Changes in arterial function in a mouse model of human familial hypercholesterolaemia

Abstract

The study shows that reduced acetylcholine-induced dilatation is related to the presence of atherosclerosis in old ApoB mice. Remarkably, the impaired vessel reactivity to phenylephrine already in young ApoB mice indicates early changes in vascular function in this model.

Models

“…The availability of genetically modified animals allows selective modification of protein or hormone receptor expression, making murine models especially attractive in this context . Modelling the human lipoprotein constellation in atherosclerosis as best as possible is one of the targets in this context, which can be reached by combination of transgenic approaches . In the field of cardiovascular research, numerous animal models have been developed.…”