Changes in dermal structure and skin oxidative stress in overweight and obese Japanese males after weight loss: a longitudinal observation study

Matsumoto, Masaru; Ogai, Kazuhiro; Aoki, Miku; Urai, Tamae; Yokogawa, Masami; Tawara, Mari; Kobayashi, Masayuki; Minematsu, Takeo; Sanada, Hiromi; Sugama, Junko

doi:10.1111/srt.12443

Cited by 5 publications

(6 citation statements)

References 22 publications

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“…Our data contrasts with a Japanese study in which skin taken from women undergoing breast reconstruction showed a shift to greater epidermal thickness in the obese when compared to non-obese subjects, but the variation was very large [24]. In another study in obese subjects in which dermal structure in abdominal skin was visualized as echogenicity using ultrasound scanners, weight reduction decreased dermal thickness in about half of the subjects [25]. A previous study also observed no increase in skin thickness in obese subjects weighing up to 200 kg.…”

Section: Discussioncontrasting

confidence: 99%

Obesity and Race Alter Gene Expression in Skin

Walker

Garcet

Alemán

et al. 2020

Preprint

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Obesity is accompanied by dysfunction of many organs, but effects on the skin have received little attention. We studied differences in epithelial thickness by histology and gene expression by Affymetrix gene arrays and PCR in the skin of 10 obese (BMI 35-50) and 10 normal weight (BMI 18.5-26.9) postmenopausal women paired by age and race. Epidermal thickness did not differ with obesity but the expression of genes encoding proteins associated with skin blood supply and wound healing were altered. In the obese, many gene expression pathways were broadly downregulated and subdermal fat showed pronounced inflammation. There were no changes in skin microbiota or metabolites. African American subjects differed from Caucasians with a trend to increased epidermal thickening. In obese African Americans, compared to obese Caucasians, we observed altered gene expression that may explain known differences in water content and stress response. African Americans showed markedly lower expression of the gene encoding the cystic fibrosis transmembrane regulator characteristic of the disease cystic fibrosis. The results from this preliminary study may explain the functional changes found in the skin of obese subjects and African Americans.

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Section: Discussioncontrasting

confidence: 99%

Obesity and Race Alter Gene Expression in Skin

Walker

Garcet

Alemán

et al. 2020

Preprint

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“…41 has been reported to reverse some aspects of obesity-linked dermal changes. 44 The present findings extend our understanding of the impact of obesity and overweight on skin properties as assessed via TDC measurements.…”

Section: Discussionsupporting

confidence: 71%

“…Alterations in skin microcirculation of obese persons have also been reported, and obesity has been linked to several skin dermatoses and conditions . Weight loss has been reported to reverse some aspects of obesity‐linked dermal changes . The present findings extend our understanding of the impact of obesity and overweight on skin properties as assessed via TDC measurements.…”

Section: Discussionsupporting

confidence: 66%

Skin tissue dielectric constant in women with high body fat content

Mayrovitz

Forbes

Vemuri

et al. 2019

Skin Research and Technology

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Background Skin tissue dielectric constant (TDC) measurements at a frequency of 300 MHz are used to assess skin properties in many conditions. Impacts of patient obesity on these values are unknown, and its quantitative assessment was the goal of this research. Materials and Methods Women in a weight loss program (N = 32) had TDC measured on forearm, biceps, neck, jowl, and submental regions along with measurements of total body fat (TBF), water (TBW), intracellular water (ICW), and extracellular water (ECW) via multi‐frequency bioimpedance. Group age (mean ± SD) was 40.0 ± 11.6 years (20‐70 years) with body mass index (BMI) of 31.8 ± 6.7 Kg/m2 (23.0‐49.9 Kg/m2). For analysis, subjects were divided into those with BMI < 30 Kg/m2 (subgroup A, n = 16) vs ≥30 Kg/m2 (subgroup B, n = 16). Results Tissue dielectric constant at forearm and biceps decreased significantly (P < .001) with increasing depth from 0.5 to 1.5 to 2.5 mm but TDC values and their inter‐side ratios did not differ between subgroups A and B at any measured site. Although correlations between TBW, ECW, and ICW were significant (P < .001), there was no dependence of TDC values on any of these parameters. Conclusions Previously unknown TDC values for obese persons are provided and based on subgroup analyses suggest that skin TDC values in overweight and obese persons are not confounded by variables such as TBW and TBF. Further, since inter‐side ratios and their SD’s yielded thresholds for forearm and biceps similar to those established for women with normal BMI, use of these clinical inter‐arm TDC ratios now is extended to include a wider BMI range.

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“…In another study on obese (BMI 35-50) and non-obese postmenopausal women between the ages of 40 and 70 years, no differences in relation to the thickness of the epidermis between those groups were found, despite existing differences in gene expression profile (Walker et al, 2020). Furthermore, another study by Matsumoto et al, revealed that weight reduction leads to a decrease in epidermal thickness by about 50% of analysed obese males (Matsumoto et al, 2018). It is also worth mentioning that in some previously published studies, the BMI of analyzed patients is not given.…”

Section: Discussionmentioning

confidence: 93%

Fatty acid profiles in various lipid fractions in the female epidermis. Does the body site and age matter?

et al. 2022

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Background: The epidermis forms the barrier between an organism and its external environment. Although one of the major functional elements of the epidermis is the lipid-enriched extracellular matrix, containing mainly ceramides, cholesterol (CHOL) and free fatty acids, the data are limited regarding the lipid profile in the epidermis. The aim of the study was to determine the whole profile of fatty acids (FAs) in the epidermis and to examine any dependence according to the age of the subject and the site on the epidermis. Materials and methods: Epidermis extracts obtained from 10 adults and 6 children were analyzed by gas chromatography-mass spectrometry. Results: In total, 74 FAs in the human epidermis were identified. We observed the highest amounts of neutral lipids (including CHOL) compared to other lipid fractions in the epidermis, regardless of age. However, we detected an age-dependent content of the major lipid fractions, where the main difference was in the levels of polyunsaturated fatty acids. There were also differences in the lipid profile between various sites of the body, e.g. samples from the breast and abdomen were enriched with very long-chain fatty acids compared to the limb. Conclusion: Our research provides novel data concerning the lipid profile in the epidermis, gives further insight into skin biology and proves that the epidermis is a highly dynamic structure.

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Changes in dermal structure and skin oxidative stress in overweight and obese Japanese males after weight loss: a longitudinal observation study

Abstract: The dermal structure in the thighs of overweight young individuals can be improved to the level of the structure in those of normal body weight individuals following weight loss.

Cited by 5 publications

References 22 publications

Obesity and Race Alter Gene Expression in Skin

Obesity and Race Alter Gene Expression in Skin

Skin tissue dielectric constant in women with high body fat content

Fatty acid profiles in various lipid fractions in the female epidermis. Does the body site and age matter?

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