Effect of iodide on total antioxidant status of human serum

Abstract

Free radicals and subsequent lipid peroxidation have been implicated in the pathogenesis of several degenerative and chronic diseases which are also treated frequently in spas. There are some data arising from previous studies which support an antioxidant or scavenging effect of iodide, being the essential ingredient of a therapeutically used local brine. The aim of the study was to test the antioxidant capacity of iodide in human serum. For this reason we measured the so-called Total Antioxidant Status determined by a colorimetric method, which reflects the protection against the attack of reactive oxygen species, including enzymic and non-enzymic antioxidants. Exogenous iodide applied as NaI, shows a significantly increased antioxidant capacity in comparison with NaCl at a concentration of 15 microM, which is quite comparable to the upper range of serum iodide levels achieved through balneo-therapeutical intervention. This result is in accordance with previous results from in vitro depolymerization experiments with hyaluronic acid. The antioxidant effect of 15 microM NaI has been found to be approaching the physiologically relevant concentration of ascorbic acid (50 microM).

Antiproliferative/cytotoxic effects of molecular iodine, povidone-iodine and Lugol's solution in different human carcinoma cell lines

“…This is in line with the observation that I 2 treatment of patients with benign breast disease led to a bilateral reduction in breast size and a remission of disease symptoms, which was not observed when iodide was administered (17). Other authors have proposed that iodine, if ingested as I 2 at concentrations higher than 3 mg per day, acts as an antioxidant and prevents lipoperoxidation in various organs, including the brain (18). In a recent study, Delgado et al (19) supplemented Sprague-Dawley rats with I 2 and KJ in drinking water.…”

Nachhaltigkeit der Erhöhung des wasserlöslichen antioxidativen Schutzmechanismus (ACW) in der nicht stimuliert gewonnenen Tränenflüssigkeit nach lodid-lontophoresebehandlungen in Bad Hall

“…In fruheren Studien wurde gezeigt, dass der antioxidative Status durch die Zufuhr von Iodid im Rahmen einer Bad Haller Kur positiv beeinflusst werden kann [7,15], da Iodid als Antioxidans and Sauerstoffradikalfdnger wirkt [11] and das antioxidative Potential im Serum and der Tranenflussigkeit erhohen kann [12].…”

A case–control study on seaweed consumption and the risk of breast cancer

“…Animal studies (10,22,23) and in vitro studies (23 -25) demonstrated the anticarcinogenic effects of seaweeds against mammary carcinogenesis. Iodine as well as other components of seaweeds have been suggested to act as antioxidants (26) and induce apoptosis in human breast cancer cell lines (23) . In an ecological study, the regions where iodine intake was low had higher breast cancer mortality rates (27) .…”