When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development

Chen, Bo; Zeng, Guangyi; Sun, Lulu; Jiang, Changtao

doi:10.1007/s11427-023-2446-y

Cited by 2 publications

(1 citation statement)

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“…Additionally, we also found that controlling smoking and engaging in moderate physical activity are important lifestyle factors that reduce the risk of anxiety disorders through interactions with the identified bacterial genera. Indeed, recent studies have reported that tobacco smoke components such as nicotine are present in the gastrointestinal tract and disrupt the gut microbiota ( Chen et al, 2024 ), interfering with vagal nerve signaling and neurotransmission, as well as inducing CNS inflammation, ultimately increasing the risk of mental health illnesses such as depression, schizophrenia, and anxiety disorders ( Curtis et al, 2019 ; Wang et al, 2023 ). Furthermore, prioritizing aerobic physical activity at moderate intensity, rather than prolonged intensity, seems to be useful in regulating the diversity and richness of beneficial bacterial taxa in both humans and animals.…”

Section: Discussionmentioning

confidence: 99%

Improving precision management of anxiety disorders: a Mendelian randomization study targeting specific gut microbiota and associated metabolites

Xu,

Qiu,

et al. 2024

Front. Microbiol.

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BackgroundThere is growing evidence of associations between the gut microbiota and anxiety disorders, where changes in gut microbiotas may affect brain function and behavior via the microbiota-gut-brain axis. However, population-level studies offering a higher level of evidence for causality are lacking. Our aim was to investigate the specific gut microbiota and associated metabolites that are closely related to anxiety disorders to provide mechanistic insights and novel management perspectives for anxiety disorders.MethodThis study used summary-level data from publicly available Genome-Wide Association Studies (GWAS) for 119 bacterial genera and the phenotype “All anxiety disorders” to reveal the causal effects of gut microbiota on anxiety disorders and identify specific bacterial genera associated with anxiety disorders. A two-sample, bidirectional Mendelian randomization (MR) design was deployed, followed by comprehensive sensitivity analyses to validate the robustness of results. We further conducted multivariable MR (MVMR) analysis to investigate the potential impact of neurotransmitter-associated metabolites, bacteria-associated dietary patterns, drug use or alcohol consumption, and lifestyle factors such as smoking and physical activity on the observed associations.ResultsBidirectional MR analysis identified three bacterial genera causally related to anxiety disorders: the genus Eubacterium nodatum group and genus Ruminococcaceae UCG011 were protective, while the genus Ruminococcaceae UCG011 was associated with an increased risk of anxiety disorders. Further MVMR suggested that a metabolite-dependent mechanism, primarily driven by tryptophan, tyrosine, phenylalanine, glycine and cortisol, which is consistent with previous research findings, probably played a significant role in mediating the effects of these bacterial genera to anxiety disorders. Furthermore, modifying dietary pattern such as salt, sugar and processed meat intake, and adjusting smoking state and physical activity levels, appears to be the effective approaches for targeting specific gut microbiota to manage anxiety disorders.ConclusionOur findings offer potential avenues for developing precise and effective management approaches for anxiety disorders by targeting specific gut microbiota and associated metabolites.

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Section: Discussionmentioning

confidence: 99%