Changes in leptin, serotonin, and cortisol after eight weeks of aerobic exercise with probiotic intake in a cuprizone-induced demyelination mouse model of multiple sclerosis

Sajedi, Donya; Shabani, Ramin; Elmieh, Alireza

doi:10.1016/j.cyto.2021.155590

Cited by 15 publications

(11 citation statements)

References 77 publications

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“…To minimize potential confounding factors, such as differences in stress, sound and light exposure, the sedentary control mice were left on the treadmill without running for the same duration as the exercise groups. No animal was excluded from the experiments 36 (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

Effects of exercise training with Lactobacillus plantarum intake on ionized calcium‐binding adaptor molecule 1, glial fibrillary acidic protein, interleukin‐6 and interleukin‐1β in cuprizone‐induced demyelination mouse model of multiple sclerosis

Sajedi

Shabani

Elmieh

2021

Clinical & Exp Neuroim

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Objective: Multiple sclerosis (MS) is a central nervous system disorder characterized by inflammation, demyelination and neurodegeneration. It has been suggested that exercise and intake of probiotics might influence MS pathology and, thereby, slow down the disease process in MS patients. Therefore, this study aimed to investigate the effect of exercise training with Lactobacillus plantarum intake on ionized calciumbinding adaptor molecule 1, glial fibrillary acidic protein, interleukin (IL)-6 and IL-1β in cuprizone-induced demyelination mouse model of MS. Methods: Mice were exposed to cuprizone for 13 weeks. In the fifth week, motor and balance tests were carried out on them. The mice (n = 5 per group) were randomly divided into five groups: control (C), MS, MS with exercise (MS + Exe), MS with probiotics (MS + Pro) and MS with probiotics and exercise (MS + Pro + Exe). The exercise groups carried out aerobic exercises 5 days a week for 2 months. The mice received probiotic by gavage. One day after the interventions finished, the mice were killed. Biochemical and molecular biology analyses were carried out. Results: Ionized calcium-binding adaptor molecule 1 and glial fibrillary acidic protein expression values in the MS + Pro + Exe, MS + Pro, and MS + Exe groups showed a significant decrease compared with the MS group (P < .05). Also, glial fibrillary acidic protein gene expression in the intervention groups showed an insignificant decrease (P > .05). The IL-6 and IL-1β values in the MS + Exe and MS + Pro + Exe groups showed a significant decrease compared with the MS group (P < .05). Conclusions: Exercise with the intake of probiotics improved demyelination in the cuprizone-induced demyelination mouse model of MS.

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Section: Methodsmentioning

confidence: 99%

Effects of exercise training with Lactobacillus plantarum intake on ionized calcium‐binding adaptor molecule 1, glial fibrillary acidic protein, interleukin‐6 and interleukin‐1β in cuprizone‐induced demyelination mouse model of multiple sclerosis

Sajedi

Shabani

Elmieh

2021

Clinical & Exp Neuroim

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“…Some observations concluded that cortisol levels were high and low among PwMS, in which depression and anxiety have been reported with high levels of cortisol in these patients [ 15 , 17 , 18 ]. The HPA axis is affected by exercise intensity, duration, and rest breaks, with changes in adrenocorticotropic hormone (ACTH) and cortisol levels [ 19 ]. Furthermore, for HPA axis stimulation, the exercise intensity threshold must be 50–60% of maximal oxygen absorption (VO2 max) [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…The HPA axis is affected by exercise intensity, duration, and rest breaks, with changes in adrenocorticotropic hormone (ACTH) and cortisol levels [ 19 ]. Furthermore, for HPA axis stimulation, the exercise intensity threshold must be 50–60% of maximal oxygen absorption (VO2 max) [ 19 ]. The highest cortisol reaction has been reported in high-volume and high-intensity interventions, which reduce muscular inflammation, cytokine production, and muscle injury by elevating glucocorticoid sensitivity [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Tele-Pilates and Tele-Yoga on Biochemicals, Physical, and Psychological Parameters of Females with Multiple Sclerosis

