant difference found between hypothyroid and control groups in the lipid peroxidation indicator MDA.…”

Section: Antioxidant Statusmentioning

confidence: 99%

“…The changes in the levels of the scavengers -tocopherol, glutathione [15] and coenzyme Q [16] and activities of antioxidant enzymes [11]were found to be imbalanced and often opposite.…”

Section: Introductionmentioning

confidence: 98%