Change of Adrenomedullin Concentrations in Plasma and Amniotic Fluid, and Human Placental Adrenomedullin Expression with Advancing Gestation

Kanenishi, Kenji; Kuwabara, Hiroko; Ueno, Masaki; Sato, Chubun; Sakamoto, Haruhiko; Hata, Toshiyuki

doi:10.1053/plac.2000.0604

Cited by 24 publications

(23 citation statements)

References 21 publications

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“…Different research groups have shown elevated levels of AM in plasma of pregnant women at term (from 3-to 5-fold increase), as compared to levels in non-pregnant women or levels in the early puerperium Kanenishi et al, 2001;Kobayashi et al, 2000). Other vasoactive substances, such as endothelin, prostaglandin E2, and prostacyclin, have also been reported to increase in maternal plasma in a similar fashion (Brennecke et al, 1985;Goodman et al, 1982;Mastrogiannis et al, 1991).…”

Section: Clinical Aspects Related To the Levels Of Am In Normal Pregnmentioning

confidence: 92%

“…Within human placenta at term, AM is localized primarily in extravillous trophoblast cells and in the syncytiotrophoblast, but is also present in endothelial cells of villous blood vessels and in maternal decidual cells (Di Iorio et al, 1998c;Kanenishi et al, 2000Kanenishi et al, , 2001Macri et al, 1998;Marinoni et al, 1998). Occasionally, immunocytochemical staining for AM has also been reported in cytotrophoblast cells and in the mesenchyma and inflammatory cells within the villi (Kanenishi et al, 2001;Macri et al, 1998). The fetal membranes, and, more specifically, the epithelium of the amniotic membrane, also show high levels of AM and its mRNA (Kanenishi et al, 2000(Kanenishi et al, , 2001Kobayashi et al, 2000;Macri et al, 1996b;Makino et al, 1999c).…”

Section: Am In Early Developmental Stages Am In Fetoplacental Tissuesmentioning

confidence: 99%

“…Occasionally, immunocytochemical staining for AM has also been reported in cytotrophoblast cells and in the mesenchyma and inflammatory cells within the villi (Kanenishi et al, 2001;Macri et al, 1998). The fetal membranes, and, more specifically, the epithelium of the amniotic membrane, also show high levels of AM and its mRNA (Kanenishi et al, 2000(Kanenishi et al, , 2001Kobayashi et al, 2000;Macri et al, 1996b;Makino et al, 1999c). The pattern and intensity of AM immunoreactivity in the first trimester human placenta and fetal membranes were reported to be similar to that in term pregnancy (Macri et al, 1996a;Kanenishi et al, 2001), suggesting that AM secreted from these sites might play an important role in the maintenance of normal pregnancy throughout gestation.…”

Section: Am In Early Developmental Stages Am In Fetoplacental Tissuesmentioning

confidence: 99%

“…membranes (168.7 Ϯ 2.3 pg/mg wet tissue) is comparable to the AM concentration in adrenal medulla (157.3 Ϯ 74.4 pg/mg wet tissue) (Marinoni et al, 1998), thus being much higher than that found in other human tissues examined (Kim, 1999;Kitamura et al, 1998). Since AM has potent vasodilator properties (Kitamura and Eto, 1997;Letizia et al, 1999), the expression of AM in placenta and fetal membranes, together with high AM levels in pregnant uterus (Upton et al, 1997), maternal plasma, and amniotic fluid (Di Iorio et al, 1997bKanenishi et al, 2001), makes it likely that during normal pregnancy AM may contribute to the regulation of the placental vascular tone. Very interestingly, using isolated perfused placental cotyledons, AM was shown to cause vasodilatation of fetoplacental vasculature previously constricted with a thromboxane sympathomimetic (Hoeldtke et al, 2000), thus providing physiological support to the possible vasodilatory effect of AM in the regulation of fetoplacental vascular tone.…”

Section: Am In Early Developmental Stages Am In Fetoplacental Tissuesmentioning

confidence: 99%

“…Other vasoactive substances, such as endothelin, prostaglandin E2, and prostacyclin, have also been reported to increase in maternal plasma in a similar fashion (Brennecke et al, 1985;Goodman et al, 1982;Mastrogiannis et al, 1991). However, when comparing AM concentrations in plasma throughout pregnancy, some investigators have found no significant changes between different periods , whereas others have reported increasing concentrations with advancing gestation (Kanenishi et al, 2001), or significant increases only in the third trimester (Kobayashi et al, 2000).…”

