Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

Asiaticoside induces osteogenic differentiation of human periodontal ligament cells through the Wnt pathway

“…It was found to inhibit the formation of hypertrophic scars and keloid via TGF‐β/Smad pathway . The protective effect of asiaticoside against cognitive dysfunctions associated with diabetes has been related to the PI3K/Akt/http://NF-κB pathway . We now show that asiaticoside typically activated Wnt signaling as confirmed by an increased accumulation of β‐catenin in the nucleus.…”

Preparation of asiaticoside-loaded coaxially electrospinning nanofibers and their effect on deep partial-thickness burn injury

“…Previous studies had also shown that the asiaticoside had antidepressant-like effect, which was entirely inhibited by pharmacological inhibition of brain-derived neurotrophic factor (BDNF) signaling in behavioral experiments [6]. In addition, some studies demonstrated that asiaticoside had restore synaptic function to improve the learning and memory abilities in diabetic rats, which may be attributed to its anti-diabetic and modulating PI3K/Akt/GSK-3 pathway [3]. However, the most important pharmacodynamics action of asiaticoside is its improved effect on burn healing.…”

“…Asiaticoside, a major triterpenoid component derived from Centella asiatica (L.), has been widely used in wound healing [2], antioxidant [3], immunomodulatory [4] and anti-inflammatory activities [5]. Previous studies had also shown that the asiaticoside had antidepressant-like effect, which was entirely inhibited by pharmacological inhibition of brain-derived neurotrophic factor (BDNF) signaling in behavioral experiments [6].…”

Retracted: Down‐regulated long non‐coding RNA ANRIL restores the learning and memory abilities and rescues hippocampal pyramidal neurons from apoptosis in streptozotocin‐induced diabetic rats via the NF‐κB signaling pathway

“…The swimming time ratio in the target quadrant was utilized in the assessment of the spatial memory of rats. At Day 8,10,12,14,16, and 18 of intervention therapy, the platform was removed and rats were placed into the pool from the target quadrant, facing the pool wall, so that we could observe that rats looking for the platform in 60 s better. Next, the swimming time in the target quadrant from the original platform was calculated.…”