Changes in cellular and molecular components of peripheral blood in patients with generalized aggressive periodontitis

Gaddale, Reetika; Mudda, Jayashree A; Ilangovan, Karthikeyan; Desai, Shrikar R.; Shinde, Harshada; Deshpande, Pavan

doi:10.1111/jicd.12127

Cited by 13 publications

(12 citation statements)

References 61 publications

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“…The previous study of this working group did not show remarkable differences regarding PCT (Ziebolz et al, ). Moreover, CRP and leucocytes were especially found to be increased in periodontitis subjects in previous examinations (Loos, ; Iqbal et al, ; Gaddale et al, ). Furthermore, a study by Anumolu et al .…”

Section: Discussionmentioning

confidence: 67%

“…Another question of the current study was the association of the periodontal disease severity with common blood parameters. Different previous investigations were able to present differences in blood parameters between periodontal healthy and diseased individuals (Fredriksson et al, ; Buhlin et al, ; Loos, ; Gomes‐Filho et al, ; Iqbal et al, ; Gaddale et al, ; Bolla et al, ). In the current study, only PCT showed conspicuous findings that were not confirmed in post‐hoc testing between the subgroups, which might suggest several statistical outliers.…”

Section: Discussionmentioning

confidence: 85%

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High prevalence of periodontitis in blood donors and the possibility of questionnaire‐based screening – results of a cross‐sectional study

Schmalz

Hübscher

Angermann

et al. 2019

Transfusion Medicine

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Background:Periodontitis is an inflammatory disease of high prevalence and, thus, of potential relevance to the management of blood donation. Objectives:The aim of this cross-sectional study was to assess periodontal health and its associations to common blood parameters, as well as questionnaire-based periodontitis screening in blood donors. Methods:Generally healthy blood donors were recruited and underwent oral examination. Thereby, the decayed-, missingand filled-teeth index (DMF-T) and periodontal status, including periodontal probing depth and clinical attachment loss, were assessed. Based on periodontal status, periodontitis severity was classified into no/mild, moderate or severe. Six yes/no questions regarding periodontal complaints and history were asked. Furthermore, common blood parameters were analysed.Results: A total of 148 participants (mean age 53·33 years) were included. The DMF-T was 15·28 ± 6·44. Nearly three quarters of participants suffered from a periodontitis (moderate 59·5% and severe 14·8%, total periodontitis 74·3%). Periodontitis severity was associated with the history of dental visits caused by periodontal complaints (P < 0·01) and previous periodontal therapy (P < 0·01). Only procalcitonin was initially found to be associated with blood periodontitis severity (P = 0·02). This observation was not confirmed by post-hoc testing between subgroups (P i > 0·2). No further association between periodontitis severity and blood parameters was found (P i > 0·05). bacteria in peripheral blood are required in order to determine the relevance of this result for the safety of blood components.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 85%

High prevalence of periodontitis in blood donors and the possibility of questionnaire‐based screening – results of a cross‐sectional study

Schmalz

Hübscher

Angermann

et al. 2019

Transfusion Medicine

View full text Add to dashboard Cite

show abstract

“…Similar study in humans would not be ideal owing to the variability of samples, which could put the results into question. In addition, blood count is an extremely reliable test and has been used in several medical evaluations and scientific studies [13,18,19]. For those reasons, we found it prudent to use blood count in rats to confirm the hypothesis that infection of endodontic origin may influence systemic health.…”

Section: Discussionmentioning

confidence: 91%

“…The blood count is a highly reliable test and has been used for blood evaluation in several studies [13,18,19]. It is possible to evaluate several blood parameters such as the levels of erythrocytes, leukocytes, neutrophils, and lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Endodontic infections increase leukocyte and lymphocyte levels in the blood

et al. 2017

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“…However, other studies (Pejcic et al, 2011;Gaddale et al, 2014) have confirmed an increased number of WBCs and neutrophils in the peripheral blood of patients with moderate to severe periodontitis, with a positive correlation between disease severity and number of WBCs in the blood.…”

Section: Discussionmentioning

confidence: 93%

Role of Cytokines and Transcription Factors in Periodontitis: A Review of Cellular and Molecular Mechanisms

Leite¹,

Carneiro²,

Nunes

et al. 2015

American Journal of Immunology

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Periodontal Diseases (PD) are characterized by pathological manifestation of host immune response to bacterial infection at the tooth/gingival interface. Evidences points periodontitis as a risk factor for pathological systemic conditions, such as, cardiovascular diseases and diabetes. The identification of host factors that determine their susceptibility to immune subversion can provide useful information in the pathogenesis of periodontitis. Protective acute inflammatory response fails to remove inflammatory cells, especially neutrophils, evolving to chronic, destructive and pathological lesions. T and B cells actively participate in pathogenesis of the disease. CD4+ naive T cells are activated by antigenic stimulation and differentiate into subpopulations of distinct effector cells, characterized by its specific cytokine production profiles and functions. In periodontal infection, activated Th17 and regulatory T lymphocytes (Tregs) play antagonistic roles as effector and suppressor cells, respectively. In presence of Tregs, there is a decrease in the levels of pro-inflammatory cytokines, such as, Interferon gamma (IFN-γ), Interleukin (IL) -17, Tumor Necrosis Factor (TNF) and IL-1 β, at sites of disease. Absence of Tregs may cause a variety of disorders, such as, periodontitis. The RANKL/RANK system and Osteoprotegerin (OPG) are modulators of bone resorption in periodontitis. The balance between periodontal bone resorption by osteoclasts and bone formation by osteoblasts controls bone mass. RANKL induces osteoclast differentiation and maturation and OPG inhibits RANK/RANKL interaction and prevents bone resorption. RANKL mRNA and the RANKL/OPG mRNA ratio were enhanced in chronic periodontitis. Furthermore, the role of NF-kB, FoxP3 and T-bet transcription factors were explored. Therapies for periodontitis involving cellular and molecular biology are not specific and have many side effects. Current therapies to successfully control the PD reduces clinical signs of inflammation at local sites of the disease; however, new treatments for periodontitis should address the contribution of immune cells in bone resorption, particularly in the natural course of the disease, considering its periods of remission and progression.

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Changes in cellular and molecular components of peripheral blood in patients with generalized aggressive periodontitis

Cited by 13 publications

References 61 publications

High prevalence of periodontitis in blood donors and the possibility of questionnaire‐based screening – results of a cross‐sectional study

High prevalence of periodontitis in blood donors and the possibility of questionnaire‐based screening – results of a cross‐sectional study

Endodontic infections increase leukocyte and lymphocyte levels in the blood

Role of Cytokines and Transcription Factors in Periodontitis: A Review of Cellular and Molecular Mechanisms

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