Change in the Gut Microbiome and Immunity by Lacticaseibacillusrhamnosus Probio-M9

Zhang, Meng; Zheng, Yan; Sun, Zheng; Cao, Chuan; Zhao, Wei; Liu, Yangshuo; Zhang, Wenyi; Zhang, Heping

doi:10.1128/spectrum.03609-22

Cited by 7 publications

(8 citation statements)

References 88 publications

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“…lactis Probio-M8 and Lacticaseibacillus rhamnosus Probio-M9, have been isolated from breast milk. 15,16 This aligns with the contemporary understanding of breast milk as a biologically active fluid that contributes to infant development. 2,8,17 The origin of these microbes is diverse and complex, involving interactions with the infant's oral cavity, maternal dermis, maternal digestive tract, and other pathways.…”

Section: Introductionsupporting

confidence: 63%

“…Previously, the prevailing scientific consensus was that breast milk was a sterile fluid. , However, modern scientific methodologies have revealed the presence of a diverse microbiota in breast milk. , For example, interesting beneficial microorganisms, such as Bifidobacterium animalis ssp. lactis Probio-M8 and Lacticaseibacillus rhamnosus Probio-M9, have been isolated from breast milk. , This aligns with the contemporary understanding of breast milk as a biologically active fluid that contributes to infant development. ,, The origin of these microbes is diverse and complex, involving interactions with the infant’s oral cavity, maternal dermis, maternal digestive tract, and other pathways. ,, While the microbial consortium within breast milk remains relatively consistent, it can be still modulated by various external determinants, such as maternal dietary habits, lifestyle patterns, and overall health. ,, These microbes play a crucial role in fostering a beneficial gut environment for the infant, thereby contributing to long-term health. , Additionally, the metabolites released by these microbes make breast milk an invaluable source of nutrients . For instance, short-chain fatty acids (SCFAs) like acetate, butyrate, and propionate have specific physiological roles in supporting gut health, modulating local immune responses, and energizing cells. − Certain microbial metabolites, such as bioactive peptides, prebiotics, and nucleotides, are essential for the infant’s nutritional uptake, immune regulation, and anti-inflammatory activities. ,, …”

Section: Introductionmentioning

confidence: 60%

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Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health

Zhang,

Qiao,

Yang

et al. 2024

J. Agric. Food Chem.

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This review explores the role of microorganisms and metabolites in human breast milk and their impact on neonatal health. Breast milk serves as both a primary source of nutrition for newborns and contributes to the development and maturation of the digestive, immunological, and neurological systems. It has the potential to reduce the risks of infections, allergies, and asthma. As our understanding of the properties of human milk advances, there is growing interest in incorporating its benefits into personalized infant nutrition strategies, particularly in situations in which breastfeeding is not an option. Future infant formula products are expected to emulate the composition and advantages of human milk, aligning with an evolving understanding of infant nutrition. The long-term health implications of human milk are still under investigation.

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Section: Introductionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 60%

Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health

Zhang,

Qiao,

Yang

et al. 2024

J. Agric. Food Chem.

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“…Increased abundances of Agathobacter and Holdemanella were observed in the probiotic group and Agathobacter is a butyrateproducing organism found in healthy individuals and has been observed to be increased in the presence of probiotic bacteria. 60,61 Enriched abundances of Holdemanella have been associated with decreased IBS-SSS and fatigue in people with IBS. 62 Prevotella, Bacteroides, Anaerostipes, and Ruminococcus were enriched in the placebo group.…”

Section: Discussionmentioning

confidence: 99%

A double‐blind, randomized, placebo‐controlled study assessing the impact of probiotic supplementation on the symptoms of irritable bowel syndrome in females

