Changes in Collagen Types During the Healing of Rabbit Tooth Extraction Wounds

Kurita, Keisuke; Hashimoto, Yoko; Takei, T.; Kawai, Tetsushi; Hayakawa, Taro

doi:10.1177/00220345850640010501

Cited by 43 publications

(24 citation statements)

References 20 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the results of Eisenmenger et al [7] it has additionally been shown that collagen III appears 2-3 days after wound infliction and collagen V after approximately 3 days [5]. Therefore, our results support the findings of other authors [7,9,13,14,17] who in general reported a delayed appearance of collagen I during wound healing when compared to other interstitial collagen subtypes.…”

Section: Discussionsupporting

confidence: 92%

“…Kurita and co-workers [13] showed -in contrast to Vialle-Presles et al [19] -an increased synthesis of collagen V in the early phases of wound healing after tooth extraction in rabbits when compared to collagen type I. After 5 days they observed a decrease in the collagen V/I-ratio indicating an increased collagen I production at this point of time in comparison to collagen V. Kurkinen et al [14] found a sequential appearance of fibronectin, procollagen III, collagen III and collagen I between 2 and 7 days after implantation of cell-stics in mouse skin.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical localization of collagen types I and VI in human skin wounds

Betz

Nerlich²,

Wilske

et al. 1993

Int J Leg Med

View full text Add to dashboard Cite

Summary.A total of 74 human skin wounds were investigated and collagen types I and VI were localized in the wound area by immunohistochemistry. Collagen type I appeared in the form of ramifying string-like structures after approximately 5-6 days, but positive reactions in the form of a spot-like staining around isolated fibroblasts also occurred in a skin wound aged 4 days. Collagen VI was detectable after a post-infliction interval of at least 3 days showing a strongly positive reacting network associated with fibroblasts in the wound area. Both collagens appeared almost constantly after a wound age of 6-7 days and could also be found in wounds aged a few months. Therefore, although a positive reaction for collagen type I in the form of string-like and ramifying structures around wound fibroblasts indicates a wound age of at least 5-6 days, a spot-like positive staining for collagen type I cannot exclude a wound age of at least 4 days. A positive staining for collagen type VI represents a postinfliction time of 3 days or more. The almost constant appearance of these collagen types suggests that negative results in a sufficient number of specimens indicate a wound age of less than 6-7 days, but cannot completely exclude longer post-infliction intervals. Since collagen type I and VI are also found in the granulation/scar tissue of lesions with advanced wound age, the immunohistochemical analysis of these proteins provides no further information for an age determination of older skin wounds.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Immunohistochemical localization of collagen types I and VI in human skin wounds

Betz

Nerlich²,

Wilske

et al. 1993

Int J Leg Med

View full text Add to dashboard Cite

show abstract

“…In our study, socket healing with formation of bone matrix was observed at the end of the third week. These results were similar to those obtained by Kurita et al 15 and allowed for more rapid investigation of implant osseointegration. When the tooth alveolus anatomy is taken into account and a good surgical Yellow arrows indicate the contact area between the implants surface and newly formed bone tissue.…”

Section: Discussionsupporting

confidence: 90%

In-vivo bone response to titanium screw implants anodized in sodium sulfate

Pinheiro

Mourão

Diniz³

et al. 2014

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To evaluate the early bone response to a nanotextured dental implant treated with sodium sulfate (Na 2 SO 4 ), using a rabbit model. METHODS:Twelve animals were randomly divided into group 1 (Control) -machined implants and group 2 (Test) -nanotextured implants. Extra-oral incision was performed to provide access to intended surgical site where the dental implant was inserted immediately after the extraction of the mandibular first premolar. Implant surface characterization was performed by scanning electron microscopy attached to energy dispersive spectroscopy and interferometry. Three weeks after surgery, the animals were induced to death and undecalcified sections of the samples were prepared for histological and histomorphometrical analysis. RESULTS:Surface characterization of the implant demonstrated enhanced surface area of anodized group compared to Control group with 19.2% ± 6.2 versus 1.6 ± 0.7, respectively. Histological evaluation demonstrated new bone formation starting from the buccal and lingual cortical walls on both groups. After three weeks, significant higher bone contact of 27% (p<0.05) was observed to nanotextured compared to machined implants (Control group). CONCLUSION:The anodization with sodium sulfate nanostructures to the implant surface that resulted in faster osseointegration.

show abstract

“…As type III collagen is deposited in granulation tissue before type I collagen 11) , the amount of type III collagen increases in the early stages of wound healing in the skin and skeletal muscle 12,13) . A similar pattern has been reported in tooth extraction sites 9,14) . Kurita et al 9 Another important role of type III collagen is enhancement of platelet aggregation 16,17) .…”

Section: Discussionsupporting

confidence: 87%

“…In the healing of a tooth extraction socket, new bone formation depends on the deposition of hydroxyapatite crystals along the collagen fibers 9) . Type I collagen is the major constituent of interstitial connective tissue and is also found in most other types of connective tissues.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Tooth Extraction Wound Protection Made of Atelocollagen Sponge (TRE-641): A Pilot Study in Dogs

Hirota

Mizuki

Aoki

et al. 2009

J. Hard Tissue Biology.

View full text Add to dashboard Cite

Abstract:To evaluate the efficacy of tooth extraction wound protection made of atelocollagen sponge (TRE-641), we observed healing in tooth extraction sites filled with TRE-641 and those filled with a control material, oxide cellulose. Subjects were 11 beagle dogs, with a total of 22 extraction sites. Both maxillary lateral incisors were carefully removed, and extraction wounds were filled with TRE-641 on one side and with oxidized cellulose sponge as control on the other side. Wound healing was observed, and the animals were sacrificed at 7, 14, and 28 days after surgery. We compared extent of bone formation, hematoma, inflammation, and graft material remaining between the two groups. At 7 days, newly formed bone extending from the floor and wall of the socket bone were seen in the TRE-641. Hematoma and inflammation were observed in the oxide cellulose. At 14 days, a small amount of TRE-641 remained. In the oxide cellulose group, a small amount of hematoma remained. At 28 days, the extraction socket was filled with newly formed bone in both groups. TRE-641 produced acceptable early phase bone healing at the tooth extraction site with no remnant graft material with sufficient bone formation of the tooth extraction wound.

show abstract

Changes in Collagen Types During the Healing of Rabbit Tooth Extraction Wounds

Cited by 43 publications

References 20 publications

Immunohistochemical localization of collagen types I and VI in human skin wounds

Immunohistochemical localization of collagen types I and VI in human skin wounds

In-vivo bone response to titanium screw implants anodized in sodium sulfate

Efficacy of Tooth Extraction Wound Protection Made of Atelocollagen Sponge (TRE-641): A Pilot Study in Dogs

Contact Info

Product

Resources

About