Changes in Cell Volume and in Concentration of Hemoglobin and of Several Inorganic Constituents of the Blood of Calves During Early Postnatal Development

Wise, George; Caldwell, M. J.; Parrish, D.B.; Flipse, R.J.; Hughes, J. S.

doi:10.3168/jds.s0022-0302(47)92427-2

Cited by 42 publications

(17 citation statements)

References 20 publications

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“…Therefore, neither the changes in age nor decreases in PMg concentration do affect the PNa and PK concentrations. The changes in ENa (increase, P < 0.05) and EK (decrease, P < 0.05) concentrations with age were also similar to previous observations (WISE et al, 1948;RASMUSEN et al, 1974). Changes in EK concentrations with age have been associated with the activity of L antigen found in the erythrocyte membrane which controls the active K transport into the erythrocytes (ELLORY and TUCKER, 1969;.…”

Section: Discussionsupporting

confidence: 87%

Changes in Concentrations of Certain Plasma and Erythrocyte Minerals Associated with Hypomagnesaemia in Young Calves

Mulei

Daniel

1989

Journal of Veterinary Medicine Series A

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Summary Hypomagnesaemia was induced in young calves 1–2 weeks old by feeding them with a diet composed of skimmed milk and barley straw to which urea, potassium chloride and soya‐bean oil were added. Blood samples were collected from each calf once a week from the jugular vein until there was a significantly lower (P < 0.01) plasma magnesium (PMg) concentration in the experimental compared to the control calves receiving MgO instead of KCl. In addition to PMg, the blood samples were analysed for plasma sodium, potassium, calcium, inorganic phosphate and erythrocyte concentrations of magnesium, sodium and potassium and red blood cell counts. The erythrocyte magnesium (EMg) concentration decreased significantly (P < 0.01) in both groups. The decrease was, however, greater (P < 0.05) in the magnesium deficient group than in the control group. Erythrocyte sodium (ENa) concentration increased and erythrocyte potassium (EK) concentration decreased in both groups, and the changes did not differ significantly between the two groups. Plasma concentrations of sodium (PNa) and potassium (PK) and red blood cell counts did not change significantly in either group. Significant (P < 0.05) decreases in plasma calcium and inorganic phosphate concentrations occurred in the magnesium deficient group only. Zusammenfassung Veränderungen von Mineralstoff‐Konzentrationen im Plasma und in den Erythrozyten bei der Hypomagnesämie junger Kälber Bei 1–2 Wochen alten Kälbern wurde durch Verfütterung von Magermilch und Gerstenstroh mit Harnstoff‐Kaliumchlorid‐ und Sojaöl‐Zusatz eine Hypomagnesämie induziert. Dabei wurde einmal wöchentlich bei jedem Kalb eine Blutprobe aus der Vena jugularis entnommen, bis sich ein im Vergleich zu Kontrollkälbern, die anstatt KCl MgO erhielten, ein signifikant niedrigerer (p < 0,01) Plasma‐Magnesium‐(PMg)‐Spiegel ergab. Neben dem PMg wurden der Plasma‐Natrium‐, ‐Kalium‐, ‐Calcium‐ und ‐Phosphat‐Spiegel sowie die Konzentrationen von Magnesium, Natrium und Kalium in den Erythrozyten bestimmt. Die Zahl der Erythrozyten wurde ebenfalls ermittelt. Die Magnesium‐Konzentration in den Erythrozyten (EMg) nahm bei beiden Gruppen signifikant (p < 0,01) ab. Diese Abnahme war jedoch bei der Magnesium‐Mangelgruppe größer. Die Natrium‐Konzentration in den Erythrozyten (ENa) erhöhte sich, und die Kalium‐Konzentration in den Erythrozyten (EK) erniedrigte sich in beiden Gruppen. Dabei ergaben sich keine signifikanten Gruppenunterschiede. Die Plasma‐Natrium‐(PNa)‐ und Plasma‐Kalium‐(PK)‐Konzentrationen sowie die Zahl der Erythrozyten veränderten sich in keiner der Gruppen signifikant. Eine signifikante (p < 0,05) Abnahme der Plasma‐Calcium‐ und ‐Phosphat‐Konzentration ergab sich bei der Magnesium‐Mangelgruppe.

