Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats

Wang, R.; Tang, Yi; Feng, Bo; Ye, Chen; Fang, Lingling; Zhang, L.; Li, L.

doi:10.1016/j.neuroscience.2007.07.065

Cited by 78 publications

(50 citation statements)

References 36 publications

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“…Then, the samples was rinsed by 100% acetone three times (15 min for each time) at room temperature, and sliced into ultrathin sections (about 60 nm in thickness) with ultra-microtome, and 3% uranyl acetate -lead citrate was applied for double staining [35]. Observed under an electron microscope, we took photos of the hippocampal synapses in CA1 region at 40,000 times and counted the number of synapses within six random fields per group.…”

Section: Collection Of Brain Sample For Electron Microscopy Observationmentioning

confidence: 99%

Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

Yin

Chen

et al. 2015

Behavioural Brain Research

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Section: Collection Of Brain Sample For Electron Microscopy Observationmentioning

confidence: 99%

Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

Yin

Chen

et al. 2015

Behavioural Brain Research

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“…However, hepatotoxic effects of the herbal product remain unclear as experimental and clinical studies with regulated and strict controls have not been attempted to date. In contrast to these unfavorable reports on humans, PM extracts have been reported to elicit various beneficial effects in experimental animals; [10][11][12][13] viz., the extracts promote hair growth in the hair-loss mouse model, 10) ameliorates behavioral abnormalities and biochemical parameters in the experimen-C 2009 The Pharmaceutical Society of Japan tal Alzheimer's disease model (induced by amyloid β-treatment 12) and attenuates carbon tetrachloride (CCl 4 )-induced liver dysfunction. 13) PM extracts may serve as a useful ingredient in herbal products, and it contains multivariate pharmacologically active principles, such as polyphenolic compounds, minerals and other organic/inorganic components.…”

Section: Introductionmentioning

confidence: 87%

Hot-water-extracts of Polygonum Multiflorum Do Not Induce Any Toxicity but Elicit Limited Beneficial Effects on the Liver in Mice

Noda

Yamada

Ohkubo

et al. 2009

JOURNAL OF HEALTH SCIENCE

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Shou-Wu-Pian, a herbal remedy formulated from Polygonum multiflorum (PM), has been extensively used for the treatment of hair-loss, constipation and vertigo in Asia, Europe and U.S.A. Although recent reports have indicated severe liver damage occurred after taking Shou-Wu-Pian in humans, studies on the hepatotoxicity of this herbal remedy have been limited, and this organ-specific adverse effect induced by PM intake remains to be confirmed. In this study, hepatotoxicity of hot-water-extracted PM was investigated in vitro and in vivo in mice. After treating primary cultured hepatocytes with PM extracts at 3 final concentrations (0.5, 1 and 5 mg/ml) with or without acetaminophen (10 mM) for 24 hr, no cytotoxic effects were observed. In fact, cell viability and lactate dehydrogenase leakage were significantly improved at the highest PM extracts dose compared with controls. Mice orally administered twice daily with the PM extracts (20 or 340 mg extracts/mouse × 2) for 10 days indicated no unfavorable effect on the liver function. Only when mice subchronically received the higher dose of the PM extracts (340 mg) before treatment with a single-bolus dose of acetaminophen (500 mg/kg; i.p.), attenuation of acetaminophen-induced hepatotoxicity was significantly established in vivo. The results in the present study contradicted hepatotoxic findings reported in humans; PM extracts do not induce any toxicological effects, at least on the liver, and may in fact elicit useful but limited beneficial effects on the liver in vivo.

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“…TSG increased choline acetyl transferase activity and improved M-cholinergic receptor binding in the hippocampus and cortex. TSG also increased acetylcholinesterase( AChE) activity in the cortex [59] . Authors also observed changes of cholinergic system in a rat AD model induced by ibotenic acid injection into the basal forebrain; acetylcholine deficiency in AD rats was enhanced by TSG intervention [60] .…”

Section: Tsg On Acetylcholine Deficiencymentioning

confidence: 99%

“…Morris water maze and passageway water maze tests were performed on aged rats. TSG improved learning and memory performances, protected neuronal synaptic structures [69] , and enhanced synaptophysin expression in the hippocampus of aged rats [59] . Researchers identified effects of TSG on memory capabilities and movement functions in aged mice, and further mechanisms.…”

Section: Tsg On Amyloid Cascadementioning

confidence: 99%

Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

Chen¹,

Chen

Wang

et al. 2016

International Journal of Neurology Research

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Current strategies for Alzheimer's disease (AD) treatment are mainly symptomatic; development of disease-modifying therapies is urgently needed. Polygonum Multiflorum has been used in Traditional Chinese Medicine for long history in treatment of dementia. Pharmacological studies suggested Polygonum Multiflorum could improve learning and memory abilities in animal models of AD, and inhibit β-amyloid (Aβ) production in the brain. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside(TSG) is one main bioactive stillbene glycoside of Polygonum Multiflorum. The role of TSG in AD treatment has been investigated recently. TSG might antagonize acetylcholine deficiency and cognitive performance impairment in animal models of AD. In β-amyloid precursor protein (APP) transgenic mice, TSG ameliorated learning and memory functions associated with reductions of senile plaques and Aβ, and inhibitions of γ-secretase and α-synuclein. In Aβ injection rat model, TSG increased cognitive behavior performances, and prevented Aβ deposition and synaptic degeneration. In D-galactose induced aging model, TSG improved abilities of learning and memory, and inhibited expressions of APP and Aβ. Learning and memory deterioration in aged animals was reformed by TSG intervention; its effects may be exerted through APP pathway. TSG also displayed antioxidant activity in vitro and in vivo. In conclusion, TSG has been demonstrated to improve cognitive performances of AD models through multiple target strategies, and may be a future perspective in development of AD therapy.

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Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats

Cited by 78 publications

References 36 publications

Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

Hot-water-extracts of Polygonum Multiflorum Do Not Induce Any Toxicity but Elicit Limited Beneficial Effects on the Liver in Mice

Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

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