Changes in Clinical Presentation, Management and Outcome in 1348 Patients with Differentiated Thyroid Carcinoma: Experience in a Single Institute in Hong Kong, 1960–2000

Chow, Sin‐Ming; Law, Stephen C.K.; Au, Siu-Kie; Mang, Oscar; Yau, Stephen S.-T.; Yuen, Kam‐Tong; Lau, W.S.

doi:10.1016/s0936-6555(03)00066-9

Cited by 71 publications

(56 citation statements)

References 43 publications

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“…A similar trend has been reported in France where there was an increase in thyroid cancer incidence, mainly due to the papillary type, with an epidemic of microcarcinomas (43% of operated cancers, for the period 1998-2001) (Leenhardt et al, 2004a). This trend has been reported in many other studies (Chow et al, 2003;Colonna et al, 2007;Scheiden et al, 2006;Verkooijen et al, 2003). The improvement in diagnostic tools (image procedures and fineneedle aspiration biopsy) (Colonna et al, 2007;Scheiden et al, 2006) and greater extensiveness and number of thyroidectomies performed, which makes it easier to detect MPTCs (Leenhardt et al, 2004a), has been suspected to be of etiological importance in the observed increase of papillary thyroid cancer.…”

Section: Discussionsupporting

confidence: 86%

An Epidemiological Analysis of Thyroid Cancer in a Spanish Population: Presentation, Incidence and Survival

Rego-Iraeta¹,

Pérez-Méndez²,

García‐Mayor³

2012

Updates in the Understanding and Management of Thyroid Cancer

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Section: Discussionsupporting

confidence: 86%

An Epidemiological Analysis of Thyroid Cancer in a Spanish Population: Presentation, Incidence and Survival

Rego-Iraeta¹,

Pérez-Méndez²,

García‐Mayor³

2012

Updates in the Understanding and Management of Thyroid Cancer

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“…In our hospital, the rate of LR failure has decreased gradually in the recent three decades from 41.7 to 22.9%, and then to 7.4% (Chow et al 2003). This improvement might be related to diagnosis at an earlier stage and a higher rate of bilateral surgery, RAI ablation, and EXT.…”

Section: Introductionmentioning

confidence: 74%

Local and regional control in patients with papillary thyroid carcinoma: specific indications of external radiotherapy and radioactive iodine according to T and N categories in AJCC 6th edition

Chow

Yau²,

Kwan

et al. 2006

Endocr Relat Cancer

130

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To identify indications for external radiotherapy (EXT) and radioactive iodine (RAI) in papillary thyroid carcinoma (PTC), we conducted a retrospective study of local and regional control in 1297 patients diagnosed with PTC in a tertiary referral center. Managed by surgery alone, patients with bilateral thyroidectomy had a lower rate of local relapse compared with lobectomy (PZ0.02). EXT improved locoregional (LR) failure-free survival (FFS) (P!0.001) and survival (PZ0.01) in patients with gross postoperative LR residual disease. EXT also improved local FFS in patients with pathologically confirmed positive resection margins (P!0.001) and reduced local failures in patients with T4 disease (PZ0.002). In patients with lymph nodes (LN) metastasis, more extensive surgery by functional or radical neck dissection resulted in less LN relapse compared with excision alone (P!0.001). EXT improved 10-year LN FFS in patients with N1b disease (PZ0.005) and patients with LN metastasis of size O2 cm (PZ0.02). RAI was effective in improving local control in patients with T2 to T4 diseases and LN control in patients with N0, N1a, and N1b categories. Local or LN relapses were associated with worse survival (P!0.001 and P!0.0001). The survival of patients with PTC could be improved by reducing local or LN relapses. RAI is indicated in patients with T2 to T4 disease. EXT is indicated in patients with gross postoperative disease, positive resection margins or T4 disease, N1b, or a LN size of O2 cm. LN relapse can be reduced by RAI in N0, N1a, and N1b disease.

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“…14 Further subdivision of tumors by size (Յ 5 mm vs. Ͼ 5 mm) was suggested by Kasai and Sakamoto because of the lower frequency of LN metastasis and extrathyroid extension in the subgroup of patients with smaller tumors. 19 Studies in our hospital 21 and in Japan 22 revealed a temporal trend toward decreasing tumor size of PTC. With advances in ultrasonography and fine-needle aspiration biopsies, especially in mass screening programs, PMC can be diagnosed before surgery.…”

mentioning

confidence: 86%

Papillary microcarcinoma of the thyroid—Prognostic significance of lymph node metastasis and multifocality

Chow

Law

Chan

et al. 2003

Cancer

672

479

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Portable electronic devices operate at varying power demand levels. This variability of power demand must be considered explicitly in the design of man‐portable power generation systems for acceptable performance and portability. In this regard, a mathematical programming based design method is proposed. The method transcribes optimal operation of the system at a given power demand into a mathematical program. The power demand specific programs are incorporated into another upper level mathematical program encoding design requirements to form a final two‐stage formulation. The design and operational parameters of the power generation system comprise a solution of the formulation. Unlike designs, based on a nominal power demand, the design guarantees that each power demand and all operational requirements can be satisfied. A detailed study of a microfabricated fuel‐cell based system is performed. The proposed method produces smaller designs with significantly better performances than nominal power demand based approaches. © 2008 American Institute of Chemical Engineers AIChE J, 2008

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Changes in Clinical Presentation, Management and Outcome in 1348 Patients with Differentiated Thyroid Carcinoma: Experience in a Single Institute in Hong Kong, 1960–2000

Cited by 71 publications

References 43 publications

An Epidemiological Analysis of Thyroid Cancer in a Spanish Population: Presentation, Incidence and Survival

An Epidemiological Analysis of Thyroid Cancer in a Spanish Population: Presentation, Incidence and Survival

Local and regional control in patients with papillary thyroid carcinoma: specific indications of external radiotherapy and radioactive iodine according to T and N categories in AJCC 6th edition

Papillary microcarcinoma of the thyroid—Prognostic significance of lymph node metastasis and multifocality

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