Changes in intermediate metabolism and oxidative balance parameters in sexually matured three-barbeled catfishes exposed to herbicides from rice crops (Roundup ® , Primoleo ® and Facet ® )

Persch, Tanilene Sotero Pinto; Silva, Patrícia Rodrigues da; Santos, Sarah Helen Dias dos; Freitas, Betânia Souza de; Oliveira, Guendalina Turcato

doi:10.1016/j.etap.2018.01.004

Cited by 17 publications

(8 citation statements)

References 49 publications

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“…Formulated glyphosate preparations (Roundup R , Roundup Transorb R ) exerted even stronger toxicity to this and related guppy species (De Souza Filho et al, 2013;Harayashiki et al, 2013;Rocha et al, 2015;dos Santos et al, 2017) with exposure-time dependent hepatic histopathological damage (dos Santos et al, 2017) or genotoxicity (De Souza Filho et al, 2013). Roundup R was shown to affect hematological response and tissue AChE activity in carp (C. carpio) (GholamiSeyedkolaei et al, 2013;Kondera et al, 2018), increased glycogen and triacylglycerol consumption and lipid deposition in the liver, as well as changes in muscle glycogen in catfish (Rhamdia quelen) (Persch et al, 2018), DNA strand breaks in the goldfish (Carassius auratus) (Çavas and Könen, 2007;Lushchak et al, 2009;Li et al, 2017). Cytotoxicity by oxidative stress by Roundup R has been shown by transcriptomic profiling in carp and zebrafish (Uren Webster and Santos, 2015;Sulukan et al, 2017).…”

Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

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Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

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“…Since the presence of ATZ in water resources is due to the agricultural use of the commercial formulations, investigation of the genotoxicity and other biological effects of cATZ seem more relevant. Studies have also described hepatic and renal damage induced by ATZ [13][14][15], showing that these organs are important metabolizing sites of this herbicide [16][17][18][19]. Nevertheless, works on renal and hepatic recovery after long-term exposure to ATZ are scarce, being conducted mainly in common carp [13,16].…”

Section: Introductionmentioning

confidence: 99%

Effects of sublethal and realistic concentrations of the commercial herbicide atrazine in Pacu (Piaractus mesopotamicus): Long-term exposure and recovery assays

et al. 2020

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Background and Aim: The commercial formulations of the herbicide atrazine (cATZ) are widely employed in Brazilian agriculture, and, as a consequence, ATZ has been found at levels above that established by law in the river basins in Brazil. Although the toxicity of ATZ in fish is well documented, there are few studies on the recovery capacity after cATZ exposure. This work aimed to evaluate, using several biomarkers, the toxic effects of long-term exposure to the sublethal (3.57 mg/L) and nonlethal realistic (3.00 μg/L) cATZ concentrations followed by a recovery assay, in fingerlings of a Brazilian teleost, the Piaractus mesopotamicus (pacu). Materials and Methods: Pacu fingerlings were housed in glass tanks and divided into the following experimental groups (two tanks/group): Exposure control = EC, recovery control = RC, the sublethal groups exposed to 3.57 mg/L of cATZ, (sublethal exposure group = SLE and sublethal recovery group = SLR) and the nonlethal groups treated with 3.00 μg/L of cATZ (nonlethal exposure group = NLE and nonlethal recovery group = NLR). The exposure assay was semi-static with a duration of 30 days and the recovery assay (after cATZ withdrawal) lasted 14 days. Several biomarkers were evaluated in fingerlings from all groups: The swimming behavior, the body weight gain, the micronucleus formation and nuclear alterations in erythrocytes, and the hepatic and renal histopathology analyzed by qualitative and semi-quantitative morphological methods (using light and electron microscopy). Results: No significant difference in weight gain was observed among the groups after the exposure and recovery assays. The sublethal exposure induced impaired swimming movements, significant histopathological alterations, including necrosis in the liver and kidney, and a significant increase in the frequency of micronuclei in erythrocytes. The nonlethal exposure induced only subtle histopathological changes in the liver and kidney. After recovery assay, no genotoxic alteration was noted in pacu exposed to sublethal concentration, while the cATZ-induced kidney damage was partially reversed but not the hepatic injury. Conclusion: cATZ exhibits long-term toxic effects on pacu, even at relatively low concentrations, affecting mainly the liver and the kidney, and the effects of sublethal concentration are only partially reversed after cATZ withdrawal.

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“…In Brazil, the 65 µg•L −1 maximum limit concentration in superficial waters was determined by the National Council of Environment-Conama by resolutions #357/2005 and #20/1986. According to the Brazilian Ministry of Health Ordinance #518/2004, the maximum permissible concentration of Glyphosate in drinking water destined for human consumption is 500 µg•L −1 [71], similar to the high concentrations set by Environmental Protection Agencies in the United States [72], European Union [73], and Australia [74], where limits for drinking water are 700 µg•L −1 , 0.1 µg•L −1 , and 1000 µg•L −1 , respectively. This problem has been reported in Brazil [75,76].…”

Section: Resultsmentioning

confidence: 99%

Impact of Pesticides on Human Health in the Last Six Years in Brazil

Lopes-Ferreira

Maleski

Balan-Lima

et al. 2022

IJERPH

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Every year, Brazil intensifies its activity in agriculture and, as a result, it has become one of the biggest consumers of pesticides in the world. The high rate of these substances raises environmental and human health concerns. Therefore, we collected papers from PubMed, Scopus, Scielo, and Web of Science databases, from 2015 to 2021. After a blind selection using the software Rayyan QCRI by two authors, 51 studies were included. Researchers from the South and the Southeast Brazilian regions contributed to most publications, from areas that concentrate agricultural commodity complexes. Among the pesticides described in the studies, insecticides, herbicides, and fungicides were the most frequent. The articles reported multiple toxic effects, particularly in rural workers. The results obtained can be used to direct policies to reduce the use of pesticides, and to protect the health of the population.

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Changes in intermediate metabolism and oxidative balance parameters in sexually matured three-barbeled catfishes exposed to herbicides from rice crops (Roundup ® , Primoleo ® and Facet ® )

Cited by 17 publications

References 49 publications

Re-registration Challenges of Glyphosate in the European Union

Re-registration Challenges of Glyphosate in the European Union

Effects of sublethal and realistic concentrations of the commercial herbicide atrazine in Pacu (Piaractus mesopotamicus): Long-term exposure and recovery assays

Impact of Pesticides on Human Health in the Last Six Years in Brazil

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