Changes in left atrial dimension and function and left ventricular geometry in newly diagnosed untreated hypertensive subjects

Adebayo, Adedeji K; Oladapo, Olulola O; Adebiyi, Adewole A; Ogunleye, Olayinka O; Ogah, Okechukwu S; Ojji, Dike; Aje, Akinyemi; Adeoye, Moshood A; Ochulor, Kenneth C; Enakpene, Evbu; Falase, A. O.

doi:10.2459/jcm.0b013e3282f2197f

Cited by 15 publications

(8 citation statements)

References 42 publications

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“…Changes in the left ventricle (LV) under the effects of hypertension are well studied including LV hypertrophy, abnormal geometry, and diastolic dysfunction [1]. The left atrium (LA) is also affected by hypertension and LA enlargement is noted even earlier in mild hypertension [2].…”

Section: Introductionmentioning

confidence: 99%

Changes of Left Atrial Phasic Function Assessed by Speckle Tracking Echocardiography in Untreated Hypertension

Tsai

Huang

Liu

et al. 2012

Journal of Medical Ultrasound

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KEY WORDShypertension, left atrium, speckle tracking echocardiography, strain, strain rate Changes in the three phases of left atrial (LA) function have not been well studied in hypertension. We studied phasic function of LA by speckle tracking echocardiography (STE) in hypertension. Sixty-one consecutive untreated hypertension patients and 32 sex-and age-matched healthy participants were included. Two-dimensional (2D) images obtained from apical four-chamber and two-chamber views were used for STE analysis of LA. LA peak positive strain (39.8 AE 10.9 vs. 45.3 AE 12.7 %, p Z 0.031), peak negative strain (À2.2 AE 1.5 vs. À3.0 AE 1.9 %, p Z 0.029), and conduit strain rate (À2.0 AE 0.5 vs. À2.4 AE 0.6 1/s, p Z 0.005) were significantly decreased in hypertension. Twenty hypertensive patients (32%) had diastolic dysfunction. Positive strain (34.8 AE 7.2 vs. 42.2 AE 11.6 %, p Z 0.012) and conduit strain rate (À1.7 AE 0.4 vs. À2.2 AE 0.5 1/ s, p < 0.001) were decreased in patients with diastolic dysfunction. Only conduit strain rate was independently associated with diastolic dysfunction (OR 11.9, p Z 0.026) after multivariable analysis. LA phasic function is decreased in untreated hypertension. Decreased LA conduit function is associated with diastolic dysfunction in hypertension. ª

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Section: Introductionmentioning

confidence: 99%

Changes of Left Atrial Phasic Function Assessed by Speckle Tracking Echocardiography in Untreated Hypertension

Tsai

Huang

Liu

et al. 2012

Journal of Medical Ultrasound

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“…In another study, the authors evaluated left atrial structural and functional alterations in hypertension which was found to be statistically different compared to age and sex-matched apparently normal individuals [140] .…”

Section: Left Ventricular Diastolic Dysfunctionmentioning

confidence: 99%

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Ogah¹,

Okpechi²,

Chukwuonye³

et al. 2012

WJC

Self Cite

219

232

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To review studies on hypertension in Nigeria over the past five decades in terms of prevalence, awareness and treatment and complications. Following our search on Pubmed, African Journals Online and the World Health Organization Global cardiovascular infobase, 1060 related references were identified out of which 43 were found to be relevant for this review. The overall prevalence of hypertension in Nigeria ranges from 8%-46.4% depending on the study target population, type of measurement and cut-off value used for defining hypertension. The prevalence is similar in men and women (7.9%-50.2% vs 3.5%-68.8%, respectively) and in the urban (8.1%-42.0%) and rural setting (13.5%-46.4%). The pooled prevalence increased from 8.6% from the only study during the period from 1970-1979 to 22.5% (2000-2011). Awareness, treatment and control of hypertension were generally low with attendant high burden of hypertension related complications. In order to improve outcomes of cardiovascular disease in Africans, public health education to improve awareness of hypertension is required. Further epidemiological studies on hypertension are required to adequately understand and characterize the impact of hypertension in society.

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“…Compared to their age-and sex-matched controls, hypertensive Africans show statistically significant left atrial structural and functional alterations [21].…”

Section: Atrial Function and Dysfunctionmentioning

confidence: 97%

“…Absolute and indexed left atrial diameter, area, or volume is increased in African hypertensive subjects [20,21]. Compared to their age-and sex-matched controls, hypertensive Africans show statistically significant left atrial structural and functional alterations [21].…”

Section: Atrial Function and Dysfunctionmentioning

confidence: 99%

Cardiomyopathies in Sub-Saharan Africa: Hypertensive Heart Disease (Cardiomyopathy), Peripartum Cardiomyopathy and HIV-Associated Cardiomyopathy

Falase¹

2017

Cardiomyopathies - Types and Treatments

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Cardiomyopathy is an important cause of cardiac-related morbidity and mortality in sub-Saharan Africa. Dilated cardiomyopathy is responsible for 20-30% of adult heart failure (HF) in the region. It is only second to hypertensive heart disease as etiological risk factor for HF in many parts of the continent. The aim of the chapter is to review the current epidemiology, clinical features, management, and prognosis of hypertensive heart disease, peripartum cardiomyopathy, and HIV-associated cardiomyopathy in subSaharan Africa.

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Changes in left atrial dimension and function and left ventricular geometry in newly diagnosed untreated hypertensive subjects

Abstract: Changes in the geometry of the left ventricle occur early in hypertension and precede deterioration in left ventricular systolic function. The corresponding left atrial changes are marginal and are indicative of increased left atrial length and accentuated atrial systolic function.

Cited by 15 publications

References 42 publications

Changes of Left Atrial Phasic Function Assessed by Speckle Tracking Echocardiography in Untreated Hypertension

Changes of Left Atrial Phasic Function Assessed by Speckle Tracking Echocardiography in Untreated Hypertension

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Cardiomyopathies in Sub-Saharan Africa: Hypertensive Heart Disease (Cardiomyopathy), Peripartum Cardiomyopathy and HIV-Associated Cardiomyopathy

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