Change of proinflammatory cytokines follows certain patterns after induction of endometriosis in a mouse model

Chen, Qionghua; Zhou, Weidong; Su, Zhiying; Huang, Qiansheng; Jiang, Jinna; Chen, Qing‐Xi

doi:10.1016/j.fertnstert.2009.02.013

Cited by 14 publications

(11 citation statements)

References 28 publications

(18 reference statements)

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“…At the other time, the levels were all higher than those of the control group. These patterns were consistent with the profiles of cytokines observed in a previous study [9] . Therefore, we are led to postulate that the first peak reflects the release from the fragments of ectopic endometrial tissues and macrophages recruited.…”

Section: Discussionsupporting

confidence: 92%

“…There were no significant changes in the levels of MMP-2 among the time points after the EM induction while MMP-9 have 2-3 peaks within the 21 days after the EM induction, which was consistent with the results obtained with inflammatory mediators [9] . Our study suggests that the roles and regulation of MMP-2 and MMP-9 differ in the development and progression of EM, which will help us better understand the pathogenesis of EM.…”

Section: Discussionsupporting

confidence: 91%

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Change profiles in matrix metalloproteinase-2 and -9 in induced endometriosis in mice

Chen

Na-xuan

et al. 2010

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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To examine the changes in matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in the development and progression of endometriosis, real time quantitative polymerase chain reaction, enzyme-linked immunoabsorbent assay and gelatin zymography were employed to determine the mRNA and protein levels and activities of MMP-2 and MMP-9 from the first day to the 21(st) day after the induction in mice with induced endometriosis (experimental group) and sham-operated animals (controls). The results showed that the mRNA and protein levels and activities of the MMP-2 and MMP-9 were significantly increased on the first day after the induction and the level of MMP-2 stayed at a level higher than that in the control group. MMP-9 had two or three peaks during the 21 days, taking place at day 1, 4 and 15. It is concluded that the changes in the MMP-2 and MMP-9 might be involved in pathogenesis of endometriosis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Change profiles in matrix metalloproteinase-2 and -9 in induced endometriosis in mice

Chen

Na-xuan

et al. 2010

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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“…Studies in mice have demonstrated that secretion of these cytokines peak within the first few days after i.p. injection of endometrial cells and subsequently decrease to near background levels within a week (42). Thus, after concentrating the peritoneal lavage fluid, we measured IL-6 and MCP-1 levels in short-term experiments before lesions were apparent (3 days after endometrium injection) as well as at the 14-day time point when the endometriotic lesions were quantified.…”

Section: Resultsmentioning

confidence: 99%

Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis

Wieser

Shen

et al. 2012

Fertility and Sterility

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“…Thus, air pollution may engage several proposed pathways in endometriosis disease progression. In human studies and nonhuman primate animal models of endometriosis, there are elevations of proinflammatory cytokines in the peritoneal fluid in diseased subjects (Chen et al 2010; D’Hooghe and Debrock 2002; D’Hooghe et al 2001), as well as increased oxidative stress (Van Langendonckt et al 2002). Additionally, dioxins (through the aryl hydrocarbon receptor) and endocrine disruptors found in diesel exhaust (including through the polycyclic aromatic hyrdrocarbon receptor) (Takeda et al 2004) may influence the local hormonal milieu surrounding the lesion of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Air Pollution Exposures During Adulthood and Risk of Endometriosis in the Nurses’ Health Study II

Mahalingaiah

Hart²,

Laden³

et al. 2014

Environ Health Perspect

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Background: Particulate matter and proximity to large roadways may promote disease mechanisms, including systemic inflammation, hormonal alteration, and vascular proliferation, that may contribute to the development and severity of endometriosis.Objective: Our goal was to determine the association of air pollution exposures during adulthood, including distance to road, particulate matter < 2.5 μm, between 2.5 and 10 μm, and < 10 μm, (PM2.5, PM10–2.5, PM10), and timing of exposure with risk of endometriosis in the Nurses’ Health Study II.Methods: Proximity to major roadways and outdoor levels of PM2.5, PM10–2.5, and PM10 were determined for all residential addresses from 1993 to 2007. Multivariable-adjusted time-varying Cox proportional hazard models were used to estimate the relation between these air pollution exposures and endometriosis risk.Results: Among 84,060 women, 2,486 incident cases of surgically confirmed endometriosis were identified over 710,230 person-years of follow-up. There was no evidence of an association between endometriosis risk and distance to road or exposure to PM2.5, PM10–2.5, or PM10 averaged over follow-up or during the previous 2- or 4-year period.Conclusions: Traffic and air pollution exposures during adulthood were not associated with incident endometriosis in this cohort of women.Citation: Mahalingaiah S, Hart JE, Laden F, Aschengrau A, Missmer SA. 2014. Air pollution exposures during adulthood and risk of endometriosis in the Nurses’ Health Study II. Environ Health Perspect 122:58–64; http://dx.doi.org/10.1289/ehp.1306627

show abstract

Change of proinflammatory cytokines follows certain patterns after induction of endometriosis in a mouse model

Cited by 14 publications

References 28 publications

Change profiles in matrix metalloproteinase-2 and -9 in induced endometriosis in mice

Change profiles in matrix metalloproteinase-2 and -9 in induced endometriosis in mice

Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis

Air Pollution Exposures During Adulthood and Risk of Endometriosis in the Nurses’ Health Study II

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