Olfactory bulbectomy in rats modulates feeding pattern but not total food intake

Meguid, Michael M.; Gleason, John R.; Yang, Zhong-Jin

doi:10.1016/0031-9384(93)90238-b

Cited by 36 publications

(18 citation statements)

References 30 publications

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“…Earlier studies by Meguid et al . indicated that while there were qualitative changes in feeding patterns at day 14 post surgery, the quantity of food consumed was not affected following surgery 35. Furthermore, additional studies did not show any chronic (40 days) changes in either qualitative or quantitative feeding behavior 36.…”

Section: Discussionmentioning

confidence: 93%

Altered colonic function and microbiota profile in a mouse model of chronic depression

Park

Collins

Blennerhassett

et al. 2013

Neurogastroenterology Motil

256

179

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Background Depression often coexists with the irritable bowel syndrome (IBS) which is characterized by alterations in gut function. There is emerging evidence that the microbial composition (microbiota) of the gut is altered in IBS, but the basis for this is poorly understood. The aim of this study was to determine whether the induction of chronic depression results in changes in the colonic function and in its microbial community, and to explore underlying mechanisms.Methods Bilateral olfactory bulbectomy (OBx) was used to induce depression-like behavior in mice. Colonic function was assessed by measuring muscle contractility, pellet excretion, c-fos activity, and serotonin levels. Microbiota profiles were obtained using denaturing gradient gel electrophoresis (DGGE). The hypothalamic-pituitary axis (HPA) was assessed by the hypothalamic expression of corticotropin-releasing hormone (CRH). In separate studies, mice without OBx received CRH via intracerebroventricular (ICV) infusion for 4 weeks prior to assessing colonic function and microbiota profiles.Key Results Olfactory bulbectomy mice demonstrated chronic depression- and anxiety-like behaviors associated with elevated central CRH expression and increases in c-Fos activity, serotonin levels, and motility in the colon. These changes were accompanied by an altered intestinal microbial profile. Central CRH administration produced similar changes in behavior and motility and altered the microbiota profile in the colon.Conclusions & Inferences The induction of chronic depression alters motor activity and the microbial profile in the colon likely via activation of the HPA. These findings provide a basis for linking the behavioral and gastrointestinal manifestations of IBS.

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Section: Discussionmentioning

confidence: 93%

Altered colonic function and microbiota profile in a mouse model of chronic depression

Park

Collins

Blennerhassett

et al. 2013

Neurogastroenterology Motil

256

179

View full text Add to dashboard Cite

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“…In the rat, olfactory bulbectomy (OBX) results in a characteristic behavioral phenotype, including disrupted circadian patterns in sleep (Sakurada et al 1976;Araki et al 1980), feeding (La Rue and LeMagnen 1972;Meguid et al 1993) increased irritability (Jesberger and Richardson 1986), and hyperactive responding in a novel, stressful environment (Marks et al 1971;Van Riezen and Leonard 1990;Giardina and Radek 1991). Many of these effects are not observed in animals rendered anosmic by destroying the olfactory receptor cells through irrigation of the nasal mucosa with zinc sulfate (ZnSO 4 ) (Alberts and Friedman 1972;Edwards 1974;Sieck and Baumbach 1974).…”

Section: Introductionmentioning

confidence: 95%

Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

2000

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“…The OBX rats were unable to locate buried sweetened milk, although they had quickly consumed milk in their home cages. In previous studies, the changes in feeding pattern observed in the first few weeks after OBX (Larue, 1975a; Larue and Le Magnen, 1971, 1972; Meguid et al, 1993) were not found after transection of the vomeronasal nerve (Larue and Le Magnen, 1973), but were observed after zinc sulfate was applied to the olfactory mucosa (Larue, 1975b), suggesting that the changes were the result of ablation-induced anosmia and not to loss of other functions of the olfactory bulbs. A small pilot study conducted by King and colleagues suggests that rats made anosmic with zinc sulfate also do not respond to 2-DG.…”

Section: Discussionmentioning

confidence: 92%

“…Removal of the olfactory bulbs (OBX) alters the typical rodent feeding pattern of distinct meals followed by long intermeal intervals to that of frequent small meals (Meguid et al, 1993) or a persistent nibbling pattern (Larue, 1975a; Larue and Le Magnen, 1971, 1972) in the first several weeks following surgery. Rats with OBX also do not respond normally to changes in their diet.…”

Section: Introductionmentioning

confidence: 99%

Olfactory bulbectomy impairs the feeding response to 2-deoxy-d-glucose in rats

et al. 2011

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An early study reported that, unlike sham-operated rats, rats made anosmic by olfactory bulbectomy (OBX) failed to compensate for the dilution of their diet with nonnutritive bulk by increasing their food intake. In the present study, the effects of a glucoprivic challenge, intraperitoneal-administered 350 mg/kg 2-deoxy-D-glucose (2-DG), on food intake were measured in OBX and sham-operated female rats. Sham-operated rats significantly increased their food intake, but in two separate experiments OBX rats displayed no increase in food intake during the first 2 h following administration. Blood glucose levels were nearly identical in both groups. Body weights and daily food intakes of OBX rats did not differ from the sham-operated controls throughout the studies. Bulbectomized rats also displayed a normal drinking response after an intraperitoneal injection of 1 M hypertonic saline. Hypothalamic nuclei and the neural pathways mediating taste have been implicated in the feeding response to 2-DG. The present results suggest that olfactory input and olfactory neural pathways also mediate, at least in part, the feeding response to a glucoprivic challenge induced by intraperitoneal injection of 2-DG.

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Olfactory bulbectomy in rats modulates feeding pattern but not total food intake

Cited by 36 publications

References 30 publications

Altered colonic function and microbiota profile in a mouse model of chronic depression

Altered colonic function and microbiota profile in a mouse model of chronic depression

Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat

Olfactory bulbectomy impairs the feeding response to 2-deoxy-d-glucose in rats

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