Frailty is an age-related state characterized by a reduced physiological reserve, and is associated with adverse health outcomes in the elderly. We analyzed the data from 895 adults aged 60 years and above, and investigated the relationships between midlife and late-life social activities, intellectual activities, working hours, and dietary habits and frailty status. Participation in social or intellectual activities in late life was less prevalent among those who were frail than among those who were robust. A greater proportion of those who were frail had worked long hours in midlife. After adjustment for confounders, participating in social activities or intellectual activities in late life was associated with a reduced risk for prefrailty and frailty, while working long hours in midlife was associated with a higher risk for frailty. The risk of frailty decreased with increasing healthy diet scores in midlife and late life. When the results were stratified by gender, late-life participation in social activities and midlife or late-life participation in intellectual activities correlated negatively with prefrailty/frailty only in women. Our study suggests that social and intellectual activities are inversely associated with frailty status, but the association seems to differ based on gender. www.aging-us.com 289 AGING reduced, making individuals more vulnerable to stressors and adverse health outcomes such as falls, comorbidities, disabilities and mortality [2, 3]. Frailty is a dynamic process that can worsen or be reversed over time [4-8]. The identification of modifiable risk factors and protective factors for frailty is essential for healthcare planning and targeted intervention development. However, the factors associated with frailty are not well understood. Numerous studies have indicated that active participation in leisure activities [9, 10], social activities [11-16] or intellectual activities [17-20] can improve the cognitive reserve [9-11, 15, 17, 18], enhance mental health [13, 16], reduce functional disabilities [14, 20] and delay mortality [11, 12, 19]. On the other hand, working long hours (i.e., more than 40 hours per week or eight hours per day) appears to be associated with deleterious effects such as depression, anxiety, sleep disorders and coronary heart disease [21]. Despite the evidence that engagement in various lifestyle activities influences health outcomes, few studies have examined frailty as an outcome variable. Additionally, although the diet is a frequently studied lifestyle factor, its impact on frailty has not received much attention [22, 23]. Understanding the associations of health-related lifestyle factors with frailty could help healthcare providers formulate screening and delivery strategies for health and social care. In this study, we evaluated the associations of frailty status with midlife and latelife social activities, intellectual activities, working hours and dietary consumption patterns in a community-based sample of older adults in Singapore. RESULTS The final sampl...