Changes in laboratory values and their relationship with time after rupture of an abdominal aortic aneurysm

Abstract

Both survivors and nonsurvivors of RAAA surgery displayed characteristic time-dependent laboratory abnormalities. Awareness of these responses may help us predict patients prone to complications.

Early elevated serum gamma glutamyl transpeptidase after liver transplantation is associated with better survival

“…Recently, several epidemiological studies have shown that a higher serum GGT level, even within the normal range, is associated with cardiovascular risk factors such as hypertension, hypertriglyceridemia, obesity, type 2 diabetes mellitus and stroke, as well as certain types of cancer 2– 10 . In contrast to these studies, we observed that after surgery for ruptured abdominal aortic aneurysm 11 or after liver resection 12 , GGT is transiently increased in patients who had a good outcome. In these short-term observational studies GGT level was inversely related to other liver laboratory parameters such as aspartate aminotransferase (ALT), alanine aminotransferase (AST) as well as total bilirubin (TBI) 11, 12 .…”

“…In contrast to these studies, we observed that after surgery for ruptured abdominal aortic aneurysm 11 or after liver resection 12 , GGT is transiently increased in patients who had a good outcome. In these short-term observational studies GGT level was inversely related to other liver laboratory parameters such as aspartate aminotransferase (ALT), alanine aminotransferase (AST) as well as total bilirubin (TBI) 11, 12 . We observe that in the early postoperative period after a liver transplantation (LT) a transient gradual increase in GGT also occurs.…”

“…Although the liver might regenerate to some extent after LT, there is no conclusive evidence to support this hypothesis. As we mentioned earlier, we observed a transient increase in serum GGT levels in patients who survived a surgical repair for a ruptured abdominal aortic aneurysm 11 . In the latter group, it is less likely that significant liver regeneration occurs.…”

“…Previously, we have reported improved outcome in patients with significantly increased levels of GGT in the early post-operative period following liver resection 12 and surgical repair of a ruptured abdominal aortic aneurysm 11 . However, those studies were not designed to address changes in GGT progression over time.…”

Systematic comparison of routine laboratory measurements with in-hospital mortality: ICU-Labome, a large cohort study of critically ill patients

“…Likewise, in patients with liver disease, elevated GGT is considered a marker of cholestasis together with indicators such as bilirubin and alkaline phosphatase. We observed earlier that secondarily elevated GGT was associated with increased survival rates after liver transplantation, liver resection and after surgical repair of a ruptured abdominal aortic aneurysm [28][29][30]. The current observation in a large cohort of critically ill patients as well as in patients with prolonged ICU stay (SMF §12.1) or in subgroups without known primary liver disease (e.g.…”