Changes in Dermal Histomorphology Following Surgical Weight Loss Versus Diet-Induced Weight Loss in the Morbidly Obese Patient

Abstract

Although the differences in histomorphology between the surgical and nonsurgical weight loss groups did not reach statistical significance, the results demonstrated an existence of weight loss-induced histomorphological skin changes that may impact future studies. The study did not demonstrate a relationship between dermal histomorphology and postoperative wound complications, suggesting that aberrant healing in body contouring procedures involves a multifactorial process.

Changes in dermal structure and skin oxidative stress in overweight and obese Japanese males after weight loss: a longitudinal observation study

“…It has been reported that obese people have a poorly organized dermal collagen structure because of the degradation of collagen fibers. These individuals possess a degraded and diffused collagen matrix compared with individuals with a normal body weight . Some studies have found higher skin oxidative stress due to the accumulation of subcutaneous fat and collagenolytic enzymes in the skin, which influenced the degradation of collagen fibers .…”

“…These individuals possess a degraded and diffused collagen matrix compared with individuals with a normal body weight. [1][2][3] Some studies have found higher skin oxidative stress due to the accumulation of subcutaneous fat and collagenolytic enzymes in the skin, which influenced the degradation of collagen fibers. [4][5][6] Moreover, our previous study clarified that the degree of obesity was higher; dermal echogenicity was lower; and dermal thickness was higher in the abdomen, thighs, and upper arms of obese males compared with normal body-weight males.…”

Structural changes in dermal collagen and oxidative stress levels in the skin of Japanese overweight males

“…It has been reported that obese people have poorly organized dermal collagen structure because of the degradation of collagen fibres, and these dermal changes were irreversible. Furthermore, these individuals possess a degraded and diffused collagen matrix compared with normal, healthy controls [1][2][3]. It has also been shown that this dermal condition does not change even after weight loss by bariatric surgery [1].…”

Quality of life and scar evolution after negative pressure or conventional therapy for wound dehiscence following post‐bariatric abdominoplasty

“…(7) Post-bariatric patients often present with nutritional deficiencies, particularly in the first postoperative year, which are able to negatively influence the wound-healing process. (15)(16)(17)(18) A recent study reported that pre-treatment protein supplementation was a simple intervention that could significantly decrease wound-healing complications after abdominoplasty in post-bariatric patients with massive weight loss. (19) In this study, 18% (n = 38) of the entire population of 203 patients admitted in our unit for scheduled post-bariatric abdominoplasty over a 9-year period had a diagnosis of postoperative wound dehiscence.…”