Najafi

Hadizadeh

Cheong

et al. 2023

JCM

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Background: People with multiple sclerosis (PwMS) suffer from some comorbidities, including physical and psychiatric disorders, low quality of life (QoL), hormonal dysregulation, and hypothalamic-pituitary-adrenal axis dysfunction. The current study aimed to investigate the effects of eight weeks of tele-yoga and tele-Pilates on the serum levels of prolactin and cortisol and selected physical and psychological factors. Methods: Forty-five females with relapsing remitting multiple sclerosis, based on age (18–65), expanded disability status scale (0–5.5), and body mass index (20–32), were randomly assigned to tele-Pilates, tele-yoga, or control groups (n = 15). Serum blood samples and validated questionnaires were collected before and after interventions. Results: Following online interventions, there was a significant increase in the serum levels of prolactin (p = 0.004) and a significant decrease in cortisol (p = 0.04) in the time × group interaction factors. In addition, significant improvements were observed in depression (p = 0.001), physical activity levels (p < 0.001), QoL (p ≤ 0.001), and the speed of walking (p < 0.001). Conclusion: Our findings suggest that tele-yoga and tele-Pilates training could be introduced as patient-friendly, non-pharmacological, add-on therapeutic methods for increasing prolactin and decreasing cortisol serum levels and achieving clinically relevant improvements in depression, walking speed, physical activity level, and QoL in female MS patients.

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“…lucocorticoids (GC) are endogenous hormones produced by the body. The adrenal fasciculate zone of the adrenal cortex is where steroid hormones are produced and secreted (1). Cortisol levels higher than circulating levels signal the anterior pituitary to decrease the adrenocorticotropic hormone (ACTH) production.…”

Section: Introductionmentioning

confidence: 99%

“…The hypothalamus can be signaled to secrete less corticotropin-releasing hormone (CRH) when it is exposed to higher cortisol or ACTH concentration. The hypothalamic-pituitaryadrenocortical (HPA) axis is responsible for this interconnected feedback loop (1,2). Studies have revealed that exercise has shown to affect the feedback from the HPA-axis towards the phycological stress factors.…”

Section: Introductionmentioning

confidence: 99%

Exercise habits and cortisol level among women at a local Zumba club

Kareri¹,

Manafe²,

Sasputra³

2022

Biomedicine

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Introduction and Aim: Cortisol has a vital role in helping the body deal with stress. It is known as the primary stress hormone. Cortisol modulates many changes in the body in response to stress, including blood glucose metabolism, fat, protein, carbohydrate metabolism into energy (gluconeogenesis), immune and anti-inflammatory response. The aim of this study was to determine the impact of Zumba exercise on cortisol levels in Zumba club participants in Indonesia. Materials and Methods: The design of the research is observational using a cross-sectional analytic study method. The samples in this study were 25 women of productive age in the I'M Z crew Zumba club in Indonesia with a purposive amplification technique. Results: The results showed that the subjects who routinely did Zumba exercise (? 3x a week) or who did not excercie routinely (1-2x a week) to have cortisol levels within normal limits (3.09-16.66 ug/dL). The results of this study also showed that subjects who routinely did Zumba exercise (? 3x a week) have higher cortisol mean (7.82 ± 3.50) than subjects who did not regularly exercise (1-2x a week; 6.47 ± 3.46). Conclusion: There was no significant relationship between exercise habits and cortisol levels in the research subjects.

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Changes in leptin, serotonin, and cortisol after eight weeks of aerobic exercise with probiotic intake in a cuprizone-induced demyelination mouse model of multiple sclerosis

Cited by 15 publications

References 77 publications

Effects of exercise training with Lactobacillus plantarum intake on ionized calcium‐binding adaptor molecule 1, glial fibrillary acidic protein, interleukin‐6 and interleukin‐1β in cuprizone‐induced demyelination mouse model of multiple sclerosis

Effects of exercise training with Lactobacillus plantarum intake on ionized calcium‐binding adaptor molecule 1, glial fibrillary acidic protein, interleukin‐6 and interleukin‐1β in cuprizone‐induced demyelination mouse model of multiple sclerosis

Effects of Tele-Pilates and Tele-Yoga on Biochemicals, Physical, and Psychological Parameters of Females with Multiple Sclerosis

Exercise habits and cortisol level among women at a local Zumba club

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