2002
DOI: 10.1002/jemt.10050
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Adrenomedullin in mammalian embryogenesis

Abstract: Here are summarized data supporting that adrenomedullin (AM) is a multifunctional factor involved in the complex regulatory mechanisms of mammalian development. During rodent embryogenesis, AM is first expressed in the heart, followed by a broader but also defined spatio-temporal pattern of expression in vascular, neural, and skeletal-forming tissues as well as in the main embryonic internal organs. AM pattern of expression is suggestive of its involvement in the control of embryonic invasion, proliferation, a… Show more

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Cited by 26 publications
(16 citation statements)
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“…In addition, ADM and ADM-Rs were shown to be ubiquitously expressed during embryogenesis. Especially maternal decidual cells and embryonic cytotrophoblast cells show high levels of ADM and ADM-R expression and it has been reasoned that ADM might facilitate the invasion of cells (30)(31)(32). With respect to carcinogenesis, ADM may be involved in a similar process during tumor cell invasion (33).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, ADM and ADM-Rs were shown to be ubiquitously expressed during embryogenesis. Especially maternal decidual cells and embryonic cytotrophoblast cells show high levels of ADM and ADM-R expression and it has been reasoned that ADM might facilitate the invasion of cells (30)(31)(32). With respect to carcinogenesis, ADM may be involved in a similar process during tumor cell invasion (33).…”
Section: Discussionmentioning
confidence: 99%
“…Ten micrograms of nuclear extracts were preincubated on ice for 20 minutes in a binding-buffer [12 mmol/L HEPES (pH 7.9), 4 mmol/L Tris-HCl (pH 7.9), 60 mmol/L KCl, 1 mmol/L EDTA, 1 mmol/L DTT] with 100 ng thymus DNA. After the addition of [g- 32 P]ATP, the samples were incubated for 30 minutes at room temperature. For supershift assays, the samples were additionally incubated with an anti-HIF-1a monoclonal antibody (Transduction Laboratories) for 16 hours at 4jC.…”
Section: Methodsmentioning
confidence: 99%
“…The gene coding for AM is widely expressed throughout the body, most highly in endothelial cells and vascular smooth muscle cells (2,3). Consequently, highly vascularized tissues, such as the placenta, lung, heart, and kidney cause elevated plasma AM levels when their secretion of AM peptide is stimulated by conditions such as pregnancy, sepsis, and cardiovascular disease or by inflammatory cytokines or hypoxia.…”
mentioning
confidence: 99%
“…Currently, ADM has been concerned in a multiplicity of reproductive functions, specifically during pregnancy. In the human, plasma ADM levels were raised during pregnancy and reduced at term [1][2][3][4]. This augmentation in ADM levels happened immediately after implantation, and subsequently, decrease of ADM took place in both plasma [5,6] and amniotic fluid [7] later in gestation.…”
Section: Introductionmentioning
confidence: 91%
“…The blastocyst signals that induce the apoptotic cascade, as well as the genes that regulate this local event, are still unknown. Recent reports suggest that AM is a regulator of cell growth and differentiation [4] and that it plays a potent protective role against apoptosis and in maintaining cellular integrity. Hence, normal ADM function is required to prevent apoptosis and sustain normal implantation, placental development, and fetal growth.…”
Section: Introductionmentioning
confidence: 99%