Changes in hepatic mixed-function oxygenase (MFO) activity, plasma steroid levels and age at maturity of a white sucker (Catostomus commersoni) population exposed to bleached kraft pulp mill effluent

McMaster, Mark E.; Kraak, Glen J. Van Der; Portt, Cameron B.; Munkittrick, Kelly R.; Sibley, Paul K.; Smith, Ian R.; Dixon, D. George

doi:10.1016/0166-445x(91)90073-i

Cited by 236 publications

(200 citation statements)

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“…In the present study plasma testosterone levels increased by 80% and GTH II levels by 30% in response to BNF. These hormonal changes are within the range previously reported to affect reproductive functions in fish (Sivarajah et al, 1978a, b;Thomas, 1990;McMaster et al, 1991;Munkittrik et al, 1991). The study started during the late stage of maturation and sampling was performed after 10 weeks when the fish were spermiating.…”

Section: Discussionsupporting

confidence: 86%

“…In Atlantic croaker PCB also altered the in vitro secretion of gonadotropin from isolated pituitaries. Field investigations on fish living in water polluted with a complex mixture of organic pollutants have also indicated a perturbation in plasma hormone levels which probably caused the observed abnormal reproductive development (Munkittrik et al, 1991;McMaster et al, 1991). In the present study plasma testosterone levels increased by 80% and GTH II levels by 30% in response to BNF.…”

Section: Discussionsupporting

confidence: 58%

See 1 more Smart Citation

Pituitary as a target organ for toxic effects of P4501A1 inducing chemicals

Andersson

Förlin

Olsen

et al. 1993

Molecular and Cellular Endocrinology

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 58%

Pituitary as a target organ for toxic effects of P4501A1 inducing chemicals

Andersson

Förlin

Olsen

et al. 1993

Molecular and Cellular Endocrinology

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“…Reproduetive impairment in fishes exposed to pulp and paper milI effluent has been reported as redueed plasma sex steroid eoneentrations [1,2], decreased egg and gonad size [3][4][5][6], redueed fertilization and hatehing sueeess [7,8J, deereased oeeurrenee of male seeondary sex eharaeteristies, and greater age to matllrity [9]. Some doeumented responses mimie the physiologieal effeets of natural androgens.…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro assessment of the androgenic potential of a pulp and paper mill effluent

Ellis

Heuvel

Bandelj

et al. 2003

Enviro Toxic and Chemistry

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Abstract-The androgenic potential of a New Zealand pulp and paper mill effluent was measured by applying a combinatioll of in vitro and in vivo bioassays with mosquitofish (Gambusia a!finis) and goldfish (Carassius aurarus). The in vivo method assessed the rate of gonopodial development (masculinization) and alterations from normal reproductive behavior in adult female mosqllitofish exposed for 21 d to lIntreated 01' secondary-treated pulp mill effluent. A second in vivo mosquitofish exposure tested the effect of gl ass-fiber (type C) fi Itration of secondary-treated effIlient on rates of expression of the same endpoints. Extractable organics analyses of effluents and extracts thereof were conducted. Mosqllitofish demonstrated significant masculinization on exposure to either treated 01' untreated effluent; the frequency of gonopodial development was reduced with efiluent secondary-treatment. Male mating behavior was observed in the masculinized adult females. Glass-fiber (type F) filtration of the treated effluent eliminated the masclilinizing effect, suggesting that the bioactive compounds were associated with the suspended solids. The in vitra method measlired the binding of compounds within a treated thermomechanicallbleached kraft cffluent extract to androgen receptors contained in goldfish testis cytosol. Exposure to extracts of either the particulate (glass-fiber filtered) 01' the dissolved organic fraction of the efflllent produced significant binding (as indicated by the displacement of radiolabeled testosterone) to the androgen reeeptor in goldfish gonadal tissue. Thus, the dissolved organics extract of the treated effluent contained compounds androgenic to goldfish in vitro but not to mosquitofish in vivo. The combined in vitra and in vivo data suggest that the effluent in question could exert effects on the reproductive physiology of fishes through an androgenic mechanism. The androgenic compounds androstenedione and testosterone were not detected in the extracts used far the in vitro component of this study.

