Changes in biochemical markers of bone metabolism and BMD during the first year after a hip fracture

Hedström, Margareta; Sjöberg, Kerstin; Svensson, Jan; Brosjö, Eva; Dalén, Nils

doi:10.1080/00016470152846565

Cited by 14 publications

(7 citation statements)

References 14 publications

(9 reference statements)

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“…Similar results as ours have been reported earlier; however, the BMD examinations in these studies were performed at an average of 3–4 years after the hip fracture and not during the first weeks as in the present study . It is well known that patients suffer a rapid and pronounced loss of BMD during the first months following a hip fracture .…”

Section: Discussionsupporting

confidence: 90%

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Al-Ani

Cederholm

Sääf³

et al. 2015

Eur J Clin Investigation

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Section: Discussionsupporting

confidence: 90%

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Al-Ani

Cederholm

Sääf³

et al. 2015

Eur J Clin Investigation

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“…A vertebral compression fracture did not affect the disuse bone atrophy of the forearm, which was a nonweightbearing bone. According to published reports, BMD in the contralateral proximal femur did not recover at 48 or 52 weeks after a hip or ankle fracture [11,13]. From those previous results and our data, recovery from disuse bone atrophy could not be expected 48 weeks after fracture.…”

Section: Discussioncontrasting

confidence: 49%

Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Ohishi

Takahashi

Yamanashi

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Time-dependent changes in bone markers in delayed or nonunion of vertebral fracture were compared with those of normal union. Thirty-three patients with a fresh vertebral fracture were enrolled. Urinary Type I collagen C-terminal telopeptide, pyridinoline, deoxypyridinoline, serum C-terminal telopeptide, and N-midportion of osteocalcin (OC N-mid ) were determined at the time of hospital admission (within 24 hours after the fracture event in all cases) and at 2, 4, 12, 24, and 48 weeks thereafter.

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“…An increase in osteocalcin after a fracture episode was reported in previous studies (26). Osteocalcin is cleaved from the procollagen molecule during formation and is incorporated into bone during mineralization.…”

Section: Discussionmentioning

confidence: 82%

Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D

Hitz

Jensen

Eskildsen

2007

The American Journal of Clinical Nutrition

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Background: Low-energy fractures of the hip, forearm, shoulder, and spine are known consequences of osteoporosis. Objective: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture. Design: In a double-blinded design, patients with fracture of the hip (lower-extremity fracture, or LEF) or upper extremity (UEF) were randomly assigned to receive 3000 mg calcium carbonate ѿ 1400 IU cholecalciferolorplacebo(200IUcholecalciferol).BMDofthehip(HBMD)and lumbar spine (LBMD) were evaluated by dual-energy X-ray absorptiometry, and physical performance was assessed by the timed Up & Go test. Serum concentrations of 25-hydroxycholecalciferol, parathyroid hormone (PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-terminal propeptide of collagen type I were measured. Results: A total of 122 patients were included (84% women; x Ȁ SD age: 70 Ȁ 11 y); 68% completed the study. In an intention-to-treat analysis, LBMD increased in the intervention group and decreased in the placebo group, and the difference between the groups was significant after 12 mo: 0.931 Ȁ 0.211 compared with 0.848 Ȁ 0.194 (P 0.05). No significant change was shown for HBMD. The effect of treatment was more pronounced in patients aged 70 y. The intervention decreased bone turnover. PTH was significantly lower in the intervention group (P 0.01) for the LEF patients. ICTP and change in LBMD were significantly related to physical performance. Conclusions: A 1-y intervention with calcium and vitamin D reduced bone turnover, significantly increased BMD in patients younger than 70 y, and decreased bone loss in older patients. The effect of treatment was related to physical performance.Am J Clin Nutr 2007;86:251-9.

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Changes in biochemical markers of bone metabolism and BMD during the first year after a hip fracture

Cited by 14 publications

References 14 publications

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Low bone mineral density and fat‐free mass in younger patients with a femoral neck fracture

Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D

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