Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis

Wieser, Friedrich; Wu, Juanjuan; Shen, Zhaoju; Taylor, Robert N.; Sidell, Neil

doi:10.1016/j.fertnstert.2012.03.004

Cited by 44 publications

(49 citation statements)

References 65 publications

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“…Thus, many seemingly discordant features of endometriosis, including decreased cell death, increased growth and migration, inflammation and enhanced invasive properties of intraperitoneally seeded endometrial cells, might be accounted for by the dysregulation of RA signaling. This contention was recently supported in a mouse model of endometriosis where treatment with RA suppressed IL-6 and the establishment, growth and vascularity of peritoneal implants, promoted macrophage differentiation (Wieser et al 2012).…”

Section: Introductionmentioning

confidence: 87%

“…RA treatment reduced cytokine concentrations and the number and size of lesions (Wieser et al 2012). Thus, RA has the potential to suppress the development of endometriotic implants and agents that target the RA-shuttling system may be useful therapeutic targets in the future, bypassing the toxicity and teratogenicity encountered with RA analogs (Fig.…”

Section: Retinoid Pathway and Endometriosismentioning

confidence: 99%

“…In addition, accumulating evidence shows that an aberrant RA metabolism can be a critical factor in the development of endometriosis (Pavone et al 2011, Wieser et al 2012, Pierzchalski et al 2014, Yamagata et al 2015, a common gynecological disease that affects up to 10% of reproductive-age women. This disease is characterized by the ectopic localization of endometrial-like tissues in the pelvic cavity, and its pathogenesis involves uncontrollable cell proliferation and is associated with local invasion and distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…RA plays fundamental roles in the normal maintenance of endometrial physiology (Zheng et al 2000, Sidell et al 2002, Ding et al 2003, Kuroda et al 2013, and aberrant RA metabolism might be a predisposing factor for the development of endometriosis (Pavone et al 2011, Wieser et al 2012, Pierzchalski et al 2014, Yamagata et al 2015. However, a comprehensive and systematic analysis and understanding of RA pathway in endometrial physiology and pathology remain lacking.…”

Section: Introductionmentioning

confidence: 99%

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Physiological and pathological implications of retinoid action in the endometrium

Jiang

Chen

Taylor

et al. 2018

Journal of Endocrinology

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Retinol (vitamin A) and its derivatives, collectively known as retinoids, are required for maintaining vision, immunity, barrier function, reproduction, embryogenesis and cell proliferation and differentiation. Despite the fact that most events in the endometrium are predominantly regulated by steroid hormones (estrogens and progesterone), accumulating evidence shows that retinoid signaling is also involved in the development and maintenance of the endometrium, stromal decidualization and blastocyst implantation. Moreover, aberrant retinoid metabolism seems to be a critical factor in the development of endometriosis, a common gynecological disease, which affects up to 10% of reproductive age women and is characterized by the ectopic localization of endometrial-like tissue in the pelvic cavity. This review summarizes recent advances in research on the mechanisms and molecular actions of retinoids in normal endometrial development and physiological function. The potential roles of abnormal retinoid signaling in endometriosis are also discussed. The objectives are to identify limitations in current knowledge regarding the molecular actions of retinoids in endometrial biology and to stimulate new investigations toward the development potential therapeutics to ameliorate or prevent endometriosis symptoms.

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Section: Introductionmentioning

confidence: 87%

Section: Retinoid Pathway and Endometriosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physiological and pathological implications of retinoid action in the endometrium

Jiang

Chen

Taylor

et al. 2018

Journal of Endocrinology

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“…This effect may be caused, at least in part, by reduced IL-6 and MCP-1 production and enhanced differentiation of peritoneal macrophages. 70 The recruitment, possible proliferation, activation, and differentiation of monocytic lineage cells within the peritoneal cavity or within endometriosis lesions deserve further investigation. 69,[71][72][73] Recommendation.…”

Section: Inflammation and Immunologymentioning

confidence: 99%

Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France

D’Hooghe²,

et al. 2013

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Endometriosis, defined as estrogen-dependent lesions containing endometrial glands and stroma outside the uterus, is a chronic and often painful gynecological condition that affects 6% to 10% of reproductive age women. Endometriosis has estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity. Decreased quality of life is the most important predictor of direct health care and total costs. It has been estimated that there is a mean delay of 6.7 years between onset of symptoms and a surgical diagnosis of endometriosis, and each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working. To encourage and facilitate research into this debilitating disease, a consensus workshop to define future directions for endometriosis research was held as part of the 11th World Congress on Endometriosis in September 2011 in Montpellier, France. The objective of this workshop was to review and update the endometriosis research priorities consensus statement developed following the 10th World Congress on Endometriosis in 2008. 1 A total of 56 recommendations for research have been developed, grouped under 6 subheadings: (1) diagnosis, (2) classification and prognosis, (3) clinical trials, treatment, and outcomes, (4) epidemiology, (5) pathophysiology, and (6) research policy. By producing this consensus international research priorities statement, it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis.

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Whole exome sequencing reveals novel candidate variants for endometriosis utilizing multiple affected members in a single family

Kina,

Topbas Selcuki,

Bahat

et al. 2023

Molec Gen & Gen Med

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BackgroundEndometriosis is an estrogen‐dependent, chronic inflammatory disease that affects 10% of women during the reproductive ages. Despite the estimated 50% heritability for the condition, only 26% was associated with common genetic variants. Thus, necessity of identifying rare variants for the missing heritability is implicated in the literature. Therefore, our study aimed to identify novel rare genetic variants involved in the pathogenesis of endometriosis utilizing a family of multiple affected members.MethodsA family composed of four affected women along with their two unaffected mothers were recruited at a single gynecology and infertility clinic specialized in endometriosis. All patients presented with endometriomas, which was visualized by transvaginal ultrasonography. Two affected individuals had received laparoscopic endometrioma excision and therefore were diagnosed with recurrent disease. One mother had a history of endometrial serous adenocarcinoma (ESC) for which she underwent hysterectomy with bilateral oophorectomy. Three endometriosis cases were whole exome sequenced on Illumina NextSeq 550 platform with an average of 90% coverage. Candidate genes were confirmed by Sanger sequencing and followed‐up with family segregation.ResultsNovel rare variants were identified in TNFRSF1B (NM_001066.3: c.1072G>A, p.(Ala358Thr)) and GEN1 (NM_001130009.3: c.1574C>T, p.(Ser525Leu)) as possible genetic causes of endometriosis. A third novel rare variant was identified in CRABP1 (NM_004378.3:c.54G>C, p.(Glu18Asp)) only on the mother with ESC history and her daughters.ConclusionNovel candidate genetic variants that might contribute to endometriosis were suggested that need replication through independent cohorts or validation by functional studies. The family has also received genetic counseling and that the affected daughters are on clinical follow‐up, accordingly.

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Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis

Cited by 44 publications

References 65 publications

Physiological and pathological implications of retinoid action in the endometrium

Physiological and pathological implications of retinoid action in the endometrium

Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France

Whole exome sequencing reveals novel candidate variants for endometriosis utilizing multiple affected members in a single family

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