Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children

Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized controlled trial

“…Althrough our intervention led to a greater weight loss in the DCIA compared with the SIA (Larsen et al, 2015), no intevention effects were observed on MCP1. Similarly, Roth et al (2011) showed that MCP1 was not significantly changed in children who successfully lost weight after a lifestyle intervention (physical activity, nutrition education and behavior therapy). Adiponectin is an anti-inflammatory adipokine and plays a protective role against metabolic disorder (Ouchi et al, 2011).…”

CCL2 level is elevated with metabolic syndrome and CXCL10 level is correlated with visceral fat area in obese children

“…Several studies have reported that circulating CCL2 levels are higher in obese subjects than lean controls and are correlated with BMI percentile [18,[27][28][29]. Samaan et al proposed that circulating CCL2 levels could be a potential biomarker of fitness based on an observed correlation between the BMI percentile and CCL2 [18].…”

“…Samaan et al proposed that circulating CCL2 levels could be a potential biomarker of fitness based on an observed correlation between the BMI percentile and CCL2 [18]. However, Roth et al reported that the changes in BMI-SDS after intervention were not correlated with CCL2 levels [28]. Therefore, further studies are needed to confirm that CCL2 levels may serve as a potential biomarker to monitor the effects of treatment on childhood obesity.…”

Asociación de la resistina con variables de dimensión y composición corporal en eutróficos y obesos

“…En el presente trabajo, los niveles de resistina difieren significativamente entre obesos y eutróficos en el género masculino, presentando los obesos la mayor concentración, lo cual es ratificado por la correlación observada entre resistina e IMC en el grupo total y en los obesos por separado. En sujetos de edad pediátrica, se ha reportado diferencia significativa entre eutróficos y obesos [11][12][13][19][20][21][22] y se ha encontrado correlación positiva entre resistina e IMC 9,19,21 , relación que es considerada por algunos autores como fuerte e independiente de la edad, género y estadio puberal, en obesos 22 . Por el contrario, se ha reportado que no existe diferencia significativa en los niveles de resistina entre eutróficos y obesos 1,3,5,9,23,[24][25][26] o correlación entre ambas variables 1,23,25,27 .…”

“…En sujetos de edad pediátrica se han reportado niveles de resistina significativamente más elevados en obesos [10][11][12] , se han asociado con la masa grasa (MG) o con el porcentaje de masa grasa corporal (%MG) 5,11 sin embargo, otras investigaciones no confirman estas relaciones 1,3,13 . De igual forma, se ha evaluado la correlación de la resistina con el desarrollo puberal, con resultados igualmente controvertidos 1,9,11 .…”