Effect of picrotoxin on organism’s resistance to acute severe hypoxia

Sanotskaya, N. V.; Мациевский, Д. Д.; Lebedeva, M. A.

doi:10.1007/s10517-008-0043-4

Cited by 5 publications

(8 citation statements)

References 9 publications

(14 reference statements)

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“…Mean values of the resistance to hypoxia in the control pre-tested rat groups are shown in Figure 1. In our study, the rats with low, intermediate and high resistance to SHBH comprised 36%, 27% and 38%, respectively, of the tote pre-tested rats (n = 64), which corresponds to the usual composition of outbred rats in an experimental lot [28] [32]. (Figure 1(a) and Figure 1(b)).…”

Section: Resistance To Shbh Of the Intact High And Low Resistance Ramentioning

confidence: 74%

Hypoxic Preconditioning Eliminates Differences in the Innate Resistance of Rats to Severe Hypoxia

Захарова¹,

Dudchenko²

2016

JBiSE

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Hypoxic preconditioning is able to increase the body's resistance to hypoxic/ischemic stress. Understanding how to apply the hypoxic response to initiate the protective mechanism of ischemic preconditioning is a high priority. However, the relationship between innate resistance to hypoxic stress and preconditioning efficiency of moderate hypoxia has been poorly studied. In our work, the efficiency of single moderate hypobaric hypoxia (HBH) for resistance to severe hypobaric hypoxia (SHBH) was studied on intact rats and those pre-tested under SHBH with low, intermediate and high resistance to hypoxia. HBH has a significant preconditioning action on the resistance to hypoxia over a wide range from 270 to 1464 s (4.5 to 24.5 min) and at the same time eliminates the differences in the endurance under SHBH between all rat groups. It is concluded that 1) HBH preconditioning efficiency does not depend on an innate resistance to SHBH and prior hypoxic experience of rats; and 2) the pretesting to severe hypoxia has no value for predicting the hypoxic preconditioning efficiency and study of adaptive mechanisms.

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Section: Resistance To Shbh Of the Intact High And Low Resistance Ramentioning

confidence: 74%

Hypoxic Preconditioning Eliminates Differences in the Innate Resistance of Rats to Severe Hypoxia

Захарова¹,

Dudchenko²

2016

JBiSE

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“…A severe hypoxia (3% O 2 , rat) in the first few minutes, like in the moderate hypoxia, initiated the same dynamics in the increase of minute tidal volume and respiratory frequency [40][41][42], and picrotoxin (i.v.) significantly potentiated the activation of both respiratory functions (cat and rat) [42]. Also, the authors observed that these effects of picrotoxin were most pronounced in the high resistance rats compared with low and intermediate resistance rats.…”

Section: Gabaergic Systemmentioning

confidence: 73%

“…administration of GABA A receptor antagonist picrotoxin enhanced ventilation through an increase in respiratory frequency and minute tidal volume (rat) [42]. A severe hypoxia (3% O 2 , rat) in the first few minutes, like in the moderate hypoxia, initiated the same dynamics in the increase of minute tidal volume and respiratory frequency [40][41][42], and picrotoxin (i.v.) significantly potentiated the activation of both respiratory functions (cat and rat) [42].…”

Section: Gabaergic Systemmentioning

confidence: 99%

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Hypoxic Preconditioning: The Multiplicity of Central Neurotransmitter Mechanisms and Method of Predicting Its Efficiency

Захарова¹,

Storozheva²,

Proshin³

et al. 2018

Hypoxia and Anoxia

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In rats, a single moderate hypobaric hypoxia (HBH) increased the resistance to severe hypoxia (SHBH). The HBH efficiency and neurotransmitter mechanisms of its preconditioning action were investigated by biochemical and pharmacological methods. It will be substantiated in the chapter: (1) HBH preconditioning has its own mechanisms that do not depend on an innate resistance to SHBH and prior hypoxic experience of rats; (2) the same preconditioning effect can be achieved by diverse neuronal pathways and synaptic plasticity means; (3) cholinergic and, presumably, serotoninergic, GABAergic and/or glutamatergic systems of the caudal brainstem, cortex and some other brain structures are involved in HBH realisation; (4) the rate of sensorimotor gating estimated in the model of acoustic startle pre-pulse inhibition (PPI) predicts the efficiency of hypoxic preconditioning and (5) the cholinergic system, including α7 nicotinic receptors, is involved in the mechanisms of HBH-PPI-dependent preconditioning effects.

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“…We used high-frequency ultrasonic Doppler system working at a frequency of 33 MHz for recording blood fl ow velocity in rat a. basilaris without opening the skull. We used an invasive methodology used for central injection through the occipital membrane into the cavity of the cerebral ventricle IV [6]. The aim of our experiment was to evaluate the effi ciency of this approach in studies of the hemodynamics in the cerebral basilar arteries.…”

mentioning

confidence: 99%

Transcranial Evaluation of Blood Flow Velocity in the Basilar Artery in Rats by High Frequency Ultrasonic Doppler Technique

2009

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The possibility of recording the blood flow velocity in the basilar artery (a. basilaris) in rats through the occipital membrane by a two-channel ultrasonic Doppler system with single-element transducers was demonstrated. A. basilaris was located with a contact transducer working at a frequency of 33 MHz in two modes: pulsed and permanent. The mean blood flow velocity in narcotized male Wistar rats was 4.93+/-0.78 cm/sec. Functional loading tests (acute elevation of blood pressure and occlusion of the common carotid arteries) showed that this method allows recording dynamic characteristics of the blood flow reactions in a. basilaris with evaluation of its pulse wave pattern and analyzing their correlations with blood flow parameters in the carotid arteries using simultaneously the second (bandage) transducer.

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Effect of picrotoxin on organism’s resistance to acute severe hypoxia

Cited by 5 publications

References 9 publications

Hypoxic Preconditioning Eliminates Differences in the Innate Resistance of Rats to Severe Hypoxia

Hypoxic Preconditioning Eliminates Differences in the Innate Resistance of Rats to Severe Hypoxia

Hypoxic Preconditioning: The Multiplicity of Central Neurotransmitter Mechanisms and Method of Predicting Its Efficiency

Transcranial Evaluation of Blood Flow Velocity in the Basilar Artery in Rats by High Frequency Ultrasonic Doppler Technique

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