Changed Bcl:Bax ratio in endometrium of patients with unexplained infertility

Vatansever, Hafize Seda; Laçin, Selman; Özbilgin, Mahmut Kemal

doi:10.1016/j.acthis.2005.06.012

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…A recent work described that spontaneous cell death is reduced in the endometrium of unexplained-infertile women further underscoring a functional role for cell death during the IW. 53 In the present work, we observed coated vesicles in the apex of the microvilli-rich and some pinopode cells. They are also found associated with the apical and lateral-basal plasma membranes participating in transcytosis.…”

Section: Discussionmentioning

confidence: 80%

Human Endometrium Ultrastructure During the Implantation Window: A New Perspective of the Epithelium Cell Types

et al. 2011

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The human endometrium is a hormonally regulated tissue that cyclically growths and differentiates in order to become a structure adequate for implantation. Molecular studies have shown some contradicting results and thus a reappraisal of the endometrium ultrastructure is warranted. In our study, endometrium biopsies were taken during the implantation window of 10 healthy women of reproductive age and analyzed using electron microscopy. Our results showed that during implantation window, the endometrial epithelium encompassed 4 cell types: microvilli-rich cells, pinopode cells, vesiculated cells, and ciliated cells. These cells showed signs of active communication with their external environment and neighboring cells, such as endocytosis, transcytosis and exocytosis. We highlighted important differences between surface and glandular epitheliums and characterized apocrine and holocrine secretion. It is likely that the features described reflect distinct functions in endometrium physiology that should be taken into account in the evaluation of the endometrium during the implantation window.

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Section: Discussionmentioning

confidence: 80%

Human Endometrium Ultrastructure During the Implantation Window: A New Perspective of the Epithelium Cell Types

et al. 2011

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“…NO has been shown to induce endometrial epithelial apoptosis (Castro et al 2002; Johnson et al 2004; Li et al 2001), and increased eNOS expression and therefore localized excess NO production at the luminal surface could induce epithelial apoptosis and implantation failure. Vatansever et al also reported increased eNOS immunoreactivity in the endometrium of unexplained infertility patients, although this was associated with lower number of apoptotic cells (Vatansever et al 2005). A second mechanism by which NO might impair implantation is through localized nitrosative stress.…”

Section: Discussionmentioning

confidence: 97%

Altered endometrial expression of endothelial nitric oxide synthase in women with unexplained recurrent miscarriage and infertility

Najafi

Novin

Ghazi

et al. 2012

Reproductive BioMedicine Online

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Background Endothelial nitric oxide synthase (eNOS) has diverse roles in the female reproductive system including a role in blastocyst implantation. Aberrant expression of eNOS could therefore be significant in the pathogenesis of disorders of implantation Materials and Methods eNOS protein and mRNA levels in the endometrium of women with recurrent miscarriages, unexplained infertility, and a control group was determined by compartmental quantitative immunohistochemistry and real time RT-PCR Results eNOS was immunolocalized to all layers of the endometrium and the vascular endothelium. eNOS protein expression was higher in glandular epithelium (P=0.004) and luminal epithelium (P=0.002) but not vascular endothelium and stroma (P=0.14) in women with recurrent miscarriage. Similarly, in women with unexplained infertility eNOS expression was significantly higher (P<0.03) in luminal epithelium but not in any other compartments compared with the control group. The levels of mRNA expression as determined by real time RT-PCR confirmed the protein data demonstrating higher eNOS mRNA expression In the endometrium of women with recurrent miscarriage and unexplained infertility compared with controls Conclusion Increased expression of eNOS in glandular and luminal epithelium of the endometrium in women with recurrent miscarriages and unexplained infertility suggests a detrimental effect of excess nitric oxide in endometrial receptivity and implantation

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“…Similarly, BAX expression also decreases, but it is still present throughout the secretory phase. A decrease in the BCL2 to BAX ratio during the early secretory phase precedes DNA fragmentation and may predispose cells to apoptosis . The overexpression of BCL2 is associated with a reduced expression of the cysteine–aspartic acid protease 8 (CASP‐8), which is involved in the programmed cell death induced by Fas and various apoptotic stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, we found that in these women also, BAX expression was increased so that the above‐described inhibitory effect on apoptosis may be partly counteracted. As apoptosis is an important physiological mechanism in maintaining homeostasis during the menstrual cycle and in early phases of pregnancy, the altered anti‐ to pro‐apoptotic factors ratio in women with CE could affect pregnancy‐mediated tissue remodeling during blastocyst implantation and placental development in the uterus. Moreover, the prevalence of anti‐apoptotic effect may explain an abnormal proliferative effect on the endometrium that we observed in women with CE with the formation of endometrial new growths that we called micropolyps due to their small size (< 1 mm) …”

Section: Discussionmentioning

confidence: 99%

Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apoptotic Proteins in the Endometrium of Infertile Women with Chronic Endometritis

Pietro¹,

Cicinelli

Guglielmino³

et al. 2013

American J Rep Immunol

118

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Changed Bcl:Bax ratio in endometrium of patients with unexplained infertility

Cited by 11 publications

References 37 publications

Human Endometrium Ultrastructure During the Implantation Window: A New Perspective of the Epithelium Cell Types

Human Endometrium Ultrastructure During the Implantation Window: A New Perspective of the Epithelium Cell Types

Altered endometrial expression of endothelial nitric oxide synthase in women with unexplained recurrent miscarriage and infertility

Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apoptotic Proteins in the Endometrium of Infertile Women with Chronic Endometritis

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