Changes in appetite hormone (ghrelin) levels of saliva and serum in acute appendicitis cases before and after operation

Çetinkaya, Ziya; Aydın, Süleyman; Cerrahoglu, Yusuf Ziya; Ayten, Refik; Erman, Fazilet; Aygen, Erhan

doi:10.1016/j.appet.2008.09.001

Cited by 13 publications

(15 citation statements)

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“…When analyzing the groups individually, this also held true for the morbidly obese and healthy subjects. These findings are in line with most of the studies which reported higher ghrelin levels in saliva compared to serum for healthy adults, epileptic patients, and patients with end-stage renal disease [2,[20][21][22]. In a study by Dynesen et al, ghrelin was found to be in the same range of concentrations in blood and saliva, both in healthy women and female patients with bulimia nervosa [17].…”

Section: Discussionsupporting

confidence: 91%

Comparison of Serum and Salivary Ghrelin in Healthy Adults, Morbidly Obese, and Patients with Metastatic Carcinoma

et al. 2010

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Section: Discussionsupporting

confidence: 91%

Comparison of Serum and Salivary Ghrelin in Healthy Adults, Morbidly Obese, and Patients with Metastatic Carcinoma

et al. 2010

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“…In a trial conducted by Cetinkaya et al (9), ghrelin levels in the preoperative serum and saliva samples of appendectomy patients were reported to be lower compared to values in the postoperative period and in healthy controls. The authors suggested that the observed decrease in ghrelin levels may be due to the loss of appetite in acute appendicitis.…”

Section: Introductionmentioning

confidence: 99%

Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis

Kanat¹,

Ayten²,

Aydın³

et al. 2014

Turk J Gastroenterol

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Background/Aims: Due to risk of morbidity and mortality, various tests and scoring systems used in the assessment of the diagnosis and severity of acute pancreatitis disease are gaining more importance every day. Most of the current scoring systems, validated by various parameters, have a sophisticated and complex structure. Research is ongoing to establish a method to diagnose the disease and determine the severity by using different and simple parameters. In this trial, we aimed to investigate the role of the orexigenic "ghrelin" and anorexigenic "obestatin" hormones, if any, on the diagnosis and assessment of the severity of acute pancreatitis. Materials and Methods: A total of 30 patients hospitalized between September 2009 and September 2010 with a diagnosis of acute pancreatitis (AP) and 25 healthy volunteers were enrolled in the trial with a prospective and randomized design. The patients were classified in two groups, mild (Ranson ≤3 and / or Apache II ≤8) and severe (Ranson >3 and/or Apache II >8) cases, as per the Ranson and Apache-II criteria; the ghrelin and obestatin levels in blood samples obtained from the patients were measured using the ELISA method. Results: Twenty-two of the 30 patients (73%) were regarded as mild pancreatitis cases, while 8 cases (27%) were diagnosed as severe pancreatitis. Comparison of the mild and severe pancreatitis groups did not reveal a statistical difference between the two groups in terms of acylated and de-acylated ghrelin values on presentation and following the initiation of oral feeding. Similarly, no significant difference was found in the comparison of the patient and the control groups in terms of acylated and de-acylated ghrelin values on presentation (p=0.863). On the other hand, acylated and de-acylated ghrelin values after initiation of oral feeding were observed to be higher in the patient group (p=0.001, p=0.000). Comparison of these two groups revealed a significant difference in obestatin values, both on presentation and after initiation of oral feeding (p=0.002 and p=0.000). Conclusion: Consistently high serum ghrelin values during pancreatic inflammation suggest that ghrelin may be used as an adjunctive parameter in the monitoring of the course of the disease. On the other hand, high obestatin values in patients on presentation indicate that this hormone is a more significant parameter in terms of diagnosis. However, no correlation was established between these two peptide hormones and the severity of AP.

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“…We consider that this increase in the NUCB2/nesfatin-1 levels was caused by additional surgical stress. Similarly, Cetinkaya et al [8] reported an increase in ghrelin levels after surgical stress had subsided. It has been also shown that abdominal surgery in rats induces a potent decrease of ghrelin levels [24].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the sensitivity and specificity of the serum ghrelin level for detection of acute appendicitis have recently been evaluated. Cetinkaya et al [8] found that the preoperative ghrelin levels in saliva and serum were significantly lower than the postoperative levels in both patients undergoing appendectomy and control patients. They concluded that low serum ghrelin levels in patients with acute appendicitis might aid in the diagnosis of this condition.…”

Section: Discussionmentioning

confidence: 99%

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Leptin and NUCB2/Nesfatin-1 in Acute Appendicitis

Bakal¹,

Saraç²,

Çiftçi³

et al. 2015

IJCM

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Objective: Appetite loss is seen in 90% to 95% of patients with acute appendicitis; however, the cause of this symptom remains unknown. This study is performed to determine whether changes in the blood levels of two anorexigenic hormones, leptin and NUCB2/nesfatin-1, can help to diagnose acute appendicitis in children and whether these two parameters can distinguish acute appendicitis from abdominal pain. Methods: Sixty children with comparable ages and body mass indices are divided into three groups of 20 children each: those with acute appendicitis, those with abdominal pain, and controls. The blood sample with acute appendicitis is taken preoperatively (T1), and subsequent samples are taken 24 hrs postoperatively (T2) and 3 days postoperatively (T3). The blood sample with abdominal pain subjects is also taken in the corresponding times with those with acute appendicitis while blood sample from controls is only taken in the T1 corresponding time. Leptin and NUCB2/nesfatin-1 levels are measured by enzyme-linked immunosorbent assay. Results: The serum leptin levels are significantly higher preoperatively than postoperatively in all three groups. The NUCB2/nesfatin-1 levels at T1 in acute appendicitis are significantly higher than those at T2 in all three groups, but are restored at T3 to levels similar to those of controls. Neutrophil percentage has a sensitivity of 100%, and specificity of 76.32%, NUCB2/ nesfatin-1 level has a sensitivity of 47% and specificity of 95%, and the leptin level has a sensitivity of 64% and specificity of 51% in the diagnosis of acute appendicitis. Conclusions: High preoperative leptin and NUCB2/nesfatin-1 levels may be a causative factor for appetite suppression observed in patients with acute appendicitis. High preoperative and low postoperative serum leptin and NUCB2/nesfatin-1 concentrations may serve as new candidate biomarkers that help to distinguish acute appendicitis from abdominal pain in children in addition to high CRP concentration, high WBC count, and neutrophilia.

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Changes in appetite hormone (ghrelin) levels of saliva and serum in acute appendicitis cases before and after operation

Cited by 13 publications

References 14 publications

Comparison of Serum and Salivary Ghrelin in Healthy Adults, Morbidly Obese, and Patients with Metastatic Carcinoma

Comparison of Serum and Salivary Ghrelin in Healthy Adults, Morbidly Obese, and Patients with Metastatic Carcinoma

Significance of appetite hormone ghrelin and obestatin levels in the assessment of the severity of acute pancreatitis

Leptin and NUCB2/Nesfatin-1 in Acute Appendicitis

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