Change in moles linked to use of unlicensed "sun tan jab"

The dysplastic nevus: From historical perspective to management in the modern era

“…Cardones and Grichnik 79 described a 40-year-old male who developed multiple new DN following self administration of α-melanocyte-stimulating hormone. Similarly, Langan et al 80 reported two patients presenting with new and rapidly changing DN following subcutaneous injection of melanotan I and II.…”

Ultraviolet Light as a Modulator of Melanoma Development

“…To quote Lin and Fisher (2007), "could it be that keratinocytes are the primary UV responding population, and melanoma formation is largely a consequence of reactive secondary stimulation?" In fact the injection of highly active MSH analogues may be naevis promoting (Cardones et al, 2009;Langan et al, 2009). However the notion of UVR-induced melanocyte proliferation being melanomagenic is at odds with findings that stimulation of melanocytes with factor such as a-MSH (e.g.…”

SMART: An Internet study of users experiences of synthetic tanning

“…Descriptions of acute and chronic effects of melanotan are consistent with clinical literature (Cardones et al, 2009;Cousen et al, 2009;Dorr et al, 1996;Ellis et al, 2009;FerrandizPulido et al, 2011;Langan et al, 2009;Paurobally et al, 2011;Rhodes & Langan, 2011;Thestrup-Pedersen & Sondergaardm, 2010;Thestrup-Pedersen, 2011;von Bartenwerffer, Siebenhaar, & Hunzelmann, 2011;Wessells et al, 1998Wessells et al, , 2000. Negative outcomes were managed proactively with monitoring of dosage, administration of pharmaceuticals and restricted photo therapy.…”

“…Dysplastic changes in existing nevi, eruptive atypical melanocytic nevi or appearance of new lesions and freckles following melanotan use are common (Burian, 2013;Cardones, Rand, & Richnik, 2009;Cousen et al, 2009;Ferrandiz-Pulido, Fernandez-Figueras, Quer, & Ferrandiz, 2011;Hueso-Gabriel et al, 2012;Javed et al, 2013;Langan, Ramlogan, Jamieson, & Rhodes, 2009;Langan et al, 2010;Ong & Bowling, 2012;Paurobally et al, 2011;Reid, Fitzgerald, Fabre, & Kirby, 2013;Sivyer, 2012;Thestrup-Pedersen & Sondergaard, 2010). Cases of malignant melanomas have also been reported (Ellis, Kirkham, & Seukeran, 2009;Paurobally et al, 2011Paurobally et al, , 2013.…”