Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy

Faramarzi, Azita; Feizi, Sepehr; Najdi, Danial; Ghiasian, Leila; Karimian, Farid

doi:10.1097/ico.0000000000000684

Cited by 11 publications

(1 citation statement)

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“…[37] However, we recently demonstrated that corneal biomechanical parameters were significantly increased after DSAEK, attaining the values measured in normal eyes. [38] Improvement in the corneal biomechanics of the host-graft complex after DSAEK could be more prominent when a thicker graft is transplanted, which would explain the significant association between graft thickness and postoperative IOP observed in the current study.…”

Section: Discussionmentioning

confidence: 83%

Effect of donor graft thickness on clinical outcomes after descemet stripping automated endothelial keratoplasty

Feizi

Javadi

2019

J Ophthalmic Vis Res

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Purpose: To evaluate the effects of donor graft thickness on postoperative best spectacle-corrected visual acuity (BSCVA), refractive outcomes, endothelial cell density (ECD) and function, intraocular pressure (IOP), and postoperative complications after Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This retrospective, interventional case series enrolled 77 eyes of 64 patients who underwent DSAEK with or without simultaneous cataract surgery. Clinical outcomes, including BSCVA, refraction, keratometric astigmatism, IOP, and ECD were assessed at the final follow-up examination. Univariate analyses were used to investigate the effects of postoperative donor graft thickness on clinical outcomes and complications. Results: The mean patient age was 62.3 ± 15.6 years, and the patients were followed for 26.2 ± 20.9 months postoperatively. The mean postoperative central graft thickness was 102.4 ± 31.6 μm. In the univariate analysis, postoperative central graft thickness was significantly associated with postoperative IOP ( P = 0.005), central recipient thickness ( P = 0.002), and ECD ( P = 0.016). No significant association was found for central graft thickness with postoperative BSCVA ( P = 0.70), spherical equivalent refraction ( P = 0.33), keratometric astigmatism ( P = 0.27), graft detachment ( P = 0.16), graft decentration ( P = 0.17), high IOP ( P = 0.53), or endothelial rejection ( P = 0.88). Conclusion: This study failed to demonstrate any significant correlation between graft thickness and BSCVA. Attempting to minimize graft thickness might not have the desired outcome regarding endothelial cell density and function. Increased graft thickness could negatively impact the accuracy of IOP measurements after DSAEK.

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Section: Discussionmentioning

confidence: 83%