Change in meal size, number and duration after neural isolation of liver and with TPN

Ratto, Carlo; Gleason, John R.; Yang, Zhong-Jin; Bellantone, Rocco Domenico Alfonso; Crucitti, F; Meguid, Michael M.

doi:10.1016/0031-9384(91)90553-z

Cited by 18 publications

(1 citation statement)

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“…Moreover, hepatic receptors appear to be key elements contributing to the sensations of hunger and satiety. Both the frequency and size of meals are altered in rats in which neural signaling between the liver and central nervous system is interrupted by total hepatic denervation or hepatic vagotomy (Ratto et al, 1991;Yang et al, 1992). Thus, the portal signal is not an isolated mechanism for regulating hepatic carbohydrate but instead appears to be part of an elaborate system for control of whole body carbohydrate metabolism.…”

Section: Effects Of the Portal Signal On Nonhepatic Tissuesmentioning

confidence: 99%

Regulation of net hepatic glucose uptake: interaction of neural and pancreatic mechanisms

Moore¹,

Cherrington²

1996

Reprod. Nutr. Dev.

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Summary ― Insulin and glucagon levels, the mass of glucose presented to the liver and the portal signal are important regulators of the liver's response to glucose delivery. The portal signal not only serves to direct glucose into the liver but also appears to stimulate its deposition in glycogen. Moreover, the portal signal impacts on tissues other than the liver: intraportal glucose delivery is associated with changes in glucose uptake by nonhepatic tissues and neurally-mediated enhancement of pancreatic insulin secretion. Our current understanding of the neural control of hepatic glucose metabolism includes a tonic block to the entry of glucose into the liver, probably mediated both by sympathetic neural activity and by a low insulin:glucagon ratio. An increase in the portal vein glucose level is detected by sensors in the portal region, which cause a decrease in the firing rate in the afferent fibers in the hepatic branch of the vagus nerve. The change in the afferent firing rate is processed in the hypothalamus and instigates a change in the efferent firing rate in the hepatic and pancreatic branches of the vagus (with corresponding increases in insulin secretion and net hepatic glucose uptake). The

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Section: Effects Of the Portal Signal On Nonhepatic Tissuesmentioning

confidence: 99%