Changes in cerebral perfusion after acute head injury: comparison of CT with Tc-99m HM-PAO SPECT.

Abstract

Technetium-99m hexamethylpropyleneamine oxime (Tc-99m HM-PAO) was successfully used with single photon emission computed tomography (SPECT) on fourteen comatose patients who had acute head injuries. The SPECT scans were correlated with computed tomography (CT) scans obtained within 24 hours of the injury. Tc-99m HM-PAO SPECT was shown to have the following advantages: It reflected perfusion changes, was more sensitive than CT in demonstrating more lesions, and demonstrated lesions at an earlier stage than those demonstrated with CT. Different types of lesions, as evidenced by cerebral perfusion changes, have been described and categorized. The lesions that had a favorable prognosis could be separated from those with an unfavorable prognosis on the basis of the findings of Tc-99m HM-PAO SPECT.

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

“…Early landmarks in SPECT research were made by studies that reported findings on patient groups without reference to a control group [Abdul-Dayem et al, 1987;Ryding et al, 1988;Shen et al, 1990;Denays et al, 1990;Holman et al, 1991;Tumeh et al, 1990;Berman et al, 1987]. Other seminal studies used controls without reference to gender or age [Costa et al, 1988;Holman et al, 1991], or they compared patient groups to one another.…”

Imaging of Cerebral Blood Flow in Patients with Severe Traumatic Brain Injury in the Neurointensive Care

“…It was shown that SPECT detected 40% more lesions than shown by CT scans (65). Similar results have been reported by Roper et al (66).…”

Review of Two Years of Experiences with SPECT Among Psychiatric Patients in a Rural Hospital Setting

“…[3][4][5][6][7] However, it should be noted that "MRI sequences," new and complicated techniques for improving neuroimaging quality, may alter this conclusion in the future, although we could find no published studies that have directly compared MRI sequences to SPECT. SPECT scans were ordered only for patients in whom documentation of hypoperfusion and functional deficits might be helpful in clarifying diagnoses and treatment planning.…”