Mullish,

Michael,

Dabcheva

et al. 2024

Neurogastroenterology Motil

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BackgroundA previous exploratory study demonstrated the ability of the Lab4 probiotic to alleviate the symptoms of IBS, and post hoc data analysis indicated greatest improvements in the female subgroup. The aim of this study is to confirm the impact of this multistrain probiotic on IBS symptom severity in females.MethodsAn 8‐week, single‐center, randomized, double‐blinded, placebo‐controlled, superiority study in 70 females with Rome IV‐diagnosed irritable bowel syndrome (IBS) receiving the Lab4 probiotic (25 billion colony‐forming units) daily or a matched placebo. Changes from baseline in the IBS‐symptom severity score (IBS‐SSS), daily bowel habits, anxiety, depression, IBS‐related control, and avoidance behavior, executive function, and the fecal microbiota composition were assessed. The study was prospectively registered: ISRCTN 14866272 (registration date 20/07/22).Key ResultsAt the end of the study, there were significant between‐group reductions in IBS‐SSS (−85.0, p < 0.0001), anxiety and depression scores (−1.9, p = 0.0002 and −2.4, p < 0.0001, respectively), and the IBS‐related control and avoidance behavior score (−7.5, p = 0.0002), all favoring the probiotic group. A higher proportion of the participants in the probiotic group had normal stool form (p = 0.0106) and/or fewer defecations with loose stool form (p = 0.0311). There was little impact on the overall diversity of the fecal microbiota but there were significant differences in Roseburia, Holdemanella, Blautia, Agathobacter, Ruminococcus, Prevotella, Bacteroides, and Anaerostipes between the probiotic and placebo groups at the end of the study.Conclusions & InferencesDaily supplementation with this probiotic may represent an option to be considered in the management of IBS.

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“…Interestingly, acetylcarnitine has been identified as a beneficial metabolite in lowering blood lipids. A study on probiotics revealed that acetylcarnitine levels increased significantly following probiotic supplementation, resulting in decreased serum TC and TG levels (Huan Wang et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

Chen,

Wang,

Guo

et al. 2024

Food Science & Nutrition

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The primary objective of this investigation was to explore the beneficial impacts of Enteromorpha prolifera polysaccharide (EP) on dysglycemia in Zucker diabetic fatty (ZDF) rats, while also shedding light on its potential mechanism using 1H‐NMR‐based metabolomics. The results demonstrated a noteworthy reduction in fasting blood glucose (FBG, 46.3%), fasting insulin (50.17%), glycosylated hemoglobin A1c (HbA1c, 44.1%), and homeostatic model assessment of insulin resistance (HOMA‐IR, 59.75%) following EP administration, while the insulin sensitivity index (ISI, 19.6%) and homeostatic model assessment of β‐cell function (HOMA‐β, 2.5‐fold) were significantly increased. These findings indicate that EP enhances β‐cell function, increases insulin sensitivity, and improves insulin resistance caused by diabetes. Moreover, EP significantly reduced serum lipid levels, suggesting improvement of dyslipidemia. Through the analysis of serum metabolomics, 17 metabolites were found to be altered in diabetic rats, 14 of which were upregulated and 3 of which were downregulated. Notably, the administration of EP successfully reversed the abnormal levels of 9 out of the 17 metabolites. Pathway analysis further revealed that EP treatment partially restored metabolic dysfunction, with notable effects observed in valine, leucine, and isoleucine metabolism; aminoacyl‐transfer RNA (tRNA) biosynthesis; and ketone body metabolism. These findings collectively indicate the potential therapeutic efficacy of EP in preventing glycemic abnormalities and improving insulin resistance. Thus, EP holds promise as a valuable treatment option for individuals with diabetes.

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Change in the Gut Microbiome and Immunity by Lacticaseibacillusrhamnosus Probio-M9

Cited by 7 publications

References 88 publications

Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health

Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health

A double‐blind, randomized, placebo‐controlled study assessing the impact of probiotic supplementation on the symptoms of irritable bowel syndrome in females

¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

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Change in the Gut Microbiome and Immunity by Lacticaseibacillusrhamnosus Probio-M9

Cited by 7 publications

References 88 publications

Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health

Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health

A double‐blind, randomized, placebo‐controlled study assessing the impact of probiotic supplementation on the symptoms of irritable bowel syndrome in females

1H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

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¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats