Changes in Inflammatory and Metabolic Parameters After Periodontal Treatment in Patients With and Without Obesity

Altay, Umut; Gürgan, Cem A.; Ağbaht, Kemal

doi:10.1902/jop.2012.110646

Cited by 72 publications

(152 citation statements)

References 52 publications

(65 reference statements)

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“…To our knowledge, this is the first randomized clinical trial that included a control group that did not receive any form of periodontal treatment (negative control), which allowed us to estimate the real magnitude of the effect of NSPT in obese CP patients. Previous studies compared the effects of periodontal treatment in obese and nonobese participants with CP and found improved clinical periodontal characteristics at follow-up in both groups after full-mouth scaling and root planing (19,(25)(26)(27)(28). In the present study, participants in the control group were assured that they would be given periodontal treatment at the end of the trial.…”

Section: Discussionmentioning

confidence: 66%

“…Several studies (23)(24)(25)(26)(27) have examined periodontal outcomes after nonsurgical periodontal treatment (NSPT) for CP in obese patients. Although some studies reported that obesity did not affect clinical attachment gain or probing pocket depth (PPD) reduction after periodontal treatment (25,26,28), other studies showed that patients with a higher body mass index (BMI) had a poorer response to NSPT (19,24).…”

Section: Introductionmentioning

confidence: 99%

“…Although some studies reported that obesity did not affect clinical attachment gain or probing pocket depth (PPD) reduction after periodontal treatment (25,26,28), other studies showed that patients with a higher body mass index (BMI) had a poorer response to NSPT (19,24). It remains to be determined whether NSPT improves periodontal outcomes in obese patients (4).…”

Section: Introductionmentioning

confidence: 99%

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Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

et al. 2017

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This study investigated changes in periodontal outcomes after nonsurgical periodontal treatment (NSPT) and evaluated associations of change in salivary resistin level with periodontal outcomes in obese Malaysians with chronic periodontitis. Sixty-two obese adults with chronic periodontitis were randomly divided into a test group (n = 31), which received NSPT, and a control group (n = 31), which received no treatment. Plaque score (PS), gingival bleeding index (GBI), probing pocket depth (PPD), and clinical attachment loss (CAL) were measured at baseline and at 6 and 12 weeks after NSPT. Salivary resistin levels were evaluated by using an enzyme-linked immunosorbent assay. PS was significantly lower in patients who received NSPT than in the control group at 6 and 12 weeks (P < 0.05). In the NSPT group the percentages of sites with shallow and moderate pockets decreased significantly, but there was no significant change in deep pockets. Resistin levels significantly decreased after NSPT (P < 0.05). Change in salivary resistin level was not significantly associated with periodontal outcomes. In obese Malaysians, NSPT significantly improved PS and GBI, and improved PPD and CAL for shallow and moderately deep pockets but not for deep pockets. Salivary resistin level was not associated with improvement in either periodontal variable.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

et al. 2017

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“…This was in agreement with our results which also showed a decrease in the CRP levels after treatment in obese individuals with periodontitis. Conversely, other studies did not verify significant alterations in CRP concentrations after periodontal therapy in normal-weight patients (17,46,47) or obese individuals (17). According to Yamazaki et al, the lack of statistical significance in verifying alterations in CRP may be related to the small number of patients or other methodological limitations (47).…”

Section: Discussionmentioning

confidence: 99%

“…Some findings show that periodontal therapy does not alter metabolic parameters in obese or non-obese patients (16,17), with the exception of TGR (17). The available evidence regarding the relationship between lipid profile and obesity and chronic periodontitis are still controversial and scarce, and well-designed clinical studies assessing the response to periodontal therapy in such patients are necessary in order to better clarify this relationship.…”

Section: Introductionmentioning

confidence: 99%

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Zuza¹,

Barroso²,

Fabricio³

et al. 2016

J Oral Sci

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Periodontal treatment may improve the metabolic control of dyslipidemia. The aim of this study was to evaluate the lipid profile and high-sensitivity C-reactive protein (hs-CRP) levels in obese and non-obese patients undergoing periodontal therapy. Patients with generalized chronic periodontitis were divided into obese (n = 28) and non-obese groups (n = 26). The periodontal parameters (visible plaque index, gingival bleeding index, probing depth, clinical attachment level, and bleeding on probing), anthropometric measurements (body mass index, waist circumference, and body fat), and serum analyses (triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, fasting glucose, glycated hemoglobin, and hs-CRP) were measured at baseline and 90 days after periodontal treatment. The results showed that the obese subjects presented alterations in triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP at baseline when compared with non-obese patients (P < 0.05). Periodontal treatment could improve the periodontal parameters in both groups similarly (P > 0.05). Obese subjects showed a significant decrease in the levels of triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP post-therapy (P < 0.05), while non-obese patients showed improvement only in hs-CRP (P < 0.05). In conclusion, periodontal treatment could improve the periodontal parameters and circulating hs-CRP in obese and non-obese subjects. Lipid profile was modified only in obese patients post-therapy. (J Oral Sci 58, [423][424][425][426][427][428][429][430] 2016)

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Periodontitis and Systemic Diseases

Vaithilingam

Baharuddin

2023

Immunology for Dentistry

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Changes in Inflammatory and Metabolic Parameters After Periodontal Treatment in Patients With and Without Obesity

Abstract: The non-surgical periodontal treatment causes a decrease in the levels of some circulating proinflammatory cytokines and may be associated with a decrease in insulin resistance in the obese population.

Cited by 72 publications

References 52 publications

Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Periodontitis and Systemic Diseases

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