Changes in energy metabolism after induction therapy in patients with severe or moderate ulcerative colitis

Abstract

We investigated the changes in energy expenditure during induction therapy in patients with severe or moderate ulcerative colitis. Thirteen patients (10 men, 3 women; mean age, 36.5 years) with ulcerative colitis admitted to the Shiga University Hospital were enrolled in this study. We measured the resting energy expenditure and respiratory quotients of these patients before and after induction therapy with indirect calorimetry. We analyzed the changes of nutritional status and serum inflammatory cytokine levels and also evaluated the relationship between energy metabolism and disease activity by using the Seo index and Lichtiger index. The resting energy expenditure was 26.3 ± 3.8 kcal/kg/day in the active stage and significantly decreased to 23.5 ± 2.4 kcal/kg/day after induction therapy (p<0.01). The resting energy expenditure changed in parallel with the disease activity index and C-reactive protein and inflammatory cytokine levels. The respiratory quotient significantly increased after induction therapy. Thus, moderate to severe ulcerative colitis patients had a hyper-metabolic status, and the energy metabolism of these patients significantly changed after induction therapy. Therefore, we recommend that nutritional management with 30–34 kcal/kg/day (calculated as measured resting energy expenditure × activity factor, 1.3) may be optimal for hospitalized ulcerative colitis patients.

Sarcopenia is a predictive factor for intestinal resection in admitted patients with Crohn’s disease

“…A total 72 IBD patients had undergone abdominal computed tomography (CT) two weeks before or after the admission; they had also been assessed by the NST for their nutritional status and resting energy expenditure (REE) using indirect calorimetry within one week after admission. The REE and respiratory quotient (RQ) were measured via a computed open-circuit IC (AE-300S, Minato Medical Science Corporation, Osaka, Japan), as previously described [ 5 , 6 , 27 – 30 ]. The basal energy expenditure (BEE) was calculated using the Harris-Benedict equation [ 31 ].…”

Energy metabolism and nutritional status in hospitalized patients with lung cancer

“…The mREE (kcal/kg/day), respiratory quotient (RQ), carbohydrate oxidation, and fat oxidation were measured via computed open-circuit indirect calorimetry (AE-300S, Minato Medical Science Co., Osaka, Japan). ( 21 , 27 – 31 ) Indirect calorimetry was performed in the hospital room after 8 h of fasting. Period flow and gas calibration were performed prior to all measurements.…”

ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease

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