Changes in aqueous humour following single or repeated UVB irradiation of rabbit cornea

Fris, Miroslav; Čejková, Jitka; Midelfart, Anna

doi:10.1007/s00417-007-0620-7

Cited by 10 publications

(10 citation statements)

References 34 publications

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“…Thus, at this wavelength, corneal tissue absorbs the main amount of the harmful UVR energy and is supposed to be the most vulnerable segment of the eye towards the effects of UV irradiation. These presumptions were confirmed by the PCA results, both in our previous experiments [12,14] and the present study. As apparent in Fig.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, a concomitant significant reduction in the contents of myoinositol (16% for UVB1, 31% for UVB2) and taurine (10% for UVB1, 46% for UVB2), compounds with osmoregulative properties, further supports possible stimulation of other osmotic regulation systems. However, simultaneous increase in the concentrations of these metabolites in the aqueous humour was not found after UVB irradiation of those eyes in our previous study [12], which might imply involvement of other depletion mechanisms.…”

Section: Discussionmentioning

confidence: 66%

“…This enzyme converts glucose to sorbitol, which is not able to escape from the cell and which can generate high intracellular osmotic pressure sufficient to burst lens cells [5]. A significantly high glucose level in the UVR-B exposed aqueous humour samples found in our last study [12] may simulate the diabetic model, and would explain the elevation in sorbitol concentration following the UVB irradiation. Moreover, a concomitant significant reduction in the contents of myoinositol (16% for UVB1, 31% for UVB2) and taurine (10% for UVB1, 46% for UVB2), compounds with osmoregulative properties, further supports possible stimulation of other osmotic regulation systems.…”

Section: Discussionmentioning

confidence: 87%

“…The resonances of other metabolites either overlapped each other or the signal to cornea -e, f) [12,14]. Score plot representation (a, c, e); loading profile of PC1 (b, d, f).…”

Section: Resultsmentioning

confidence: 98%

“…In our previous experiments [12,14], a substantial cumulative effect of UVR-B on the metabolic profiles of rabbit cornea and aqueous humour was revealed. By using identical experimental design, the purpose of the present study was to investigate alterations in the rabbit lens, obtained from the same eye as the recently examined corneal and aqueous humour samples, and thereby supplement and complete the findings of our prior investigations.…”

Section: Introductionmentioning

confidence: 97%

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The effect of single and repeated UVB radiation on rabbit lens

Fris

Čejková

Midelfart

2008

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 87%

“…The resonances of other metabolites either overlapped each other or the signal to cornea -e, f) [12,14]. Score plot representation (a, c, e); loading profile of PC1 (b, d, f).…”

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

The effect of single and repeated UVB radiation on rabbit lens

Fris

Čejková

Midelfart

2008

Graefes Arch Clin Exp Ophthalmol

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Metabolomics of the aqueous humor in the rat glaucoma model induced by a series of intracamerular sodium hyaluronate injection

Mayordomo-Febrer

López-Murcia

Morales-Tatay

et al. 2015

Experimental Eye Research

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The human health effects of ozone depletion and interactions with climate change

Norval

Lucas

Cullen

et al. 2011

Photochem Photobiol Sci

190

124

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Depletion of the stratospheric ozone layer has led to increased solar UV-B radiation (280-315 nm) at the surface of the Earth. This change is likely to have had an impact on human exposure to UV-B radiation with consequential detrimental and beneficial effects on health, although behavioural changes in society over the past 60 years or so with regard to sun exposure are of considerable importance. The present report concentrates on information published since our previous report in 2007. The adverse effects of UV radiation are primarily on the eye and the skin. While solar UV radiation is a recognised risk factor for some types of cataract and for pterygium, the evidence is less strong, although increasing, for ocular melanoma, and is equivocal at present for age-related macular degeneration. For the skin, the most common harmful outcome is skin cancer, including melanoma and the non-melanoma skin cancers, basal cell carcinoma and squamous cell carcinoma. The incidence of all three of these tumours has risen significantly over the past five decades, particularly in people with fair skin, and is projected to continue to increase, thus posing a significant world-wide health burden. Overexposure to the sun is the major identified environmental risk factor in skin cancer, in association with various genetic risk factors and immune effects. Suppression of some aspects of immunity follows exposure to UV radiation and the consequences of this modulation for the immune control of infectious diseases, for vaccination and for tumours, are additional concerns. In a common sun allergy (polymorphic light eruption), there is an imbalance in the immune response to UV radiation, resulting in a sun-evoked rash. The major health benefit of exposure to solar UV-B radiation is the production of vitamin D. Vitamin D plays a crucial role in bone metabolism and is also implicated in protection against a wide range of diseases. Although there is some evidence supporting protective effects for a range of internal cancers, this is not yet conclusive, but strongest for colorectal cancer, at present. A role for vitamin D in protection against several autoimmune diseases has been studied, with the most convincing results to date for multiple sclerosis. Vitamin D is starting to be assessed for its protective properties against several infectious and coronary diseases. Current methods for protecting the eye and the skin from the adverse effects of solar UV radiation are evaluated, including seeking shade, wearing protective clothing and sunglasses, and using sunscreens. Newer possibilities are considered such as creams that repair UV-induced DNA damage, and substances applied topically to the skin or eaten in the diet that protect against some of the detrimental effects of sun exposure. It is difficult to provide easily understandable public health messages regarding "safe" sun exposure, so that the positive effects of vitamin D production are balanced against the negative effects of excessive exposure. The international response to ozone depl...

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Changes in aqueous humour following single or repeated UVB irradiation of rabbit cornea

Abstract: Application of a Carr-Purcell-Meiboom-Gill spin echo pulse sequence was found to have a great advantage for correct analysis of the results obtained with NMR spectroscopy of aqueous humour from eyes where increase of protein level due to an inflammatory process could not be excluded.

Cited by 10 publications

References 34 publications

The effect of single and repeated UVB radiation on rabbit lens

The effect of single and repeated UVB radiation on rabbit lens

Metabolomics of the aqueous humor in the rat glaucoma model induced by a series of intracamerular sodium hyaluronate injection

The human health effects of ozone depletion and interactions with climate change

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