Changes in Haematological Indices in Normal Pregnancy

Abstract

Variation in some haematological indices during normal pregnancy was investigated. The test group comprised 200 pregnant women who presented themselves at the Capitol Hill Clinic Warri, Delta State, Nigeria, for antenatal care while the control group comprised 80 nonpregnant women randomly selected from the student population in Delta State University, Abraka. Data generated from the pretest questionnaire indicated that 55.8% of the research participants experienced an increase in appetite. The analysis of haematological indices was done using automated hematological analyzer. The result from the study showed that there was a significant decrease ( < 0.05) in the PCV of the test group (32.58±4.01)% when compared to the control (37.07±3.19)%. Similarly, the result of the blood haemoglobin showed a significant difference ( < 0.05) between the test (10.00 ± 1.28) g/dL and the control group (11.71 ± 1.32) g/dL while granulocytes and platelets also showed significant decrease ( < 0.05) with lymphocytes increasing significantly; the total white blood cell count (WBC) showed no significant difference; there was an increased level compared to the control. The study concluded that pregnancy in women has the tendency to alter haematological indices.

Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women

“…Also this disagrees with the study done by Boehlen et al, reported that there were decreases in platelets count in normal pregnant women. [16,17] Also, our finding agrees with another study done by Ichipi-Ifukor et al, concluded that pregnancy in women alters hematological indices such as packed cell volume, Hb, lymphocyte, and platelet counts during normal pregnancy. [16] The result of this study reveals that PT and PTT showed statistically insignificant differences and this indicates that pregnancy is not likely to have any adverse effect on these parameters.…”

“…[16,17] Also, our finding agrees with another study done by Ichipi-Ifukor et al, concluded that pregnancy in women alters hematological indices such as packed cell volume, Hb, lymphocyte, and platelet counts during normal pregnancy. [16] The result of this study reveals that PT and PTT showed statistically insignificant differences and this indicates that pregnancy is not likely to have any adverse effect on these parameters. This result is consistent with an earlier report by Asaad and Fathelrahman in which the PT and the PTT remains unchanged among pregnant women.…”

Establishment of immunohematological reference values among HIV sero-negative pregnant women at St. Paul’s Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia

“…As one study revealed, there were significant decreases in RBCs count, hemoglobin (Hgb) and packed cell volume (PCV) of pregnant women compared to non-pregnant women. This study also showed total white blood cells count was increased significantly ( 7 ) and increased level of appetite too ( 8 ). Anemia (low hemoglobin) is a widely identified hematological abnormality ( 9 ), and it is associated with adverse pregnancy outcomes ( 10 ).…”

Effect of intra‐cellular trafficking on flow cytometric measurement of neutrophil's oxidative status in iron deficient pregnant females

“…Although the primary focus of our study was neutrophils, we found cases to have a significantly higher absolute lymphocyte count compared to controls ( P =.047). This agrees with Ichipi‐ Ifukor & collegues in 2013 who reported that there is a significant increase in lymphocyte count in pregnant compared to non pregnant. Also this finding agrees with what Luppi in 2003 reported about increase in lymphocyte count in early pregnancy that remains elevated throughout pregnancy.…”