Changes in estrogen receptors α and β expression in the brain of mice exposed prenatally to bisphenol A

Kawai, Keisuke; Murakami, Shuji; Senba, Emiko; Yamanaka, T.; Fujiwara, Yuya; Arimura, Chikako; Nozaki, Tomoyoshi; Takii, Michiaki; Kubo, Chiharu

doi:10.1016/j.yrtph.2006.04.002

Cited by 53 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At maturity, more ERα-labelled neurons were found in the medial preoptic area (MPA) in females [32]. Esrl and Esr2 mRNA expression were also increased in the dorsal raphe nucleus (DRN) of male ICR (CD-1) mice prenatally exposed to 2 μg BPA/kg/day via oral administration to the pregnant female on GD 11 -17 [33]. In this study, serotonin, serotonin transporter, and serum testosterone were not altered [33].…”

Section: Effects On Neurotransmitters and Their Receptors Neuroendocmentioning

confidence: 51%

“…Esrl and Esr2 mRNA expression were also increased in the dorsal raphe nucleus (DRN) of male ICR (CD-1) mice prenatally exposed to 2 μg BPA/kg/day via oral administration to the pregnant female on GD 11 -17 [33]. In this study, serotonin, serotonin transporter, and serum testosterone were not altered [33]. BPA induced changes in somatostatin receptors in the brains of offspring born to Sprague-Dawley rats that received an oral dose of 400 μg BPA/kg/day during pregnancy and lactation.…”

Section: Effects On Neurotransmitters and Their Receptors Neuroendocmentioning

confidence: 99%

See 1 more Smart Citation

In vivo effects of bisphenol A in laboratory rodent studies

Richter

Birnbaum

Farabollini

et al. 2007

Reproductive Toxicology

1,030

733

View full text Add to dashboard Cite

Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/kg/day, in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10 to 1,000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low-dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long-lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.

show abstract

Section: Effects On Neurotransmitters and Their Receptors Neuroendocmentioning

confidence: 51%

Section: Effects On Neurotransmitters and Their Receptors Neuroendocmentioning

confidence: 99%

In vivo effects of bisphenol A in laboratory rodent studies

Richter

Birnbaum

Farabollini

et al. 2007

Reproductive Toxicology

1,030

733

View full text Add to dashboard Cite

show abstract

“…There are controversies about the effects of BPA on the ERs expression. Kawai et al [31] found an increased expression of both ERa and ERb at 5 and 13 weeks postnatal in the dorsal raphe nucleus of the mice exposed prenatally to BPA at 2 mg/kg/d; however, the difference disappeared by 9 weeks postnatal. Khurana et al [31] reported that prenatal treatment with 100 mg/kg/d of BPA increased the expression of ERa and ERb in the anterior pituitary of male rats, but not females, whereas the hypothalamic ERs were less responsive to BPA [32].…”

Section: Discussionmentioning

confidence: 97%

Perinatal exposure to bisphenol‐A changes N‐methyl‐D‐aspartate receptor expression in the hippocampus of male rat offspring

Wang

Zhang

et al. 2009

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Bisphenol-A (BPA) is one of the most common environmental endocrine disrupters with mixed estrogen agonist/antagonist properties. The toxicity of BPA has been extensively evaluated in a variety of tests in rodents, including developmental and reproductive toxicity, and carcinogenicity. The objective of the present study is to evaluate whether or not perinatal maternal exposure to BPA at 0.05, 0.5, 5, 50, and 200 mg/kg/d affects N-methyl-D-aspartate (NMDA) receptor (NMDAR) subunits NR1, NR2A, 2B, estrogen receptor beta (ERbeta), and aromatase cytochrome P450 (P450arom) protein expressions of hippocampus in male rat offspring during postnatal development. Western-blotting analyses showed that perinatal exposure to BPA significantly affected the expression of NMDAR subunits. At the lower doses of 0.05 to 50 mg/kg/d, BPA concentration dependently inhibited the expression of NMDAR subunits. However, at the higher dose (200 mg/kg/d), the effects of BPA on these subunits were different, with a stronger inhibition of NR1 expression and a slighter inhibition of NR2A, 2B expression when compared with those at the lower dosage of BPA. In addition, perinatal exposure to BPA inhibited the expression of ERbeta protein, but increased P450arom protein expression in a concentration-dependent manner, especially during the early postnatal period (the first 1-3 postnatal weeks). No significant influence of BPA on P450arom was observed at postnatal week 8. These data suggest that environmental BPA exposure may affect the development of the brain, enhancing the local biosynthesis of estrogen in the brain, inhibiting ERbeta and NMDAR expressions.

show abstract

“…Kawai et al (2007), supported by Japan Sciences Technology and Core Research for Evolutional Science and Technology, evaluated the brain expression of ERa and ERb in male mice exposed in utero to bisphenol A. Pregnant ICR mice were fed bisphenol A in corn oil by micropipette on GD 11-17 at 0 or 0.002 mg/kg bw/Day 9, n 5 18/group).…”

Section: [No Additional Information Was Provided For Statistical Analmentioning

confidence: 99%

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

402

304

View full text Add to dashboard Cite

Changes in estrogen receptors α and β expression in the brain of mice exposed prenatally to bisphenol A

Cited by 53 publications

References 20 publications

In vivo effects of bisphenol A in laboratory rodent studies

In vivo effects of bisphenol A in laboratory rodent studies

Perinatal exposure to bisphenol‐A changes N‐methyl‐D‐aspartate receptor expression in the hippocampus of male rat offspring

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Contact Info

Product

Resources

About