Changes in hemodynamics and respiration in rats with different resistance to acute hypoxia

Sanotskaya, N. V.; Мациевский, Д. Д.; Lebedeva, M. A.

doi:10.1007/bf02694463

Cited by 7 publications

(10 citation statements)

References 4 publications

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“…However, the amplitude of respiratory movements remained above the normal in this period. This type of breathing was previously revealed in HR rats with severe acute hypoxia produced by long-term breathing a hypoxic mixture [8]. The respiratory rate in 3 particularly resistant rats decreased, but returned to normal 20-30 min after repeated administration of lithium hydroxybutyrate.…”

Section: Resultsmentioning

confidence: 72%

“…Our previous studies showed that after repeated breathing a hypoxic gas mixture (3% O 2 ) not accompanied by administration of lithium hydroperoxide, most HR rats retain high resistance to hypoxia. Some HR animals became IR, but nor LR [8].…”

Section: Resultsmentioning

confidence: 97%

“…The individual resistance of animals to hypoxia was estimated during inspiration of a gas mixture containing 3% O 2 and nitrogen by the latency of apnea [8,9]. Gas mixture supply was then stopped and if breathing did not restore spontaneously within 1-1.5 min artificial lung ventilation was started.…”

Section: Methodsmentioning

confidence: 99%

“…Lung ventilation was stopped with the appearance of breathing. The animals with apnea latency of 1-4, more than 9, and 5-8 min after the start of hypoxic exposure were classified as LR, HR, and intermediate resistant (IR), respectively [2,8]. Twenty-two rats repeatedly breathed the gas mixture 30-40 min after treatment with lithium hydroxybutyrate to estimate its effect on the resistance to acute hypoxia.…”

Section: Methodsmentioning

confidence: 99%

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Effect of lithium hydroxybutyrate on hemodynamics and respiration in rats with different resistance to hypoxia

2006

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Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of lithium hydroxybutyrate on hemodynamics and respiration in rats with different resistance to hypoxia

2006

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“…Phase 2 of severe hypoxia is followed by a reversible respiratory arrest (apnea). The latency of apnea is considered as the lifespan [2,4,5]. The mechanisms of apnea during severe hypoxia remain unknown [6].…”

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confidence: 99%

Effect of picrotoxin on organism’s resistance to acute severe hypoxia

2008

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Organism's resistance to acute severe hypoxia (3% O2) was studied after administration of GABA(A) receptor antagonist picrotoxin and adenosine receptor antagonist euphylline (aminophylline) and after neutralization of secondary hypocapnia by adding 7% CO2 to the hypoxic mixture. Administration of picrotoxin to anesthetized rats increased animal resistance to hypoxia. The resistance to hypoxia decreased after treatment with euphylline. Neutralization of secondary hypocapnia by adding 7% CO2 to the hypoxic mixture had no effect on animal lifespan.

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Mechanisms of Vasoprotection and Cardioprotection in Hypoxytherapy of Arterial Hypertension and Coronary Artery Disease

Ignatenko

2024

Kompleks. probl. serdečno-sosud. zabol.

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Highlights The article presents a modern understanding of the main links of the functional circulatory regulation system and its response to exogenous hypoxia, as well as describes the data available on molecular mechanisms of vasoprotection and cardioprotection involved in response to hypoxytherapy in patients with arterial hypertension and coronary artery disease. AbstractHypoxic conditioning has taken an important place in the range of non-drug methods for stimulating the adaptive potential of a healthy person and patients with cardiovascular diseases. There are many approaches to the use of various methods of exogenous hypoxia, however, there is no consensus on the essence of sanogenetic mechanisms that provide a multi-level functional system for maintaining oxygen supply and blood circulation. Adaptive reactions of afferent, central and efferent links of the functional circulatory regulation system in hypoxia in a healthy person are described. The results of studies of physiological systemic reactions realized by respiratory and vegetative plasticity using interval (intermittent) hypoxia are presented. In patients with arterial hypertension and coronary artery disease, the facts of chemoreflective stimulation and modulation of lung ventilation, autonomic nervous system status, especially sympathetic activity of peripheral blood vessels and vagal activation of cardiac activity have been established. The main vaso- and cardioprotective properties of interval hypoxytherapy are based on the leveling of oxidative stress, inflammation, activation of angiogenesis, and a shift in the secretory activity of the endothelium towards vasodilating, antiproliferative, and antithrombotic mediators. We present the evidence for the role of shear stress and the state of glycocalyx, angiopoietin and adrenomedulline in the regulation of vascular tone, as well as cytoprotective properties of cytoplasmic and mitochondrial metabolic factors in the formation of ischemic tolerance of cardiomyocytes. The issues of the relationship between systemic (neuronal and humoral) reactions and structural and functional responses of target cells in providing adaptive/compensatory mechanisms for regulating blood circulation under the influence of exogenous hypoxia require further research and evaluation.

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Changes in hemodynamics and respiration in rats with different resistance to acute hypoxia

Cited by 7 publications

References 4 publications

Effect of lithium hydroxybutyrate on hemodynamics and respiration in rats with different resistance to hypoxia

Effect of lithium hydroxybutyrate on hemodynamics and respiration in rats with different resistance to hypoxia

Effect of picrotoxin on organism’s resistance to acute severe hypoxia

Mechanisms of Vasoprotection and Cardioprotection in Hypoxytherapy of Arterial Hypertension and Coronary Artery Disease

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