Section: Clinical Aspects Related To the Levels Of Am In Normal Pregnmentioning

confidence: 99%

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Adrenomedullin in mammalian embryogenesis

Garayoa

Bodegas

Cuttitta

et al. 2002

Microscopy Res & Technique

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Here are summarized data supporting that adrenomedullin (AM) is a multifunctional factor involved in the complex regulatory mechanisms of mammalian development. During rodent embryogenesis, AM is first expressed in the heart, followed by a broader but also defined spatio-temporal pattern of expression in vascular, neural, and skeletal-forming tissues as well as in the main embryonic internal organs. AM pattern of expression is suggestive of its involvement in the control of embryonic invasion, proliferation, and differentiation processes, probably through autocrine or paracrine modes of action. AM levels in fetoplacental tissues, uterus, maternal and umbilical plasma are highly increased during normal gestation. These findings in addition to other physiological and gene targeting studies support the importance of AM as a vasorelaxant factor implicated in the regulation of maternal vascular adaptation to pregnancy, as well as of fetal and fetoplacental circulations. AM is also present in amniotic fluid and milk, which is suggestive of additional functions in the maturation and immunological protection of the fetus. Altered expression of AM has been found in some gestational pathologies, although it is not yet clear whether this corresponds to causative or compensatory mechanisms. Future studies in regard to the distribution and expression levels of the molecules known to function as AM receptors, together with data on the action of complement factor H (an AM binding protein), may help to better define the roles of AM during embryonic development.

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Section: Clinical Aspects Related To the Levels Of Am In Normal Pregnmentioning

confidence: 92%

Section: Am In Early Developmental Stages Am In Fetoplacental Tissuesmentioning

confidence: 99%

Section: Am In Early Developmental Stages Am In Fetoplacental Tissuesmentioning

confidence: 99%

Section: Am In Early Developmental Stages Am In Fetoplacental Tissuesmentioning

confidence: 99%

Section: Clinical Aspects Related To the Levels Of Am In Normal Pregnmentioning

confidence: 99%

See 3 more Smart Citations

Adrenomedullin in mammalian embryogenesis

Garayoa

Bodegas

Cuttitta

et al. 2002

Microscopy Res & Technique

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Regulation of adrenomedullin expression and release

Minamino

Kikumoto

Isumi

2002

Microscopy Res & Technique

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Adrenomedullin (AM) was originally identified in the extracts of human pheochromocytoma tissue, but this peptide is now known to be synthesized and secreted from many kinds of cells in the body, including vascular smooth muscle cells, endothelial cells, fibroblasts, cardiac myocytes, epithelial cells, and cancer cells. In this review, we summarize AM-secreting and AM gene-expressing cells in addition to the regulation of secretion and gene expression of AM. Although the data are still limited to deduce the general features of AM gene expression, synthesis, and secretion, AM is assumed to be classified into the new class of biologically active peptides, which is mainly expressed and secreted from non-endocrine type cells by the stimulation with inflammation-related substances. It is also interesting that serious physiological conditions such as inflammation or hypoxia potently stimulate AM expression and release, suggesting its unique physiological function distinct from other known biologically active peptides.

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Current Awareness

2001

Prenatal Diagnosis

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of prenatal diagnosis. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General Interest; 3 Normal Fetal Development; 4 Gametogenesis and Pre‐implantation Diagnosis; 5 First Trimester Diagnosis; 6 Second Trimester Diagnosis; 7 Fetal Diagnosis by Ultrasound and Other Imaging; 8 Maternal Screening; 9 Screening for Carriers of Genetic Abnormality; 10 Technological Developments; 11 Confined Placental Mosaicism and Uniparental Disomy; 12 Molecular Cytogenetics; 13 Fetal Cells in Maternal Circulation; 14 Fetal Therapy; 15 Psychosocial Aspects; 16 Epidemiology and Environmental Factors; 17 Developmental Pathology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Change of Adrenomedullin Concentrations in Plasma and Amniotic Fluid, and Human Placental Adrenomedullin Expression with Advancing Gestation

Cited by 24 publications

References 21 publications

Adrenomedullin in mammalian embryogenesis

Adrenomedullin in mammalian embryogenesis

Regulation of adrenomedullin expression and release

Current Awareness

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