Changes in Antibody Titers and Serum Protein Fractions during the Course of Prolonged Infections with Vivax or with Falciparum malaria

Js, Lunn; Chin, William; Pg, Contacos; Gr, Coatney

doi:10.4269/ajtmh.1966.15.3

Cited by 19 publications

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“…Neutralizing antibody were detected in these two sloth species, despite they were virtually absent from other wild vertebrate species tested. Several strains were associated with prolonged or recrudescent viremias in slots [130]. Besides, one strain of Changuinola virus was identified from a febrile patient [8].…”

Section: Reoviridae Familymentioning

confidence: 99%

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

Ayhan¹,

Charrel²

2019

Vectors and Vector-Borne Zoonotic Diseases

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Sandflies show distribution in a vast geographical area from Europe to Asia, Africa, Australia, and Central and South America where they can transmit a large number of viruses. Between these viruses, the most important are grouped into the Phlebovirus genus (family Phenuiviridae). Among them, several sandfly-borne phleboviruses cause self-limiting febrile disease (sandfly fever) or central and peripheral nervous system infections. Data concerning the geographic distribution of these phleboviruses has drastically increased during the last decade in both the new and the old worlds. The current situation depicts a high viral diversity with taxonomic groups containing human pathogenic and non-pathogenic viruses. This merits to provide insight to address the question of medical and veterinary public health impact of all these viruses, which are poorly studied. To do so, integrated and translational approaches must use ecological, epidemiological, serological and direct clinical evidence. Beside, other viruses transmitted by sandflies and belonging to Rhabdoviridae and Reoviridae families can also be of veterinary and public health importance. The chapter aims to provide a comprehensive view of the sandfly-borne viral pathogens of the public health impact on humans and other vertebrates in the old and new worlds.

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Section: Reoviridae Familymentioning

confidence: 99%

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

Ayhan¹,

Charrel²

2019

Vectors and Vector-Borne Zoonotic Diseases

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“…Lunn et al 18 estudaram a resposta de anticorpos à malária por P. vivax e por P. falciparum em ataques primários induzidos e recaídas e/ou recrusdecências. As recaídas por P. vivax demonstraram duas respostas distintas.…”

Section: Comentários E Discussãounclassified

Resposta de anticorpos IgG anti-Plasmodium vivax em crianças expostas à malária, antes e após tratamento específico

Pinto¹,

Ventura²,

Souza³

2001

J. Pediatr. (Rio J.)

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ResumoObjetivos: avaliar a resposta de anticorpos IgG anti-P. vivax (IgG anti-PV) e suas subclasses citofílicas (IgG1 e IgG3) e não citofílicas (IgG2), em 34 crianças com malária por P. vivax, de 0 a 15 anos de idade.Método: os níveis de anticorpos IgG foram mensurados pela técnica de imunofluorescência indireta, durante a fase aguda e de controle de cura. Os pacientes foram distribuídos em dois grupos, de priminfectados e pacientes com história de malária anterior. Os níveis de anticorpos no dia do início do tratamento (ou dia zero) e no último dia de tratamento (ou D7) foram comparados (teste t de Student) e correlacionados com a parasitemia assexuada nos dois grupos (Correlação de Spearman).Resultados e conclusões: foi observado aumento inicial significativo dos títulos de IgG anti-PV no início e no final do tratamento. As médias geométricas dos títulos de subclasses de IgG anti-PV encontradas nos pacientes com história prévia de malária foram IgG1 (806,35) > IgG3 (28,28) > IgG2 (20). Nos pacientes priminfectados as respostas obtidas foram IgG1 (709,21) > IgG3 (39,3) > IgG2 (10,7). Não ocorreu associação entre parasitemia assexuada e títulos de IgG anti-PV no primeiro dia de tratamento. Houve predominância de anticorpos citofílicos (IgG1> IgG3) sobre os não citofílicos.J Pediatr (Rio J) 2001; 77 (4):299-306: malária vivax, anticorpos IgG, anticorpos citofílicos, crianças. AbstractObjective: to assess the IgG antibody response against P. vivax (IgG anti-PV), and cytophilic (IgG1 and IgG3) and noncytophilic (IgG2) IgG subclasses in 34 children aged 0 to 15 years old infected with P. vivax malaria.Methods: IgG levels were determined by indirect fluorescent antibody technique during the acute and therapeutic control phase. Patients were distributed into 2 groups according to the presence or absence of a previous malaria episode. IgG anti-PV levels were measured on the first and last day of treatment, and compared by Student's t test. Antibody levels were correlated with asexual parasitemia (Spearman's correlation test).Results and conclusions: increased IgG levels were observed on the first and on the last day of treatment. The geometric means for IgG subclass titers found in patients with previous history of malaria were: IgG1 (806.35) > IgG3 (28.28) > IgG2 (20). In patients infected for the first time, the responses obtained were: IgG1 (709.21) > IgG3 (39.3) > IgG2 (10.7). There was no association between asexual parasitemia and antibody levels on the first day of treatment. Cytophilic antibodies (IgG1, IgG3) predominated over noncytophilic antibodies (IgG2).J Pediatr (Rio J) 2001; 77 (4):299-306: vivax malaria, antibodies IgG, cytophilic antibodies, children. Resposta de anticorpos IgG anti-Plasmodium vivax em crianças expostas à malária, antes e após tratamento específicoIgG antibody response against Plasmodium vivax in children exposed to malaria before and after specific treatment As estratégias para enfrentar o problema da malária em crianças devem ser consideradas dentro do enfoque atual que os programas ...

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“…Η παραμονή των αντισωμάτων είναι από 6 μήνες μέχρι 2 χρόνια για το P. Falciparum ), άνω των 6 ετών για το P. Vivax (Ambroise Thoma 1969) και άνω των 15 ετών για το Π. Malariae (Dranga 1969) μετά από την τελευταία λοίμωξη ή επαναλοίμωξη. Εκτός όμως από τη πρωτομόλυνση και τις επαναμολύνσεις που οφείλονται σε εξωτερικούς αντιγονικοιύς ερεθισμούς η παρουσία ενδοηπατικών παρασίτων (ιδίως P. Malariae, P. Vivax, P. Ovale) μπορεί να προκαλέσουν υποτροπή της νόσου και ανύψωση των αντισωμάτων αρ κετά χρόνια μετά την πρωτολοίμωξη (μέχρι 2 χρόνια για το P. Vivax, τουλάχιστον 5 χρόνια για-<το Ο. Ovale (Lunn 1966, Gentil'mi 1982. Στις περιπτώσεις αυτές όμως η παρασιταιμία είναι πολύ μικρή και αρά ο αντιγονικός ερεθισμός συγκριτικά μικρότερος (Voller 1962, Ambroise-Thomas 1969).…”

Section: συζητησηunclassified

Ορο - Επιδημιολογικη Μελετη Της Ελονοσιας Στο Νομο Εβρου

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Changes in Antibody Titers and Serum Protein Fractions during the Course of Prolonged Infections with Vivax or with Falciparum malaria

Cited by 19 publications

References 0 publications

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

Resposta de anticorpos IgG anti-Plasmodium vivax em crianças expostas à malária, antes e após tratamento específico

Ορο - Επιδημιολογικη Μελετη Της Ελονοσιας Στο Νομο Εβρου

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