Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in healthy bitches and those with pyometra

Dąbrowski, Roman; Wawron, W.; Kostro, K.

doi:10.1016/j.theriogenology.2006.07.019

Cited by 88 publications

(89 citation statements)

References 17 publications

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“…The groups presented a significant difference (p < 0.01) in the results only on D18 ( Figure 5). Although not in relation to canine ehrlichiosis, haptoglobin levels had already been assessed in many studies in relation to infectious diseases (KOGIKA et al, 2003;DABROWSKI et al, 2007;MATIJATKO et al, 2007), inflammatory diseases (BAYRAMLI; ULUTAS, 2008;LOWRIE et al, 2009) and neoplasia (MISCHKE et al, 2007). Under all the conditions described, haptoglobin levels were found to be higher than under normal conditions.…”

Section: Resultsmentioning

confidence: 99%

Experimental Ehrlichia canis infection changes acute-phase proteins

Munhoz

Faria

Vargas-Hérnandez

et al. 2012

Rev. Bras. Parasitol. Vet.

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Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease.Keywords: Ehrlichia canis, experimental infection, acute-phase proteins, dogs. ResumoO diagnóstico precoce da erliquiose canina favorece a pronta instituição do tratamento e melhora o prognóstico do animal, pois se trata de uma doença de alta mortalidade em cães. Estudos têm apontado que a determinação da concentração de proteínas de fase aguda (PFA) pode contribuir para detecção precoce de doenças e auxiliar na predição do prognóstico. O presente estudo objetivou avaliar o perfil de proteínas de fase aguda (PFA) em cães experimentalmente infectados com Ehrlichia canis, no início da infecção e após o tratamento. Além disso, se seria possível associá-las com as alterações clínico-laboratoriais durante o curso da doença. Os resultados obtidos evidenciaram que todas as PFA estudadas alteraram suas concentrações em D3 (dia 3), comparadas ao D0, atingindo concentrações máximas em D18, com exceção da ceruloplasmina e da glicoproteína ácida, cujos picos foram observados em D6 e D12, respectivamente. Concluímos que a avaliação das concentrações de PFA poderiam contribuir para o diagnóstico precoce da erliquiose canina, principalmente com relação à ceruloplasmina e glicoproteína ácida, pois seus aumentos foram anteriores ao aparecimento dos sinais clínicos e das alterações laboratoriais da doença.Palavras-chave: Ehrlichia canis, infecção experimental, proteínas de fase aguda, cães.

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Section: Resultsmentioning

confidence: 99%

Experimental Ehrlichia canis infection changes acute-phase proteins

Munhoz

Faria

Vargas-Hérnandez

et al. 2012

Rev. Bras. Parasitol. Vet.

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“…C‐reactive protein is a positive type II acute phase protein expressed in the liver69 in response to infection, inflammation, or cancer,70 and the serum CRP concentration is a nonspecific marker of inflammation 71, 72, 73, 74, 75, 76, 77, 78, 79, 80. Quantification of canine CRP in serum can be done using several assay formats,81, 82, 83, 84, 85, 86, 87, 88 all of which have a reference interval of approximately 0–8 mg/L.…”

Section: Biomarkers In Chronic Inflammatory Enteropathies Of Dogsmentioning

confidence: 99%

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Heilmann

Steiner

2018

Veterinary Internal Medicne

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Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food‐responsive, antibiotic‐responsive, or immunosuppressant‐responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein‐losing enteropathy. Disease‐independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment. Histopathologic and routine clinicopathologic findings are usually not able to distinguish the subgroups of CIE. Treatment trials are often lengthy and further diagnostic tests are usually at least minimally invasive. Biomarkers that can aid in defining the presence of disease, site of origin, severity of the disease process, response to treatment, or a combination of these would be clinically useful in dogs with CIE. This article summarizes the following biomarkers that have been evaluated in dogs with CIE during the last decade, and critically evaluates their potential clinical utility in dogs with CIE: functional biomarkers (cobalamin, methylmalonic acid, folate, α1‐proteinase inhibitor, immunoglobulin A), biochemical biomarkers (C‐reactive protein, perinuclear anti‐neutrophilic cytoplasmic antibodies, 3‐bromotyrosine, N‐methylhistamine, calprotectin, S100A12, soluble receptor of advanced glycation end products, cytokines and chemokines, alkaline phosphatase), microbiomic biomarkers (microbiome changes, dysbiosis index), metabolomic biomarkers (serum metabolome), genetic biomarkers (genomic markers, gene expression changes), and cellular biomarkers (regulatory T cells). In addition, important performance criteria of diagnostic tests are briefly reviewed.

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“…In pyometra (Figure 3), CRP, SAA and haptoglobin were valid indicators of the infl ammatory state of the uterus and systemic infl ammation mainly caused by E. coli endotoxins, making it possible to differentiate between open and closed cervix infections and to evaluate the severity of the infl ammatory process especially with post-surgical complications [10,29,30]. A recent study demonstrated the clinical value of SAA determination in bitches with signifi cant differences between septic (130.8 mg/L) and non-septic pyometra (88.5 mg/L) while CRP values did not show signifi cant differences between both groups.…”

Section: Dogsmentioning

confidence: 99%

“…Additionally, CRP concentration in combination with Figure 3. Overview of C-reactive protein, haptoglobin and serum amyloid A concentrations in pyometra in bitches [3,10,29,30,32,34] the percentage of band neutrophils was useful to differentiate between pyometra and cystic endometrial hyperplasia. CRP showed 97.7% sensitivity and 75% specifi city in predicting the presence of pyometra [34].…”

Section: Dogsmentioning

confidence: 99%

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Schmidt

Eckersall

2015

Acta Veterinaria

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During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

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Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in healthy bitches and those with pyometra

Cited by 88 publications

References 17 publications

Experimental Ehrlichia canis infection changes acute-phase proteins

Experimental Ehrlichia canis infection changes acute-phase proteins

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

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