Changes in gut-brain axis parameters in adult rats of both sexes with different feeding pattern that were early nicotine-exposed

Rodrigues, Vanessa Silva Tavares; Moura, Egberto Gaspar de; Peixoto, Thamara Cherem; Soares, P.N.; Lopes, Bruna Pereira; Oliveira, Elaine de; Manhães, Alex C.; Atella, Geórgia C.; Kluck, George Eduardo Gabriel; Cabral, S.S.; Trindade, Patrícia Leticia; Daleprane, Julio Beltrame; Lisboa, Patrícia Cristina

doi:10.1016/j.fct.2021.112656

Cited by 4 publications

(2 citation statements)

References 84 publications

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“…This led to a decrease in the ability of the gut to produce SCFAs and an increase in vagus nerve excitability, resulting in an increased incidence of obesity. 94 At the same time, the decrease in the abundance of Bacteroidetes and the ability to produce SCFAs in the intestine damage the intestinal barrier and increase the incidence of ASCVD and HF through intestinal dependent blood pressure regulation. Thus, it seems that targeting specific gut microbes not only blocks tobacco addiction through gut-brain axis, but also shows great benefits in cardiovascular health via gut-heart axis.…”

Section: Adultmentioning

confidence: 99%

Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation

Shi,

Li,

2024

Gut Microbes

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The gut microbiome is known as the tenth system of the human body that plays a vital role in the intersection between health and disease. The considerable inter-individual variability in gut microbiota poses both challenges and great prospects in promoting precision medicine in cardiovascular diseases (CVDs). In this review, based on the development, evolution, and influencing factors of gut microbiota in a full life circle, we summarized the recent advances on the characteristic alteration in gut microbiota in CVDs throughout different life stages, and depicted their pathological links in mechanism, as well as the highlight achievements of targeting gut microbiota in CVDs prevention, diagnosis and treatment. Personalized strategies could be tailored according to gut microbiota characteristics in different life stages, including gut microbiota-blood metabolites combined prediction and diagnosis, dietary interventions, lifestyle improvements, probiotic or prebiotic supplements. However, to fulfill the promise of a lifelong cardiovascular health, more mechanism studies should progress from correlation to causality and decipher novel mechanisms linking specific microbes and CVDs. It is also promising to use the burgeoning artificial intelligence and machine learning to target gut microbiota for developing diagnosis system and screening for new therapeutic interventions.

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Section: Adultmentioning

confidence: 99%

Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation

Shi,

Li,

2024

Gut Microbes

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“…Shanahan et al ( 2018 ) discovered that either the previous or the current smokers had significantly reduced the bacterial diversity in the upper small intestinal mucosa, which was accompanied by more Firmicutes, Rothia and less Prevotella , and Neisseria . Maternal nicotine exposure via lactating showed decreased Bacteroidetes , increased Firmicultes and Actinobacteria in the feces of the offspring, indicating long-lasting effects of nicotine to change offspring's microbiota and eating behavior, which might predict extra calories intake and diabetes/obesity development (Rodrigues et al, 2021 ). Moreover, a recent study by Hosseini et al ( 2021 ) demonstrated that the smoking-associated changes in microbiome were absent if the smoker quit smoke for more than 10 years, suggesting the necessity for smoking cessation for the purpose of maintaining healthy gut flora.…”

Section: Smokingmentioning

confidence: 99%

How Brain Infarction Links With the Microbiota–Gut–Brain Axis: Hints From Studies Focusing on the Risk Factors for Ischemic Stroke

et al. 2022

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Ischemic stroke (IS) is among the top prevalent neurologic disorders globally today. Risk factors such as hypertension, diabetes, and aging, contribute to the development of IS, and patients with these risk factors face heavier therapeutic burden and worse prognosis. Microbiota–gut–brain axis describes the crosstalk between the gut flora, intestine, and center nervous system, which conduct homeostatic effects through the bacterial metabolites, the regulation of immune activity, also the contact with enteric nerve ends and vagus nerve. Nowadays, more studies have paid attention to the important roles that microbiota–gut–brain axis played in the risk factors of IS. In the current article, we will review the recent works focusing on the bi-directional impacts of gut dysbiosis and the pathogenic process of IS-related risk factors, for the purpose to summarize some novel findings in this area, and try to understand how probiotics could limit the development of IS via different strategies.

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When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development

Chen,

Zeng,

Sun

et al. 2024

Sci. China Life Sci.

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Changes in gut-brain axis parameters in adult rats of both sexes with different feeding pattern that were early nicotine-exposed

Cited by 4 publications

References 84 publications

Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation

Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation

How Brain Infarction Links With the Microbiota–Gut–Brain Axis: Hints From Studies Focusing on the Risk Factors for Ischemic Stroke

When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development

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