Changes in haemoglobin and haematocrit values in children aged 6 to 13 1/2 years in Mexico city

Parra, Adalberto; Argote, Rosa Ma.; Garcia, Guadalupe; Fletes, Ladislao; Cervantes, C. Escobar; Arias, Raúl; Garcia-Peña, J.

doi:10.1080/03014467600001801

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…In fact, a significant quadratic relationship was seen between them, and the excretion of these compounds increased at a faster rate approxima¬ tely after 130.0-135.0 cm. The latter figure is quite similar to the height (138.0 cm) previously reported by our group, when haemoglobin and haematocrit increased in children (Parra et al 1976) and also when significant changes in the plasma concentrations of different thyroid hor¬ mones do occur (Parra et al 1980). This faster increase in the urinary output of these compounds might be the result of an increased release or degradation of catecholamines and its physiological consequence remains to be explained.…”

Section: Discussionsupporting

confidence: 86%

Urinary excretion of catecholamines in healthy subjects in relation to body growth

Parra¹,

Angel²,

Cervantes³

et al. 1980

Acta Endocrinologica

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The daily urinary excretion of dopamine (DA), noradrenaline (NA) and adrenaline (A) was investigated in 43 clinically healthy males and 37 females, aged 13 days to 37.5 years. There was a progressive increase in the daily output of each catecholamine (\g=m\g/24 h) with increasing age (P < 0.025 to <0.001), and the opposite was seen when values were expressed as \g=m\g/g creatinine (P < 0.05 to <0.025). However, when values were expressed as \g=m\g/m2/24 h no significant differences were disclosed among the different age groups, except for a transient rise in DA excretion in the group 1.0-4.9 years. A significant linear correlation was observed between chronological age and urinary DA (r = 0.814, P < 0.05), NA (r = 0.837, P < 0.05) and A (r = 0.839, P < 0.05), and also between body weight and each one of the catecholamines (DA: r = 0.731, P <0.05; NA: r = 0.839, P < 0.05; A: r = 0.720, P < 0.05). However, a quadratic correlation existed between height and DA (r = 0.759, P< 0.05), NA (r = 0.853, P< 0.05) and A (r = 0.814, P < 0.05). Each one of these models could explain up to 73% of the observed variability. It is suggested that: a) the most convenient form to express the daily urinary excretion of catecholamines is as \g=m\g/m2/24 h; b) the excretion of these compounds increased at a faster rate approximately after 130.0\p=m-\135.0cm of height; c) this height-related greater increase in the output of catecholamines occurs simultaneously with previously reported increases in haemoglobin and haematocrit and significant changes in plasma concentrations of thyroid hormones; d) although the mechanisms involved in these changes remain to be clarified, it is interesting to note that they occur at a time when oxygen requirements are greater consecutive to the rapid increase of lean body tissues.Quantitation of the daily urinary excretion of cate¬ cholamines and their metabolites is of great value in the diagnosis and management of neuroblastoma, ganglioneuroma and phaeochromocytoma.Nevertheless, data on the urinary excretion of dopamine (DA), noradrenaline (NA) and adre¬ naline (A) in healthy children is scanty and incom¬ plete (Kärki 1957;Cession-Fossion et al. 1964;Voorhess 1967;Comoy & Bohuon 1970;Borrell et al. 1974;De Schaepdryver et al. 1978). Further¬ more, the normal data available are difficult to compare to each other, not only because of the different methodology used, but also because of the lack of uniformity in expressing the results. The urinary excretion of catecholamines (as ng) has been referred to as an absolute value in 24 h, or per m2 of body surface, per kg body weight or per g of urinary creatinine. Each investigator has claimed reasons in favour of each form of express¬ ing the results. However, it is clear that: 1) chrono¬ logical age and body weight have a moderate importance (at best) as indicators of biological age,

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Section: Discussionsupporting

confidence: 86%

Urinary excretion of catecholamines in healthy subjects in relation to body growth

Parra¹,

Angel²,

Cervantes³

et al. 1980

Acta Endocrinologica

View full text Add to dashboard Cite

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“…However, such changes do occur whenever girls and boys attain a similar body weight, height or surface area (Table 1), regardless of chronologi¬ cal age (Parra et al 1976). However, such changes do occur whenever girls and boys attain a similar body weight, height or surface area (Table 1), regardless of chronologi¬ cal age (Parra et al 1976).…”

Section: Discussionmentioning

confidence: 99%

Thyroid gland function during childhood and adolescence

Parra

Villalpando

Junco

et al. 1980

Acta Endocrinologica

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Serum thyrotrophin (TSH), thyroxine (T4), triiodothyronine (T3), thyroxine-binding globulin (TBG) and reverse T3 (rT3) were measured by radioimmunoassay in 175 girls and 187 boys aged 6.0 to 16.9 years, who were clinically healthy, and had negative serum antithyroglobulin and antimicrosomal antibodies. All the children had normal weight and height and were grouped at 12 months' intervals. In girls, TSH levels ranged between 5.3 \ m=+-\ 0.4 and 6.9 \ m=+-\ 0.5 \g=m\U/mlwithout significant changes with age; serum T4 decreased up to 13.9 years and rose afterwards; serum TBG was constant up to 13.9 years, decreased subsequently and rose after 15.9 years; serum T3 levels were lower after 13.0 years than previously; serum rT3 decreased between 11.0 and 11.9 years and rose thereafter; the calculated serum free T4 (FT4) and

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Nutritional Status Improves after Treatment of Schistosoma japonicum-Infected Children and Adolescents

Coutinho

Acosta

McGarvey

et al. 2006

The Journal of Nutrition

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Studies addressing the relation between chronic schistosomiasis japonica and nutritional status are limited. We conducted a longitudinal treatment-reinfection study in Leyte, the Philippines, among 477 Schistosoma japonicum-infected subjects aged 7-20 y, to evaluate changes in nutritional status after treatment with praziquantel. Stool, Tanner stage, anthropometric indices, and hemoglobin (Hb) were evaluated at baseline, 4 wk post-treatment, and every 3 mo for 18 mo. Height-for-age Z-score (HAZ) and BMI Z-score (BMIZ) were calculated. Change scores relative to baseline were created for all outcome measures. Multilevel repeated-measures analyses were used to adjust for socioeconomic status, sex, either pubertal status or age, and household-level clustering. Z-scores improved modestly but significantly over time. BMIZ in children wasted at baseline improved the most [0.41 (0.26-0.56) Z-score unit] and HAZ improved only in children stunted at baseline [0.17 (0.l2-0.21) Z-score unit]. Hb improvement peaked at 15 mo and occurred only in subjects that were anemic at baseline [peak improvement: 8.3 (6.0-10.6) g/L] and in males [peak improvement 4.7 (2.9-6.6) g/L]. Reinfection, evaluated as egg count over time and egg count 3 mo earlier to assess a delay in effect, was inversely associated with improvement in Hb (P = 0.06 and 0.004, respectively). High-intensity reinfection at 18 mo was associated with significantly less absolute growth from baseline compared with lower-intensity and no reinfection. Based on the peak Hb improvement at 15 mo post-treatment, annual treatment intervals are recommended to reduce schistosomiasis-associated nutritional morbidity.

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Changes in haemoglobin and haematocrit values in children aged 6 to 13 1/2 years in Mexico city

Cited by 3 publications

References 11 publications

Urinary excretion of catecholamines in healthy subjects in relation to body growth

Urinary excretion of catecholamines in healthy subjects in relation to body growth

Thyroid gland function during childhood and adolescence

Nutritional Status Improves after Treatment of Schistosoma japonicum-Infected Children and Adolescents

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