Changes in antigenicity of basement membrane during wound healing

Ld, Johnson; Gb, Pierce

doi:10.1016/0012-1606(70)90139-9

Cited by 11 publications

(2 citation statements)

References 14 publications

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“…Immediately below the EBP cells, peduncle epidermal cells are also observed to phagocytose their basal lamina. During wound healing in the mouse, it has been reported that a collagenase produced by epidermal cells brings about basal lamina degeneration (Johnson & Pierce, 1970). It is conceivable that a similar enzyme may initiate the degeneration of the basal lamina in the peduncle prior to its phagocytosis.…”

Section: Discussionmentioning

confidence: 99%

Tissue abscission and wound healing in the operculum of Pomatoceros lamarckii Quatrefages (Polychaeta: Serpulidae)

Bubel

Thorp

1985

Journal of Zoology

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Following opercular amputation in Pomatoceros lamarckii Quatrefages, wound healing is initiated from a predetermined point on the peduncle. The events of abscission, cell migration and cuticle deposition during wound healing have been studied by light and electron microscopy. Abscission occurs at a predetermined point on the peduncle indicated by specialized epidermal cells, the easy break‐point cells (EBP). Following detachment of tissues distal to the EBP cells, the resultant wound is plugged by a knot of coelomocytes which provide a substratum over which epidermal cells migrate to seal and restore the epidermis. During their migration, the epidermal cells undergo differentiation and deposit a new cuticle. Cuticle formation is initiated by the deposition of a finely filamentous matrix. The fine filaments subsequently coalesce to form thicker fibrils which become aggregated into layers of orthogonally‐arranged fibril bundles. The mechanisms involved in abscission, cell migration and cuticle deposition during wound healing of the opercular filament are discussed.

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Section: Discussionmentioning

confidence: 99%

Tissue abscission and wound healing in the operculum of Pomatoceros lamarckii Quatrefages (Polychaeta: Serpulidae)

Bubel

Thorp

1985

Journal of Zoology

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“…The absence of a basement membrane between the AEC and the underlying mesenchyme is characteristic of epimorphic regeneration. In mammalian wound healing the basement membrane of the skin is fully reconstituted by 72 h after injury ( Johnson & Pierce 1970) impeding the free diffusion of molecules between the epidermis and mesenchyme.…”

Section: Introductionmentioning

confidence: 99%

Expression of FGF2 in the limb blastema of two Salamandridae correlates with their regenerative capability

Giampaoli

Bucci

Ragghianti

et al. 2003

Proc. R. Soc. Lond. B

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Limb regenerative potential in urodeles seems to vary among different species. We observed that Triturus vulgaris meridionalis regenerate their limbs significantly faster than T. carnifex, where a long gap between the time of amputation and blastema formation occurs, and tried to identify cellular and molecular events that may underlie these differences in regenerative capability. Whereas wound healing is comparable in the two species, formation of an apical epidermal cap (AEC), which is required for blastema outgrowth, is delayed for approximately three weeks in T. carnifex. Furthermore, fewer nerve fibres are present distally early after amputation, consistent with the late onset of blastemal cell proliferation observed in T. carnifex. We investigated whether different expression of putative blastema mitogens, such as FGF1 and FGF2, in these species may underlie differences in the progression of regeneration. We found that whereas FGF1 is detected in the epidermis throughout the regenerative process, FGF2 onset of expression in the wound epidermis of both species coincides with AEC formation and initiation of blastemal cell proliferation, which is delayed in T. carnifex, and declines thereafter. In vitro studies showed that FGF2 activates MCM3, a factor essential for DNA replication licensing activity, and can be produced by blastemal cells themselves, indicating an autocrine action. These results suggest that FGF2 plays a key role in the initiation of blastema growth.

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An in vitro and in vivo study of single palatal processes

Smilay

Koah

1972

Anat. Rec.

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Single palatal processes were grown in organ culture to test whether epithelial contact was a prerequisite for the cytological alterations observed during midline epithelial disruption. Observations were made with the light and electron microscopes. Palatal processes from 14 day C57BL mice were cultured on Millipore filters and fixed in paraformaldehyde and osmium tetroxide. Fine structure studies of 24 hour cultures revealed a thick basal lamina beneath an intact epithelium. Epithelial cells were absent along the medial edge of the palatal process in 48 hour cultures. Mesenchymal cells, not covered by a basal lamina, ultimately occupied the original position of the epithelial cells. Single palatal processes taken from spontaneous cleft A/Jax fetuses showed epithelial cell death along the medial edge similar to that in. nitro, although an epithelialfree surface was not observed. We interpreted these observations to indicate that epithelial cell disruption was an inherent process of medial palatal epithelium. This disruption was exaggerated during organ culture by the mesenchymal cells spreading on the filter membrane.

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Changes in antigenicity of basement membrane during wound healing

Cited by 11 publications

References 14 publications

Tissue abscission and wound healing in the operculum of Pomatoceros lamarckii Quatrefages (Polychaeta: Serpulidae)

Tissue abscission and wound healing in the operculum of Pomatoceros lamarckii Quatrefages (Polychaeta: Serpulidae)

Expression of FGF2 in the limb blastema of two Salamandridae correlates with their regenerative capability

An in vitro and in vivo study of single palatal processes

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