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Section: Discussionsupporting

confidence: 87%

Changes in Concentrations of Certain Plasma and Erythrocyte Minerals Associated with Hypomagnesaemia in Young Calves

Mulei

Daniel

1989

Journal of Veterinary Medicine Series A

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“…As cogitações sobre as possíveis causas das diminuições dos componentes do eritrograma observadas no período neonatal estariam relacionadas provavelmente ao efeito hemodiluidor determinado pelas proteínas absorvidas do colostro que ganhariam o sangue circulante (Adams et al 1992, Benesi 1992, Jain 1993) e à intensa metabolização dos eritrócitos fetais não compensada por adequada produção e renovação destas células, caracterizando a chamada "anemia ϐisiológica" (Wise 1947, Tennant et al 1974. Contrariando está última hipótese, Birgel (1972) não encontrou evidências bioquímicas de possível crise hemolítica, reforçando-se as cogitações de que além do efeito hemodiluidor do colostro, haveria uma menor resposta da medula do neonato, devido ao aumento dos níveis sangüí-neos de oxigênio no sangue em relação aos do período fetal, fatos que favoreceriam a diminuição dos componentes do eritrograma no sangue (Adams et al 1992, Jain 1993.…”

Section: Discussionunclassified

Eritrograma de bezerras sadias, da raça Holandesa, no primeiro mês de vida

et al. 2012

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Com a finalidade de estabelecer valores de referência e de avaliar a influência do fator etário sobre o eritrograma de bezerras sadias, da raça Holandesa, utilizaram-se amostras de sangue de 300 animais, distribuídos por 15 grupos experimentais, de acordo com a idade, no primeiro mês de vida. As variações dos valores médios obtidos para os componentes do eritrograma foram as seguintes: número de hemácias (x10(6)/mm³) = 6,68-7,60, volume globular (%) = 29,80-33,35, taxa de hemoglobina (g/dl) = 9,00-10,43, volume corpuscular médio (fl) = 38,93 47,68, hemoglobina corpuscular média (pg) = 11,75-14,69, concentração de hemoglobina corpuscular média (%) = 29,53-31,63% e número de reticulócitos (x10³/mm³) = 0,00-11,86. A influência do fator etário provou-se significativa para o volume corpuscular médio, hemoglobina corpuscular média e número de reticulócitos.

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“…Caldwell, Parrish, Flipse & Hughes (1947) suggested that high potassium content may be a feature of foetal erythrocytes in the ox, and this has been found to apply also in the sheep (Hailman & Karvonen, 1949;Widdas, 1954 b).…”

Section: Post-natal Changementioning

confidence: 94%

Hexose permeability of foetal erythrocytes

Widdas¹

1955

The Journal of Physiology

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Although the permeability properties of erythrocytes from various species have been the subject of extensive investigations during the present century, few studies have been made on the erythrocytes from foetal blood. Widdas (1951) reported that the haemolysis of foetal sheep erythrocytes in hypotonic saline was markedly slower than that of adult sheep erythrocytes. A similar result for human foetal erythrocytes has been reported by Sj6lin (1954) who also studied the mechanical and osmotic resistance (fragility) changes in foetal and neonatal blood.That there might be a difference in permeability to sugars seemed possible from the observation by Hitchcock (1949), confirmed in this Department by Dobbing & Long (unpublished observations), that the sugars in the blood of the foetal sheep were approximately evenly distributed between cells and plasma, whereas the maternal blood sugar was all in the plasma. A study of the distribution of sugars in foetal bloods of various species has recently been reported by Goodwin (1954).The distribution of sugar between cells and plasma gives no evidence as to the nature of the permeability, and the present investigations were undertaken to see if the process of penetration was a simple diffusion or a facilitated transfer such as is postulated to account for glucose penetration into the adult human erythrocyte (LeFevre, 1948;Widdas, 1954a).A preliminary account of the results was given to the XIX International Physiological Congress (Widdas, 1953a). METHODThe apparatus used (Orskov type) was as described (Widdas, 1953b) and the experimental technique and method of analysing the results followed that used for studies on the hexose permeability of human erythrocytes (Widdas, 1954a).The method of collecting foetal blood varied in accordance with the facilities available. In the laboratory, foetuses were delivered by caesarean section under anaesthesia (spinal anaesthesia in the case of the sheep, Nembutal in the case of guinea-pig,'rabbit and cat), and blood obtained from

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Changes in Cell Volume and in Concentration of Hemoglobin and of Several Inorganic Constituents of the Blood of Calves During Early Postnatal Development

Cited by 42 publications

References 20 publications

Changes in Concentrations of Certain Plasma and Erythrocyte Minerals Associated with Hypomagnesaemia in Young Calves

Changes in Concentrations of Certain Plasma and Erythrocyte Minerals Associated with Hypomagnesaemia in Young Calves

Eritrograma de bezerras sadias, da raça Holandesa, no primeiro mês de vida

Hexose permeability of foetal erythrocytes

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