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“…Abnormalities have also been reported in the male reproductive system of fish living in water polluted by sewage or industrial chemicals [12,25]. Studies on the male teleost revealed changes including induced vitellogenin production [5,13,14,20], hermaphroditism as evidenced by the presence of both testicular and ovarian tissues [8,10,11,18,31], reduced testis size [20] and reduced plasma androgen concentrations together with delayed sexual maturity [26].…”

mentioning

confidence: 99%

Gonadosomatic Index and Testis Morphology of Common Carp (Cyprinus carpio) in Rivers Contaminated with Estrogenic Chemicals.

Hassanin

Kuwahara

Nurhidayat

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. To study the effect of estrogenic chemicals on fish, the gonadosomatic index (GSI = [testis weight/body weight] × 100) and testis histology of mature common carp (Cyprinus carpio) from 2 contaminated sites (Ishizu and Wada rivers, Osaka) and a control site were examined between June 1998 and March 2001. The concentration of nonylphenol, bisphenol A and 17β-estradiol in the Ishizu river was 3-4 times higher than in the Wada river. In the pre-breeding and breeding seasons, there were no significant differences in body weight among carp from the 3 sites, the body weight of Ishizu river carp being significantly lower (p<0.05) than that of Wada river fish only in the post-breeding season. The GSI and testis weight in fish from the Ishizu river were significantly lower (p<0.05) than in control fish during all phases of gonadal cycle and lower than in Wada river fish in the pre-breeding and post-breeding season. No histological abnormalities were found in the testes of the males examined. Histological observation of the testes revealed a delay in the onset of spermatogenesis in fish from the Ishizu river compared with those from the other sites. These results clearly imply that the estrogenic chemicals in the Ishizu river adversely affect the testis development of the fish. There is growing evidence in support of the claim that contamination of a wildlife population with estrogenic chemicals can disturb the reproductive function of vertebrates [6,7,12]. Many researches have been focused on fish, since as aquatic inhabitants they receive sewage or industrial effluent and agricultural runoff containing estrogenic chemicals [5,14,30]. In fish, estrogenic responses have been associated with exposure to pesticides [3,35], pulp mill effluents [23,29,34], plasticizers [19] and sewage effluent [2,17,31]. Abnormalities have also been reported in the male reproductive system of fish living in water polluted by sewage or industrial chemicals [12,25]. Studies on the male teleost revealed changes including induced vitellogenin production [5,13,14,20], hermaphroditism as evidenced by the presence of both testicular and ovarian tissues [8,10,11,18,31], reduced testis size [20] and reduced plasma androgen concentrations together with delayed sexual maturity [26].Some information is known on the effect of estrogens and estrogenic chemicals on the carp testis, and their relation to seasonal changes in testis morphology. Three-month exposure to a sublethal dose of 4-tert-pentylphenol or 17β-estradiol causes progressive disappearance of spermatozoa and spermatogenic cysts, and reduces the seminiferous tubule diameter, in mature male carp [11]. Ovo-testes were found in juvenile carp exposed to xeno-estrogens during sexual differentiation [8,9]. However, a field study on adult crucian carp (Carassius carassius) living in a pond containing treated pulp mill effluent showed no gonadal deformation or feminization of male gonads [23]. It is therefore important to study the testis of mature male carp (Cyprinus carpio) living in rivers ...

show abstract

Changes in hepatic mixed-function oxygenase (MFO) activity, plasma steroid levels and age at maturity of a white sucker (Catostomus commersoni) population exposed to bleached kraft pulp mill effluent

Cited by 236 publications

References 40 publications

Pituitary as a target organ for toxic effects of P4501A1 inducing chemicals

Pituitary as a target organ for toxic effects of P4501A1 inducing chemicals

In vivo and in vitro assessment of the androgenic potential of a pulp and paper mill effluent

Gonadosomatic Index and Testis Morphology of Common Carp (Cyprinus carpio) in Rivers Contaminated with Estrogenic Chemicals.

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