Changes in calciotropic hormones and biochemical markers of bone metabolism in patients with human immunodeficiency virus infection

Teichmann, J.; Stéphan, E.; Discher, Thomas; Lange, U.; Federlin, K.; Stracke, H.; Friese, Georg; Lohmeyer, Jürgen; Bretzel, Reinhard G.

doi:10.1053/meta.2000.8609

Cited by 56 publications

(49 citation statements)

References 21 publications

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“…30,[34][35][36] However, this is thought to be a result of the down-regulation of calcitropic hormones (parathyroid hormone (PTH)) and 1,25 dihydroxychole-calciferal. Certainly calcitropin is known to suppress T-cell activity.…”

Section: Reduced Bmd May Increase the Risk Of Fragility Fracture In Hmentioning

confidence: 99%

Fracture healing in HIV-positive populations

Richardson

Hill

Johnston

et al. 2008

The Journal of Bone and Joint Surgery. British volume

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Highly active anti-retroviral therapy has transformed HIV into a chronic disease with a long-term asymptomatic phase. As a result, emphasis is shifting to other effects of the virus, aside from immunosuppression and mortality. We have reviewed the current evidence for an association between HIV infection and poor fracture healing. The increased prevalence of osteoporosis and fragility fractures in HIV patients is well recognised. The suggestion that this may be purely as a result of highly active anti-retroviral therapy has been largely rejected. Apart from directly impeding cellular function in bone remodelling, HIV infection is known to cause derangement in the levels of those cytokines involved in fracture healing (particularly tumour necrosis factor-alpha) and appears to impair the blood supply of bone. Many other factors complicate this issue, including a reduced body mass index, suboptimal nutrition, the effects of anti-retroviral drugs and the avoidance of operative intervention because of high rates of wound infection. However, there are sound molecular and biochemical hypotheses for a direct relationship between HIV infection and impaired fracture healing, and the rewards for further knowledge in this area are extensive in terms of optimised fracture management, reduced patient morbidity and educated resource allocation. Further investigation in this area is overdue.

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Section: Reduced Bmd May Increase the Risk Of Fragility Fracture In Hmentioning

confidence: 99%

Fracture healing in HIV-positive populations

Richardson

Hill

Johnston

et al. 2008

The Journal of Bone and Joint Surgery. British volume

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“…128,129 Thereafter, several observational studies have shown significant association between higher levels of vitamin D and rates of immune recovery. [130][131][132] Studies have also been conducted to investigate the association of vitamin D and clinical outcomes. Among 884 HIV-infected pregnant women in Tanzania who were followed for a median of 70 months, baseline 25-OHD less than 32 ng/mL was shown to be independently associated with progression to more advanced HIV stage and that women with 25-OHD in the highest quintile had a 42% lower risk of all-cause mortality than women with levels in the lowest quintile.…”

Section: Hiv Disease Progressionmentioning

confidence: 99%

Vitamin D and Calcium Abnormalities in the HIV-Infected Population

Escota

Cross

Powderly

2014

Endocrinology and Metabolism Clinics of North America

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“…Of the remaining (43 papers), 30 articles reported original data with the pre-specified 25OHD cut-off values and were included in the review (Table 1). 6,[8][9][10]60 One study describing the prevalence of vitamin D deficiency in a subgroup of 21 patients with hypocalcemia and ten articles reporting 25OHD status with different cut-off levels were considered only to retrieve information about predictors of vitamin D status, 7,[48][49][50][51][52][53][54][55][56][57] and two duplicate publications were reviewed for additional data not presented in the original study. 42,58,59 Studies' characteristics…”

Section: Literature Searchmentioning

confidence: 99%

“…27,31,41 Considering other HIV-related risk factors, patchy correlations were found between HIV viral load, duration of ART, duration of HIV, plasma neopterin, or soluble tumor necrosis factor-alpha receptor I and vitamin D deficiency. 6,8,9,23,25,28,37,52,54,57 Adverse health outcomes related to vitamin D deficiency in HIV-infected patients Very few studies investigated the detrimental effects of vitamin D deficiency on health outcomes other than bone diseases in HIV+. They were primarily cross-sectional correlation analyses, and it was therefore not possible to establish a cause-effect relationship.…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

Vitamin D deficiency in HIV-infected patients: a systematic review

Giusti¹,

Penco²,

Pioli³

2011

NDS

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Advances in the diagnosis and management of human immunodeficiency virus (HIV) have resulted in a dramatic decrease in mortality in HIV-infected individuals (HIV+). The subsequent increase in life expectancy of HIV+ has led to the need to consider the long-term complications of the disease and its treatment. Abnormalities in vitamin D status and metabolism are increasingly recognized as a major concern in HIV infection. In the last 5 years a number of cross-sectional and prospective studies have suggested a high prevalence of vitamin D deficiency in HIV+. Although few case-control studies have been published, it has been suggested that the prevalence of hypovitaminosis D in HIV+ is higher than in the general population, and at least in part, is related to the course of the disease and/or the antiretroviral drugs used to treat the disease. An adequate vitamin D status is important not only for bone tissue, but also for the global health status of HIV+ individuals, since a growing body of evidence has demonstrated the detrimental effects of vitamin D deficiency on multiple health outcomes. Therefore, definition of the size of the problem and identification of effective protocols for the prevention and management of vitamin D deficiency in HIV+ patients represent important steps in improving health status and reducing long-term chronic complications in individuals with HIV. Due to its immunomodulatory effects, vitamin D may also have implications in the progression of HIV infection. This systematic review was designed to determine the prevalence of vitamin D deficiency in HIV+ patients; to identify risk factors (related to the HIV infection or not) potentially associated with this condition; to describe the potential consequences of hypovitaminosis D on the course of the infection and the benefits of vitamin D repletion; and to make some suggestions about the future, considering the limitations of previous studies.

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Changes in calciotropic hormones and biochemical markers of bone metabolism in patients with human immunodeficiency virus infection

Cited by 56 publications

References 21 publications

Fracture healing in HIV-positive populations

Fracture healing in HIV-positive populations

Vitamin D and Calcium Abnormalities in the HIV-Infected Population

Vitamin D deficiency in HIV-infected patients: a systematic review

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