Change in kidney damage biomarkers after 13weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae

Toxicologic assessment of Paecilomyces tenuipes in rats: Renal toxicity and mutagenic potential

“…Therefore, our histopathological finding on kidney cell karyomegaly induced by the P. tenuipes may provide the evidence on the potential role of the P. tenuipes in the development of tumor although further study on carcinogenicity is needed. Noteworthy, kidney changes caused by the P. tenuipes extract were more severe in male animals than females in the histopathological lesions of renal tubule cells in agreement with recent result on the P. sinclairii (Jeong et al, 2013). Female rodents have been reported to resist ischemic acute renal failure or glomerulosclerosis through the estrogen activity (Muller et al, 2002;Antus et al, 2003;Wei et al, 2005), supporting our results on the difference of susceptibility to kidney injury between male and female rats.…”

“…tenuipes, an entomogenous fungus on the larvae of lepidoptera, is widely used in traditional nutritious medicine in the Orient (Lee et al, 2006). In spite of lots of reports on the beneficial activities of Paecilomyces species, there have also been several studies on the toxicities of Paecilomyces species, especially P. sinclairii, including acute oral toxicity studies in dogs, subchronic oral toxicity study in rats and a series of genotoxicity studies (Ahn et al, 2003(Ahn et al, , 2004aJeong et al, 2012Jeong et al, , 2013. Among Paecilomyces species, the P. tenuipes-contained processed goods have also been developed in many countries, particularly South Korea (Nam et al, 2011).…”