Changes in antimicrobial resistance phenotypes and genotypes in &lt;i&gt;Streptococcus suis&lt;/i&gt; strains isolated from pigs in the Tokai area of Japan

Ichikawa, Takashi; Oshima, Masaaki; Yamagishi, Junjiro; Muramatsu, Chieko; Asai, Tetsuo

doi:10.1292/jvms.19-0449

Cited by 19 publications

(20 citation statements)

References 26 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Worldwide antimicrobial resistance data available for S. suis indicate that most isolates recovered from both humans and pigs have high resistance to tetracycline and moderate to high resistance to macrolides, e.g., erythromycin [ 12 , 13 , 14 , 15 , 16 , 17 , 19 , 22 ]. Our study confirms those observations.…”

Section: Discussionmentioning

confidence: 99%

“…One reason for this is that antimicrobial resistance data for S. suis continue to be scarce. Furthermore, most available antimicrobial resistance data have been generated by investigating S. suis isolates recovered from pigs [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ], whereas those for human S. suis isolates are minimal [ 16 , 18 , 19 , 20 ]. The mass use of antibiotics in the livestock industry in many countries, especially in pigs for growth promotion, routine prophylaxis, or treatment for controlling the spread of infection, has potentially led to antimicrobial resistance in the microbial communities of food animal production under such conditions [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Non-Penicillin-Susceptible Streptococcus suis Isolated from Humans

et al. 2021

View full text Add to dashboard Cite

Streptococcus suis is a pathogen that causes invasive infections in humans and pigs. In this study, 448 S. suis isolates recovered from human infections in Thailand were characterized with regard to their antimicrobial susceptibility and antimicrobial resistance genes, including, for non-penicillin-susceptible isolates, sequence analyses of five genes encoding penicillin-binding proteins (pbp1a, pbp1b, pbp2a, pbp2b, and pbp2x). All 448 isolates were susceptible to cefepime and ceftriaxone, whereas 99.6%, 91.7%, and 72.9% of the isolates were susceptible to levofloxacin, penicillin, and chloramphenicol, respectively. Almost all isolates were resistant to tetracycline (98.2%), clindamycin (94%), erythromycin (92.4%), and azithromycin (82.6%). Genes tet(O) and ermB were the predominant resistance genes detected among macrolide- and tetracycline-resistant isolates. A total of 37 out of 448 isolates (8.2%) showed intermediately resistance to penicillin. Most of these isolates (59.5%) belonged to serotype 2-ST233. Comparison of the predicted translated sequences of five PBP proteins of a penicillin-susceptible isolate (strain P1/7) to the respective PBP sequences of ten non-penicillin-susceptible isolates revealed multiple amino acid substitutions. Isolates of CC221/234 showed highly variable amino acid substitutions in all PBP proteins. An ST104 isolate had a higher number of amino acid substitutions in PBP2X. Isolates belonging to CC233/379 had numerous substitutions in PBP2B and PBP2X. ST25 isolates exhibited fewer amino acid substitutions than isolates of other STs in all five PBPs. The antimicrobial resistance of S. suis is increasing worldwide; therefore, restrictions on antimicrobial use, continuous control, and the surveillance of this bacterium throughout the pork supply chain are crucial for ensuring public health and must be a priority concern.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-Penicillin-Susceptible Streptococcus suis Isolated from Humans

et al. 2021

View full text Add to dashboard Cite

show abstract

“…2014), the Tokai area of Japan (56·1%) (Ichikawa et al . 2020) and Guwahati of India (0%) (Devi et al . 2017).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance phenotypes and genotypes of Streptococcus suis isolated from clinically healthy pigs from 2017 to 2019 in Jiangxi Province, China

Tan

Zeng

et al. 2020

J. Appl. Microbiol.

View full text Add to dashboard Cite

Aims This study aimed to investigate the antimicrobial resistance (AMR) profiles and genotypes of Streptococcus suis from Jiangxi Province, China. Methods and Results A total of 314 nasal swab samples were collected from clinically healthy pigs, with a positive isolation rate of S. suis of 34·08%. Antimicrobial susceptibility testing showed that more than 80% of the isolates were susceptible to vancomycin, penicillin, minocycline and chloramphenicol. A high frequency of resistance to clindamycin, tetracycline, clarithromycin and erythromycin was observed. All of the isolates were resistant to three or more categories of antimicrobials. The erm(B) and tet(O) served as the most frequent genotypes that contributed to lincosamide, macrolide and tetracycline resistances. A part of macrolide‐resistant genotypes could not exhibit specific phenotypes. Finally, integrative and conjugative elements (ICEs) were identified in 28·97% of the isolates. Conclusions The multidrug resistance of S. suis has widely emerged in Jiangxi Province. The most prevalent resistance genes and genotypes were similar to those in other regions or countries. The presence of ICEs is increasing the risk of horizontal transfer of AMR genes. Significance and Impact of the Study The findings could provide guidance for the rational use of antimicrobial drugs and be helpful for monitoring the AMR information of S. suis in China.

show abstract

“…The WHO classified phenicols (recently renamed as amphenicols) as “highly important antimicrobials” [ 22 ]. Amphenicol resistance in S. suis is scarce in Europe [ 21 , 35 , 36 , 54 ] compared to the rates observed in Asia (up to 41% of resistance) [ 24 , 43 , 55 , 56 ]. Amphenicol resistance is mediated by several mechanisms in S. suis .…”

Section: Mechanisms Of Antimicrobial Resistance (Amr) and Resistance Genes Found In S Suismentioning

confidence: 99%

Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen Streptococcus suis

Dechêne-Tempier

Marois-Créhan²,

Libante

et al. 2021

Microorganisms

View full text Add to dashboard Cite

Streptococcus suis is a zoonotic pathogen causing important economic losses in swine production. The most commonly used antibiotics in swine industry are tetracyclines, beta-lactams, and macrolides. Resistance to these antibiotics has already been observed worldwide (reaching high rates for macrolides and tetracyclines) as well as resistance to aminoglycosides, fluoroquinolones, amphenicols, and glycopeptides. Most of the resistance mechanisms are encoded by antibiotic resistance genes, and a large part are carried by mobile genetic elements (MGEs) that can be transferred through horizontal gene transfer. This review provides an update of the resistance genes, their combination in multidrug isolates, and their localization on MGEs in S. suis. It also includes an overview of the contribution of biofilm to antimicrobial resistance in this bacterial species. The identification of resistance genes and study of their localization in S. suis as well as the environmental factors that can modulate their dissemination appear essential in order to decipher the role of this bacterium as a reservoir of antibiotic genes for other species.

show abstract

Changes in antimicrobial resistance phenotypes and genotypes in <i>Streptococcus suis</i> strains isolated from pigs in the Tokai area of Japan

Cited by 19 publications

References 26 publications

Non-Penicillin-Susceptible Streptococcus suis Isolated from Humans

Non-Penicillin-Susceptible Streptococcus suis Isolated from Humans

Antimicrobial resistance phenotypes and genotypes of Streptococcus suis isolated from clinically healthy pigs from 2017 to 2019 in Jiangxi Province, China

Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen Streptococcus suis

Contact Info

Product

Resources

About