Changes in apoptosis of human polymorphonuclear granulocytes with aging

Fülöp, Tamás; Fouquet, Caroline; Allaire, P; Perrin, Nina Elisabeth Staffansdotter Sohlman; Lacombe, Guy; Staňková, Jana; Rola‐Pleszczynski, Marek; Gagné, Danièle; Wagner, J. Richard; Khalil, Abdelouahed; Dupuis, Gilles

doi:10.1016/s0047-6374(96)01881-7

Cited by 128 publications

(38 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, carried out on patients with sepsis, we observed greater neutrophil apoptosis in those with higher levels of blood glucose level and lactate level and lesser as age increased. These findings are concordant with those observed in medical literature and described under different conditions [27,28]. We believe that, as this study was not designed to clarify these issues, other studies should be carried out aimed at analyzing them in more detail.…”

Section: Discussionsupporting

confidence: 92%

“…Different factors have been cited as being able to influence neutrophil apoptosis (age, blood glucose level, corticoids, hypoxia, tobacco, etc) [27,28]; however, they have not been analyzed in patients with sepsis. In our study, carried out on patients with sepsis, we observed greater neutrophil apoptosis in those with higher levels of blood glucose level and lactate level and lesser as age increased.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors

Tamayo

Gómez

Bustamante

et al. 2012

Journal of Critical Care

View full text Add to dashboard Cite

Purpose:The aims were to analyze the temporal evolution of neutrophil apoptosis, to determine the differences in neutrophil apoptosis among 28-day survivors and nonsurvivors, and to evaluate the use of neutrophil apoptosis as a predictor of mortality in patients with septic shock. Materials and Methods: Prospective multicenter observational study carried out between July 2006 and June 2009. The staining solution study included 80 patients with septic shock and 25 healthy volunteers. Neutrophil apoptosis was assessed by fluorescein isothiocyanate (FITC)-conjugated annexin V and aminoactinomycin D staining. Results: The percentage of neutrophil apoptosis was significantly decreased at 24 hours, 5 days, and 12 days after the diagnosis of septic shock (14.8% ± 13.4%, 13.4% ± 8.4%, and 15.4% ± 12.8%, respectively; P b .0001) compared with the control group (37.6% ± 12.8%). The difference in apoptosis between 28-day surviving and nonsurviving patients was nonsignificant (P N .05). The mortality rate at 28 days was 53.7%. Journal of Critical Care (2012) 27, 415.e1-415.e11 The crude hazard ratio for mortality in patients with septic shock did not differ according to the percentage of apoptosis (hazard ratio, 1.006; 95% confidence interval, 0.98-1.03; P = .60). Conclusions: During the first 12 days of septic shock development, the level of neutrophil apoptosis decreases and does not recover normal values. No differences were observed between surviving and nonsurviving patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors

Tamayo

Gómez

Bustamante

et al. 2012

Journal of Critical Care

View full text Add to dashboard Cite

show abstract

“…Neutrófilos Se altera su apoptosis 27 y, aun cuando su capacidad para fagocitar no se modifica, la destrucción de microorganismos fagocitados disminuye, 28 así como su reclutamiento y migración, lo cual afecta la cantidad que accede al sitio dañado. Las quimiocinas no se modifican, pero puede alterarse su receptor en el neutrófilo y, consecuentemente, la señalización, lo cual disminuiría su actividad en la inflamación aguda.…”

Section: Inmunidad Naturalunclassified

Senescencia del sistema inmune y alteraciones relacionadas con el asma

Vega-Robledo

Rico-Rosillo

2017

RAM

View full text Add to dashboard Cite

Senescence is an irreversible process by which cells enter to a permanent cell cycle arrest with generalized molecular changes. Senescent cells remain metabolically active and most of them show a secretory phenotype; through its secretion may induce senescence or cancer in other cells. The secretory cells in the so-called transient senescence may participate in embryogenesis, tissue regeneration and immune response. The deleterious changes associated with age affect the immune system members and the immune senescence cause poor response to vaccines and susceptibility to cancer and infections. These latter are a frequent cause of asthma mostly in the elderly, the incidence is increasing in old people, and it may be related with those anatomical, physiological and immune changes caused by age, asthma chronicity and external agents. Comorbidity in the elderly worsens the ailment and hinders diagnosis, therefore, knowledge and handling of these clinical entities must be in control by the physicians responsible of the first level attention to old patients. Senescencia del sistema inmune y alteraciones relacionadas con el asma

show abstract

“…To date several functions are reduced with aging, including phagocytosis, chemotaxis, and intracellular killing via free radical production [15][16][17]. Homeostasis of neutrophils is also changed as their susceptibility to spontaneous and induced apoptosis is increased in aged individuals [18]. The functional changes observed to date suggest that neutrophil functions are severely compromised with aging.…”

Section: How Aging Affects Neutrophilsmentioning

confidence: 99%

“…• Chemotaxis decreased or no change [15,16,17] Free radical production decrease [15,16,17] Intracellular killing decreased [15,16,17] Rescue from apoptosis decreased [18] Intracellular signalling altered [14,19,20 Free radical production decrease [56] Intracellular killing decrease [56] Pro-inflammatory cytokine production increased [47,48,54,57] Intracellular signalling altered [29,47,48,49] Dendritic cells Phenotype no change or decrease [47,63,64] Subpopulations no change [63,64] Receptors number decrease or no change [29,65] Functions Phagocytosis decrease or no change [63,72,73] Antigen presentation decreased [63,72] Chemotaxis decreased [73] Intracellular killing decrease [63] Pro-inflammatory cytokine production increased [63,66,68] T cell priming altered [63,72] Cytokine production decreased or no change [84,88] T cell priming altered …”

Section: Innate Immunosenescence and Age-associated Pathologiesmentioning

confidence: 99%

The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

Fülöp

Fortin²,

Lesur³

et al. 2012

TOLSJ

View full text Add to dashboard Cite

Abstract:The immune system plays an important role in the defence against various threats to health, such as pathogens, cancer cells or modified-self proteins. With aging there is a decrease in the immune response, called immunosenescence, concomitantly with the increase in some age-related diseases such as infections, autoimmune disorders, chronic inflammatory diseases and cancer. The immune response is traditionally divided between innate and adaptive immune responses. Accumulating evidence suggests that immunosenescence is not only restricted to the adaptive but also affects the innate immune system. Assessment of innate immune system functions revealed that it is also susceptible to age-related dysregulation. Furthermore, it is becoming clear that the sustained function of innate cells is indispensable for the adequate functioning of the adaptive immune response. This review will describe the changes in the innate immune response with aging and the recent discoveries, which may shed new light on its contribution to immunosenescence.

show abstract

Changes in apoptosis of human polymorphonuclear granulocytes with aging

Cited by 128 publications

References 47 publications

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors

Senescencia del sistema inmune y alteraciones relacionadas con el asma

The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

Contact Info

Product

Resources

About