Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies

Belo, Luı́s; Caslake, Muriel; Gaffney, Dairena; Santos-Silva, Alice; Pereira-Leite, L.; Quintanilha, Alexandre; Rebelo, Irene

doi:10.1016/s0021-9150(01)00734-1

Cited by 162 publications

(151 citation statements)

References 23 publications

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“…Twenty‐seven studies reported on HDL levels,32, 37, 41, 44, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 of which 24 studies could be included in a meta‐analysis 32, 37, 41, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72. HDL level was lower in pre‐eclampsia than in controls (mean difference −6.29 mmol/L; 95%CI −9.74−2.85; P = 0.0003) with the strongest effect in subgroup analysis for severe pre‐eclampsia vs. controls ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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“…It also stated that early pregnancy dyslipidemia is associated with increased risk of preeclampsia. Belo et al in their study concluded that preeclamptic women exhibited, in third trimester, higher mean serum triglyceride concentration and lower high density lipoprotein cholesterol [4]. They emphasized that this 'atherogenic' lipid profile in preeclamptic females may be a potential contributor to endothelial cell dysfunction.…”

Section: Discussion and Analysismentioning

confidence: 96%

Estimation of Lipid Profile in Subjects of Preeclampsia

Gohil

Patel

Gupta

2011

J Obstet Gynecol India

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“…As mentioned above, much like with the metabolic syndrome outside of pregnancy (47), endothelial dysfunction and systemic inflammation are associated with this complex in pregnancy (48). Further, hypertriglyceridemia and low HDL-C have been associated with both gestational diabetes (49) and pre-eclampsia (50). Thus, the increased risk of pre-eclampsia in women with gestational diabetes may be reflecting an underlying common pathophysiology related to the metabolic syndrome outside of pregnancy.…”

Section: Discussionmentioning

confidence: 96%

Gestational diabetes and pre-eclampsia: common antecedents?

Wendland

Duncan

Belizán

et al. 2008

Arq Bras Endocrinol Metab

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Objetivo: Avaliar a concordância do padrão de fatores de risco de mulheres que desenvolvem diabetes gestacional e pré-eclâmpsia. Métodos: Estudo de coorte prospectivo em clínicas de atendimento pré-natal do Sistema Único de Saúde de seis capitais do Brasil, 4.766 mulheres grávidas de 20 a 48 anos de idade foram arroladas de maneira consecutiva entre a 20º e 28º semanas de gestação. O hábito de fumar e os fatores de risco tradicionais para pré-eclâmp-sia e diabetes gestacional foram obtidos por entrevista no arrolamento. diabetes gestacional foi diagnosticada usando um teste oral de tolerância a glicose com 75 g e pré-eclâmpsia por meio de revisão de prontuário. Resultados: diabetes gestacional e pré-eclâmpsia são associadas com idade (rc 2,07; 95% Ic 1,65-2,23 e rc 1,55; 95% Ic 1,08-2,23, respectivamente), índice de massa corporal pré-gestacional (rc 1,62; 95% Ic 1,40-3,53 e rc 1,83; 95% Ic 1,52-4,80, respectivamente) e ganho de peso precocemente durante a gestação (rc 1,28; 95% Ic 1,12-1,47 e rc 1,27; 95% Ic 1,06-1,52, respectivamente).

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Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies

Cited by 162 publications

References 23 publications

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Estimation of Lipid Profile in Subjects of Preeclampsia

Gestational diabetes and pre-eclampsia: common antecedents?

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